Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats

Journal of Neuroscience

Volumn 17, Issue 23, 1997, Pages 9172-9182

  Clark, Robert S B ^a,b   Chen, Jun ^b   Watkins, Simon C ^a   Kochanek, Patrick M ^a,b   Chen, Minzhi ^a   Stetler, R Anne ^b   Loeffert, J Eric ^a   Graham, Steven H ^b,c,d  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

^d NONE   (United States)

Author keywords

Apoptosis; bcl 2; Hippocampus; Neuron; Rat; Traumatic brain injury

Indexed keywords

PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR SUPPRESSOR GENE;

EID: 0030690119     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-23-09172.1997     Document Type: Article

References (20)

1. Allsopp TE, Wyatt S, Paterson HF, Davies AM (1993) The protooncogcne bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73:295-307.
2. Batistatou A, Merry DE, Korsmeyer SJ, Greene LA (1993) bcl-2 affects survival but not neuronal differentiation of PC12 cells. J Neurosci 13:4422-4428.
3. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Munez G, Thompson CB (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608.
4. Charriaut-Marlangue C, Ben-Ari Y (1995) A cautionary note on the use of TUNEL stain to determine apoptosis. NeuroReport 7:61-64.
5. Chen J, Graham SH, Chan PH, Lan J, Zhou RL, Simon RP (1995) bcl-2 is expressed in neurons that survive focal ischemia in the rat. NeuroReport 6:394-398.
6. Chen J, Zhu RL, Nakayama M, Kawaguchi K, Jin K, Steiler RA, Simon RP, Graham SH (1996) Expression of the apoptosis-effector gene, bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia. J Neurochem 67:64-71.
7. Chen J, Graham SH, Nakayama M, Zhu RL, Jin K, Stetler RA, Simon RP (1997) Apoptosis repressor genes bcl-2 and bcl-x-long are expressed in the rat brain following global ischemia. J Cereb Blood Flow Metab 17:2-10.
8. 0 T-cells. Cytometry 14:883-890.
9. Clark RSB, Kochanek PM, Dixon CE, Chen M, Heineman S, Marion DW, DeKosky ST, Graham SH (1997) Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats. J Neurotrauma 14:179-189.
10. Cortez SC, Mcintosh TK, Noble LJ (1989) Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Res 482:271-282.
11. Deitrich WD, Alonso O, Busto R, Globus MYT, Ginsberg MD (1994) Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat. Acta Neuropathol 87:250-258.
12. Deshpande J, Bergstedt K, Linden T, Kalimo H, Wieloch T (1992) Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death. Exp Brain Res 88:91-105.
13. Steller H (1995) Mechanisms and genes of cellular suicide. Science 267:1445-1449.
14. Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442.
15. Wu D, Wallen HD, Nunez G (1997) Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275:1126-1129.
16. Yakovlev AG, Knoblach SM, Rosenthal D, Smulson M, Faden AI (1996) Upregulation of CPP32 cysteine protease associated with apoptosis in rat cortex following traumatic brain injury. Soc Neurosci Abstr 22:20.
17. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T-I, Jones DP, Wang X (1997) Prevention of apoptosis by bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132.
18. Yin X-M, Oltvai ZN, Korsmeyer SJ (1994) BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax. Nature 369:321-323.
19. Young W (1992) Role of calcium in central nervous system injuries. J Neurotrauma 9:S9-S25.
20. Zhong L-T, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH, Bredesen DE (1993) bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA 90:4533-4537.