Distribution of β-amyloid precursor and B-cell lymphoma protooncogene proteins in the rat retina after optic nerve transection or vascular lesion

Journal of Neuropathology and Experimental Neurology

Volumn 55, Issue 10, 1996, Pages 1073-1182

  Chen, Shur Tzu ^a   Gentleman, Stephen M ^b   Garey, Laurence J ^b   Jen, Ling Sun ^b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Amyloid beta Protein precursor; bcl 2; Immunocytochemistry; Lesion; Optic nerve; Rat; Retina

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ONCOPROTEIN; PROTEIN BCL 2;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA; BLOOD VESSEL INJURY; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; GENE EXPRESSION REGULATION; MOUSE; MUELLER CELL; NERVE FIBER TRANSECTION; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTO ONCOGENE; RETINA NERVE CELL;

EID: 0029845943     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199610000-00007     Document Type: Article

References (53)

1. Kang J, Lemaire HG, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987;325:733-36
2. Selkoe DJ, Amyloid β-protein precursor: New clues to the genesis of Alzheimer's disease. Curr Opin Neurobiol 1994;4:708-16
3. Selkoe DJ. Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci 1993;16: 403-8
4. Amaratunga A, Fine RE. Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve. J Biol Chem 1995;270:17268-72
5. Loffler KU, Edward DP, Tso MOM. Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. Invest Ophthalmol Vis Sci 1995;36:24-31
6. Chen ST, Garey LJ, Jen LS. Bcl-2 proto-oncogene protein immunoreactivity in normal developing and axotomised rats retinas. Neurosci Lett 1994;172:11-14
7. Grosche J, Hartig W, Reichenbach A. Expression of glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and Bcl-2 protooncogene protein by Müller (glial) cells in retinal light damage of rats. Neurosci Lett 1995;185:119-22
8. Allsopp TE, Wyatt S, Paterson HF Davies AM. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 1993;73:295-307
9. Garcia I, Martinou I, Tsujimoto Y, Martinou J-C. Prevention of programmed cell death of sympathetic neurons by the bcl-2 protooncogene. Science 1992;258:302-24
10. Reed JC. Bcl-2 and regulation of programmed cell death. J Cell Biol 1994;124:1-6
11. Satou T, Cummings BJ, Cotman CW. Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity. Brain Res 1995;697:35-43
12. O'Barr S, Schultz J, Rogers J. Expression of the protooncogene bcl-2 in Alzheimer's disease brain. Neurobiol Aging 1996;17:131-36
13. Chen ST, Garey LJ, Jen LS. Expression of β-APP in the rat retina under different experimental conditions. Soc Neurosci Abstr 1994;20:560
14. Morin PJ, Abraham CR, Amaratunga A, et al. Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolised. J Neurochem 1993;61:464-73
15. Gray CW, Patel AJ. Induction of β-amyloid precursor protein isoform mRNAs by bFGF in astrocytes. NeuroReport 1993;4:811-14
16. Topper R, Gehrmann J, Banati R, et al. Rapid appearance of β-amyloid precursor protein immunoreactivity in glial cells following excitotoxic brain injury. Acta Neuropathol 1995;89:23-28
17. Banati RB, Gehrmann J, Kreutzberg GW. Glial β-amyloid precursor protein: Expression in the dentate gyrus after entorhinal cortex lesion. NeuroReport 1993;5:520-25
18. Banati RB, Gehrmann J, Czech C, et al. Early and rapid de novo synthesis of Alzheimer βA4-amyloid precursor protein (APP) in activated microglia. Glia 1993;9:199-210
19. Gray CW. Patel AJ. Regulation of β-amyloid precursor protein isoform mRNAs by transforming growth factor-b1 and interleukin-1β in astrocytes. Mol Brain Res 1993;19:251-56
20. Griffin WS, Sheng JG, Gentleman SM, Graham DI, Mrak RE, Roberts GW. Microglial interleukin-1a expression in human head injury: Correlations with neuronal and neuritic β-amyloid precursor protein expression. Neurosci Lett 1994; 176:133-36
21. Hengartner MD, Horvitz HR. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 1994;76:665-76
22. Dubois-Dauphin M, Frankowski H, Tsujimoto Y, Huarte J, Martinou JC. Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc Natl Acad Sci 1994;91:3309-13
23. Zhong LT, Kane DJ, Bredesen D. Bcl-2 blocks glutamate toxicity in neural cell lines. Mol Brain Res 1993;19:353-55
24. Chen ST, von Bussmann KA, Garey LJ, Jen LS. Protein gene product 9.5 immunoreactive retinal neurons in normal and developing rats and rats with optic nerve or tract lesions. Dev Brain Res 1994;78:265-72
