Bcl-2, Bax, and Bcl-x expression in the CA1 area of the hippocampus following transient forebrain ischemia in the adult gerbil

Experimental Brain Research

Volumn 121, Issue 2, 1998, Pages 167-173

  Ferrer, I ^a,b   Lopez E ^a   Blanco, R ^a   Rivera, R ^a   Ballabriga, J ^a   Pozas, E ^a   Marti E ^b  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Bax; Bcl 2; Bcl x; Delayed cell death; Gerbil; Global ischemia

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; FOREBRAIN; GERBIL; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOTTING, WESTERN; CELL DEATH; GERBILLINAE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; ISCHEMIC ATTACK, TRANSIENT; MALE; PROSENCEPHALON; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REFERENCE VALUES; TIME FACTORS;

EID: 0031808675     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050448     Document Type: Article

References (30)

1. Alonso G, Guillemain J, Dumoulin A, Privat A, Patey G (1997) Immunolocalization of Bcl-xl/S in the central nervous system of neonatal and adult rats. Cell Tissue Res 288:59-68
2. Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Núñez G, Thompson CB (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608
3. Castrén E, Ohga Y, Berzaghi MP, Tzimagiorgis G, Thoenen H, Lindholm D (1994) bcl-2 messenger RNA is localized in neurons of the developing and adult rat brain. Neuroscience 61:165-177
4. Chen J, Graham SH, Chan PH, Lan J, Zhou RL, Simon RP (1995) bcl-2 is expressed in neurons that survive focal ischemia in the rat. Neuroreport 6:394-398
5. Chen J, Zhu RL, Nakayama M, Kawaguchi K, Jin K, Stetler RA, Simon RP, Graham SH (1996) Expression of the apoptosiseffector gene bax is up-regulated in vulnerable hippocampal neurons following global ischemia. J Neurochem 67:64-71
6. Davies JC (1995) The Bcl-2 family of proteins, and the regulation of cell survival. Trends Neurosci 18:355-358
7. Ferrer I, Tortosa A, Condom E, Blanco R, Macaya A, Planas AM (1994a) Increased expression of Bcl-2 immunoreactivity in the developing cerebral cortex of the rat. Neurosci Lett 179:13-16
8. Ferrer I, Tortosa A, Macaya A, Sierra A, Moreno D, Munell F, Blanco R, Squier MV (1994b) Evidence of nuclear DNA fragmentation following hypoxia-ischemia in the infant rat brain, and transient forebrain ischemia in the adult gerbil. Brain Pathol 4:115-122
9. Frankowski H, Missotten M. Fernández P-A, Martinou I, Michel P, Sadoul R, Martinou J-C (1995) Function and expression of bcl-x gene in the developing and adult nervous system. Neuroreport 6:1917-1921
10. González-García M, Pérez-Ballestero R, Ding L, Duan L, Boise LH, Thompson CB, Núǹez G (1994) bcl-xL is the major bcl-x mRNA form expressed during murine development and its product localizes in mitochondria. Development 120:3033-3042
11. González-García M, García I. Ding L, O'Shea S, Boise LH, Thompson CB, Núñez G (1995) bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc Natl Acad Sci USA 92:4304-4308
12. Guillardon F, Lenz C, Waschke KF, Krajewski S, Reed JC, Zimmermann M, Kuschinsky W (1996) Altered expression of Bcl-2, Bcl-x, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. Brain Res Mol Brain Res 40:254-260
13. Hara A, Iwai T, Niwa M, Uematsu T, Yoshimi N, Tanaka T, Mori H (1996) Immunohistochemical detection of Bax and Bcl-2 proteins in gerbil hippocampus following transient forebrain ischemia. Brain Res 711:249-253
14. Hara H, Sakamoto T, Kogure K (1993) Mechanisms and pathogenesis of ischaemia-induced neuronal damage. Prog Neurobiol 40:645-670
15. Hockenberry D, Núñez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336
16. Honkaniemi J, Massa S, Breckinridge M, Sharp FR (1996) Global ischemia induces apoptosis-associated genes in hippocampus. Brain Res Mol Brain Res 42:79-88
17. Ito U, Spatz M, Walker JT, Klatzo I (1975) Experimental cerebral ischemia in Mongolian gerbils. I. Light microscopical observations. Acta Neuropathol 32:209-223
18. Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239:57-69
19. Krajewski S, Krajewska M, Shabaik A, Miyashita T. Wang HG, Reed JC (1994a) Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 145:1323-1336
20. Krajewski S, Krajewska M, Shabaik A, Wang H-G. Irie S, Fong L, Reed JC (1994b) Immunohistochemical analysis of in vivo patterns of bcl-x expression. Cancer Res 54:5501-5507
21. Krajewski S, Mai JK, Krajewska M, Sikorska A, Mossakowski MJ, Reed JC (1995) Upregulation of Bax protein levels in neurons following cerebral ischemia. J Neurosci 15:6364-6376
22. Linnik MD, Zahos P, Geschwind MD, Federoff HJ (1995) Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke 26:1670-1674
23. Martinou J-C, Dubois-Dauphin M, Staple JK, Rodríguez I, Frankowski H, Missotten M, Albertini P, Talabot D, Catsicas S, Pietra C, Huarte J (1994) Overexpression of bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13:1017-1030
24. Merry DE, Korsmeyer SJ (1997) bct-2 gene family in the nervous system. Annu Rev Neurosci 20:245-267
25. Merry DE, Veis DJ, Hickey WF, Korsmeyer SJ (1994) Bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 130:301-311
26. Minn AJ, Boise LH, Thompson CB (1996) Bcl-x(S) antagonizes the protective effects of Bcl-x(L). J Biol Chem 271:6306-6312
27. Nitsch C (1992) Reorganization in the gerbil hippocampus after ischemia-induced delayed neuronal death: fate of parvalbumin-containing neurons. In: Ito U, Kirino T, Kuroiwa T, Klatzo I (eds) Maturation phenomenon in cerebral ischemia. Springer, Berlin Heidelberg New York, pp 23-31
28. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
29. Shimazaki K, Ishida A, Kawai N (1994) Increase in Bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus. Neurosci Res 20:95-99
30. Tortosa A, Ferrer I (1993) Parvalbumin immunoreactivity in the hippocampus of the gerbil after transient forebrain ischemia: a qualitative and quantitative sequential study. Neuroscience 55:33-43