Toward an understanding of the molecules that sense myocardial ischemia

Annals of the New York Academy of Sciences

Volumn 940, Issue , 2001, Pages 96-109

  Benson, Christopher J ^a   Sutherland, Stephani P ^b  

^a UNIVERSITY OF IOWA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cardiac afferents; ENaC Deg ion channel; Myocardial ischemia protons

Indexed keywords

ION CHANNEL; SODIUM CHANNEL; SODIUM ION; VANILLOID RECEPTOR;

ANGINA PECTORIS; CELL ACTIVATION; CONFERENCE PAPER; HEART MUSCLE ISCHEMIA; HEART NERVE; HUMAN; HUMAN TISSUE; ION CURRENT; PATCH CLAMP; PH; SENSORY NERVE CELL; SYMPATHETIC NERVE;

ANGINA;

EID: 0034938021     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03669.x     Document Type: Conference Paper

References (55)

1. Pain in muscular ischemia: Its relation to anginal pain
2. A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain
3. Search for a cardiac nociceptor: Stimulation by bradykinin of sympathetic afferent nerve endings in the heart of the cat
4. A model of cardiac nociception in chronically instrumented rats: Behavioral and electrophysiological effects of pericardial administration of algogenic substances
5. Lack of a role of adenosine in activation of ischemically sensitive cardiac sympathetic afferents
6. Reflex sympathoexcitation by cardiac sympathetic afferents during myocardial ischemia. Role of adenosine
7. Adenosine activates cardiac sympathetic afferent fibers and potentiates the excitation induced by coronary occlusion
8. Polysensory response characteristics of dorsal root ganglion neurones that may serve sensory functions during myocardial ischaemia
9. Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation
10. Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons
11. Phosphorus nuclear magnetic resonance of perfused working rat hearts
12. The time of onset and severity of acidosis in myocardial ischaemia
13. Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats
14. Continuous coronary sinus and arterial pH monitoring during pacing-induced ischaemia in coronary artery disease
15. A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro
16. Pain due to tissue acidosis: A mechanism for inflammatory and ischemic myalgia?
17. Acid-induced excitation of afferent cardiac sympathetic nerve fibers
18. Isolation and culture of rat sensory neurons having distinct sensory modalities
19. Convergence of sensory processes from the heart and left ulnar nerve onto a single afferent perikaryon: A neuroanatomical study in the rat employing fluorescent tracers
20. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
21. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice
22. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors
23. A P2X purinoceptor expressed by a subset of sensory neurons
24. +-gated cation channels: Neuronal acid sensors in the ENaC/DEG family of ion channels
25. 3 receptor, a serotonin-gated ion channel
26. The capsaicin receptor: A heat-activated ion channel in the pain pathway
27. A capsaicin-receptor homologue with a high threshold for noxious heat
28. Protons activate a cation conductance in a sub-population of rat dorsal root ganglion neurones
29. A receptor for protons in the nerve cell membrane
30. Proton-induced transformation of calcium channel in chick dorsal root ganglion cells
31. The cloned capsaicin receptor integrates multiple pain-producing stimuli
32. Impaired nociception and pain sensation in mice lacking the capsaicin receptor
33. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
34. Epithelial sodium channels: Function, structure, and regulation
35. Molecular modeling of mechanotransduction in the nematode Caenorhabditis elegans
36. The mammalian sodium channel BNC1 is required for normal touch sensation
37. A proton-gated cation channel involved in acid-sensing
38. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
39. A sensory neuron-specific, proton-gated ion channel
40. + channel
41. The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans
42. A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells
43. + channel specific for sensory neurons
44. + channels
45. + and lactate ions
46. + derived from lactic acid and hypercapnia
47. ASIC3 matches the acid-gated current in cardiac ischemia-sensing neurons
48. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties
49. Protons: Small stimulants of capsaicin-sensitive sensory nerves
50. Haemodynamic response to myocardial ischaemia during unrestricted activity, exercise testing, and atrial pacing assessed by ambulatory pulmonary artery pressure monitoring
51. Pain and myocardial ischemia: The role of sympathetic activation
52. The neurohumoral axis in congestive heart failure
53. Clinical neurocardiology: Arrhythmias
54. Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans
55. Cardiovascular reflex responses to ischemia during occlusion of celiac and/or superior mesenteric arteries