25. Shu D, Ju G, Fan L. The glucose-oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci Lett 1988;85:169-71
26. Multhaup G, Schlicksupp A, Hesse L, et al. The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I). Science 1996;271:1406-9
27. Hollander H, Makarov F, Dreher Z, van Driel D, Chan-Ling T, Stone J. Structure of the macroglia of the retina: Sharing and division of labour astrocytes and Müller cells. J Comp Neurol 1991;313:587-603
28. Stone J, Makarov F, Hollander H, The glial ensheathment of the soma and axon hillock of retinal ganglion cells. Vis Neurosci 1995;12:273-79
29. Newman EA. Regulation of potassium levels by glial cells in the retina. Trends Neurosci 1985;7:156-59
30. Newman EA. Distribution of potassium conductance in mammalian Müller (glial) cells: A comparative study. J Neurosci 1987;7:2423-32
31. + currents via inward rectifying channels in Müller (glial) cells in normal retina and after cutting the optic nerve. Soc Neurosci Abstr 1995;21:1073
32. Lu B, Yokoyama M, Dreyfus CF, Black IB. Depolarising stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons. Proc Natl Acad Sci 1991;88:6289-92
33. Tolon RM, Franco FS, Teresa de los Frailes M, Lorenzo MJ, Cacicedo L. Effect of potassium-induced depolarisation on somatostatin gene expression in cultured fetal rat cerebrocortical cells. J Neurosci 1994;14:1053-59
34. Etcheberrigaray R, Ito E, Oka K, Tofel-Grehl B, Gibson GE, Alkon DL. Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease. Proc Natl Acad Sci 1993;90:8209-13
35. + channels is reduced in β-amyloid injected rats. Soc Neurosci Abst 1995;21:1010
36. Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci 1994;91:10625-29
37. Ehinger B. Glial and neuronal uptake of GABA, glutamic acid, glutamine and glutathione in the rabbit retina. Exp Eye Res 1977;25:221-34
38. Pow DV, Robinson SR. Glutamate in some retinal neurons is derived solely from glia. Neuroscience 1994;60:355-66
39. Riepe RE, Norenberg MD. Müller cells localisation of glutamine synthetase in rat retina. Nature 1977;268:654-55
40. Szatkowski M, Barbour B, Attwell D. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 1990;348:443-46
41. Mattson MR, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of β-amyloid precursor protein. Neuron 1993;10:243-54
42. Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci 1994;14:4368-74
43. Dreher B, Dreher Z, Huxlin KR, Schulz M, Burker W. Müller cells in adult rats and cats show clear reactivity to vitreal disturbance, optic nerve crush or optic nerve pressure-block. J Brain Res (in press)
44. Chen J, Graham SH, Chan PH, Lan J, Zhou RL, Simon RP. bcl-2 is expressed in neurons that survive focal ischemia in the rat. NeuroReport 1995;6:394-95
45. Shimazaki K, Ishida A, Kawai N, Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus. Neurosci Res 1994;20:95-99
46. Szatkowski M, Attwell D. Triggering and execution of neuronal death in brain ischaemia: Two phases of glutamate release by different mechanisms. Trends Neurosci 1994;17:359-65
47. Scott JN, Parhad IM, Clark AW. β-amyloid precursor protein gene is differentially expressed in axotomised sensory and motor system. Mol Brain Res 1991;10:315-25
48. Sola C, Garcia-Ladona FJ, Sarasa M, et al. βAPP gene expression is increased in the rat brain after motor neurons axotomy. Eur J Neurosci 1993;5:795-808
49. Bonfanti L, Chierzi S, Cenni MC, et al. Survival of retinal ganglion cells over-expressing Bcl-2 protein in neonatal transgenic mice following optic nerve section. Soc Neurosci Abstr 1995;21:1556
50. Lewen A, Li GL, Nilsson P. Olsson Y, Hillered L. Traumatic brain injury in rat produces changes of β-amyloid precursor protein immunoreactivity. NeuroReport 1995;6:357-60
51. Yamamoto K, Miyoshi T, Yae T, et al. The survival of rat cerebral cortical neurons in the presence of trophic APP peptides. J Neurobiol 1994;25:585-94
52. Gentleman SM, Graham DI, Roberts GW. Molecular pathology of head trauma: Altered βAPP metabolism and aetiology of Alzheimer's disease. Kogure K, Hossmann KA, Siesjo BK, eds. Prog Brain Res 1993;96:237-46
53. Gentleman SM, Nash MJ, Sweeting CJ, Graham DI, Roberts GW. β-amyloid precursor protein (βAPP) as a marker for axonal injury after head injury. Neurosci Lett 1993;160:139-44