Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis

Neuropathology and Applied Neurobiology

Volumn 23, Issue 3, 1997, Pages 242-253

  Krajewski, S ^a   James, H J ^b   Ross, J ^b   Blumberg, B M ^b   Epstein, L G ^b   Gendelman, H E ^d   Gummuluru, S ^b   Dewhurst, S ^b   Sharer, L R ^c   Reed, J C ^a   Gelbard, H A ^b  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Astrocyte; Bax; Bcl 2; Bcl x; CNS; Human immunodeficiency virus type 1 (HIV 1); Macrophage; Microglia; Programmed cell death

Indexed keywords

DNA FRAGMENT; GENE PRODUCT; PROTEIN BCL 2;

ADOLESCENT; APOPTOSIS; ARTICLE; ASTROCYTE; BASAL GANGLION; BRAIN CORTEX; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOBLOTTING; INFANT; MACROPHAGE; MICROGLIA; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; VIRUS ENCEPHALITIS;

EID: 8544252431     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.1997.tb01208.x     Document Type: Article

References (51)

1. Adle-Biassette H, Levy Y, Colombel M, Poron F, Natchev S, Keohane C, Gray F. Neuronal apoptosis in HIV infection in adults. Neuropathol Appl Neurobiol 1995; 21: 218-27
2. Badley AD, McElhinny JA, Leibson PJ et al. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J Virol 1996; 70: 199-206
3. Benos DJ, Hahn BH, Bubien JK et al. Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alter ion transport in astrocytes: implications for AIDS dementia complex. Proc Natl Acad Sci USA 1994; 91: 494-8
4. Boise LH, Gonzalez-Garcia M, Postema CE et al. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74: 597-608
5. Center for Disease Control. Center for Disease Control classification system for human immunodeficiency virus (HIV) infection in children under 13 years of age. MMWR 1987; 103: 665-70
6. Dickson DW. Apoptosis in the brain. Am J Pathol 1995; 146: 1040-3
7. Dollard SC, James HJ, Sharer LR, Epstein L G, Gelbard HA, Dewhurst S. Activation of nuclear factor κB in brains from children with HIV-1 encephalitis. Neuropathol Appl Neurobiol 1995; 21: 518-28
8. Everall IP, Luthert PJ, Lantos PL. Neuronal loss in the frontal cortex in HIV infection. Lancet 1991; 337: 1119-21
9. Fine SM, Angel RA, Perry SW et al. Tumor necrosis factor a inhibits glutamate uptake by primary human astrocytes. J Biol Chem 1996; 271: 15303-6
10. Finkel TH, Tudor-Williams G, Banda NK et al. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nature Med 1995; 1: 129-35
11. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501
12. Gehrmann J, Banati RB. Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury. J Neuropathol Exp Neurol 1995; 54: 680-8
13. Gelbard HA, Dzenko K, DiLoreto D, del Cerro C, del Cerro M, Epstein LG. Neurotoxic effects of tumor necrosis factor in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis. Dev Neurosci 1994; 15: 417-22
14. Gelbard HA, James H, Sharer L et al. Apoptotic neurons in brains of paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol Appl Neurobiol 1995; 21: 208-17
15. Gelbard HA, Nottet HSLM, Swindells S et al. Platelet activating factor: a candidate HIV-1-induced neurotoxin. J Virol 1994; 68: 4628-35
16. Gendelman HE, Orenstein J, Martin MA et al. Efficient isolation and propagation of human immunodeficiency virus on CSF-1 stimulated macrophages. J Exp Med 1988; 167: 1428-41
17. Genis P, Jett M, Bernton EW et al. Cytokines and arachidonic acid metabolites produced during HIV-infected macrophage-astroglial interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 1992; 176: 1705-18
18. Glass JD, Fedor H, Wesselingh SL, McArthur JC. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 1995; 38: 755-62
19. Greywoode GIN, McCarthy SP, McGee J. Labelling of cells of the mononuclear phagocyte system in routinely processed archival biopsy specimens with monoclonal antibody EBM/ 11. J Clin Pathol 1990; 43: 992-6
20. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 1995; 270: 1189-93
21. Guan RJ, Moss SF, Arber N, Krajewski S, Reed JC, Holt PR. 30 Kda phosphorylated form of Bcl-2 protein in human colon. Oncogene (in press)
22. Haldar S, Jena N, Croce CM. Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci USA 1995; 92: 4507-11
23. Kalter DC, Nakamura M, Turpin JA et al. Enhanced HIV replication in MCSF-treated monocytes. J Immunol 1991; 146: 298-306
24. Ketzler S, Weis S, Haug H, Budka H. Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropath 1990; 80: 92-4
25. Kobayashi T et al. Expression of Fas/APO-1 as an early and Bax as a late event in irradiation-induced apoptosis of wild-type p53-containing leukemia cells. Blood 1996; (in press)
26. Krajewska M, Krajewski S, Epstein JI et al. Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in prostate cancers., Am J Pathol (in press)
27. Krajewska M, Krajewski S, Epstein JI et al. Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in prostate cancers. Am J Pathol (in press)
28. Krajewski S, Bodrug S, Gascoyne R, Berean K, Krajewska M, Reed JC. Immunohistochemical analysis of mcl-1 and bcl-2 proteins in normal and neoplastic lymph nodes. Am J Pathol 1994; 145: 515-25
29. Krejewski S, Krajewska M, Shabaik A, Miyashita T, Wang HG, Reed JC. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 1994; 145: 1323-36
30. Krajewski S, Blomqvist C, Franssila K et al. Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 1995; 55: 4471-8
31. Krajewski S, Chatten C, Hanada M, Reed JC. Immunohistochemical analysis of the bcl-2 oncoprotein in human neuroblastomas. Lab Invest 1995; 71: 42
32. Krajewski S, Krajewska M, Shabaik A et al. Immunohistochemical analysis of in vivo patterns of bcl-x expression. Cancer Res 1954; 54: 5501-7
33. Mah SP, Zhong LT, Liu Y, Roghani A, Edwards RH, Bredesen DE. The proto-oncogene bcl-2 inhibits apoptosis in PC12 cells. J Neurochem 1993; 60: 1183-6
34. Merry DE, Veis DJ, Hickey WF, Korsmeyer SJ. Bcl-2 protein expression is widespread in the developing central nervous system and retained in the adult PNS. Development 1994; 120: 301-11
35. Michaels J, Sharer LR, Epstein LG. Human immunodeficiency virus type 1 (HIV-1) infection of the nervous system: a review. Immunodef Rev 1988; 1: 71-104
36. Munn DH, Beall AC, Song D, Wrenn RW, Throckmorton DC. Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon-gamma. J Exp Med 1995; 181: 127-36
37. Muro-Cacho CA, Pantaleo G, Fauci AS. Analysis of apoptosis in lymph nodes of HIV-infected persons. J Immunol 1995; 154: 5555-66
38. Myers G, Berzofsky JA, Korber B, Smith RF (eds). Human Retroviruses and AIDS. New Mexico: Los Alamos National Laboratory, 1991: IA95
39. Nottet SLM, Jett M, Flanagan CR et al. A regulatory role for astrocytes in HIV-1 encephalitis. J Immunol 1995; 154: 3567-81
40. Oltvai ZN, Millman CL, Korsmeyer SJ, bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 1993; 74: 609-19
41. Petito CK, Roberts B. Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 1995; 146: 1121-30
42. Reid DM, Perry VH, Andersson PB, Gordon S. Mitosis and apoptosis of microglia in vivo induced by an anti-CR3 antibody which crosses the blood-brain barrier. Neurosci 1993; 56: 529-33
43. Schwaiger M, Herzog V, Neupert W. Characterization of translocation contact sites involved in the import of mitochondrial proteins. J Cell Biol 1987; 105: 235-46
44. Shabaik A, Krajewski S, Burgan A, Krajewska M, Reed JC. bcl-2 proto-oncogene expression in normal, hyperplastic, and neoplastic prostate tissue. J Urol Pathol 1994; 3: 171-27
45. Sharer LR. Pathology of HIV-1 infection of the central nervous system (Review). J Neuropathol Exp Neurol 1992; 51: 3-11
46. Sharer LR, Epstein LG, Cho E-S et al. Pathologic features of AIDS encephalopathy in children: evidence for LAV/HTLV-III infection of brain. Hum Pathol 1986; 17: 271-84
47. Talley A, Dewhurst S, Perry S et al. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crm A. Mol Cell Biol 1995; 15: 2359-66
48. Tenhula WN, Xu SZ, Madigan MC, Heller K, Freeman WF, Sadun AA. Morphometric comparisons of optic nerve axon loss in acquired immunodeficiency syndrome. Am J Ophthalmol 1992; 15: 14-20
49. Wijsman JH, Jonker RR, Keijzer R, Van De Velse JH, Cornelisse CJ, Van Dierendonck JH. A new method to detect apoptosis in paraffin sections: in situ end-labelling of fragmented DNA. J Histochem Cytochem 1993; 41: 7-12
50. Wiley CA, Masliah E, Morey M et al. Neocortical damage during HIV infection. Ann Neurol 1991; 29: 651-7
51. Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MBA. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci USA 1986; 83: 7089-93