Evidence for mediation by endothelium-derived hyperpolarizing factor of relaxation to bradykinin in the bovine isolated coronary artery independently of voltage-operated Ca2+ channels

British Journal of Pharmacology

Volumn 117, Issue 6, 1996, Pages 1035-1040

  Drummond, G R ^a   Cocks, T M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Bradykinin; Endothelium derived hyperpolarizing factor; L type voltage operated Ca2+ channels; NG nitro L arginine resistant relaxations; Nifedipine

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; BRADYKININ; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; INDOMETACIN; LEMAKALIM; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE; NIFEDIPINE; NITRIC OXIDE; OXYHEMOGLOBIN; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CATTLE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; DRUG MECHANISM; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL FACTORS; BRADYKININ; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CATTLE; CORONARY VESSELS; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NIFEDIPINE; NITRIC OXIDE SYNTHASE; NITROARGININE;

EID: 0029919610     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16693.x     Document Type: Article

References (25)

1. +]: A functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed. J. Cardiovasc. Pharmacol., 21, 423-429.
2. ANGUS, J.A. & BRAZENOR, R.M. (1983). Relaxation of large coronary artery by verapamil, D600, and nifedipine is constrictor selective: comparison with glyceral trinitrate. J. Cardiovasc. Pharmacol., 5, 321-328.
3. BENY, J-L. & VON DER WEID, P-Y. (1991). Hyperpolarizing factors. Coronary Artery Dis., 2, 300-306.
4. CHEN, G. & SUZUKI, H. (1989). Some electrical properties of the endothelium dependent hyperpolarization recorded from rat arterial smooth muscle cells. J. Physiol., 410, 91-106.
5. COWAN, C.L., PALACINO, J.J., NAJIBI, S. & COHEN, R.A. (1993). Potassium channel-mediated relaxation to acetylcholine in rabbit arteries. J. Pharmacol. Exp. Ther., 266, 1482-1489.
6. 2 kinin receptors in the bovine isolated coronary artery. Br. J. Pharmacol., (in press).
7. EDWARDS, G. & WESTON, A.H. (1993). The pharmacology of ATP-sensitive potassium channels. Annu. Rev. Pharmacol. Toxicol., 33, 597-637.
8. GARLAND, C.J., PLANE, F., KEMP, B.K. & COCKS, T.M. (1995). Endothelium-dependent hyperpolarization: a role in the control of vascular tone. Trends Pharmacol. Sci., 16, 23-30.
9. + channels. Trends Pharmacol. Sci., 16, 1-5.
10. HOLZMANN, S., KUKOVETZ, W.R., WINDISCHHOFER, W., PASCHKE, E. & GRAIER, W.F. (1994). Pharmacologic differentiation between endothelium-dependent relaxations sensitive and resistant to nitro-L-arginine in coronary arteries. J. Cardiovasc. Pharmacol., 23, 747-756.
11. G-nitro-L-arginine (L-NNA) with the onset of pulmonary hypertension. Br. J. Pharmacol., (in press).
12. KILPATRICK, E.V. & COCKS, T.M. (1994). Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium-dependent relaxation of pig isolated coronary artery. Br. J. Pharmacol., 112, 557-565.
13. KOMORI, K & VANHOUTTE, P.M. (1990). Endothelium-derived hyperpolarizing factor. Blood Vessels, 27, 238-245.
14. KÜHBERGER, E., GROSCHNER, K., KUKOVETZ, W.R. & BRUNNER, F. (1995). The role of myoendothelial cell contact in non-nitric oxide, non prostanoid-mediated endothelium-dependent relaxation of porcine coronary artery. Br. J.Pharmacol., (in press).
15. KÜHBERGER, E., KUKOVETZ, W.R. & GROSCHNER, K. (1993). Cromakalim inhibits multiple mechanisms of smooth muscle activation with similar stereoselectivity. J. Cardiovasc. Pharmacol., 21, 946-954.
16. 2 analogue U-44069. Am. J. Physiol., 241, C243-C249.
17. MARTIN, W., SMITH, J.A. & WHITE, D.G. (1986). The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide, or bovine retractor penis inhibitory factor. Br. J. Pharmacol., 89, 563-571.
18. G-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br. J. Pharmacol., 99, 408-412.
19. NAGAO, T. & VANHOUTTE, P.M. (1992). Hyperpolarization as a mechanism for endothelium-dependent relaxations in the porcine coronary artery. J. Physiol., 445, 355-367.
20. PRITCHARD, K.A., TOTA, R.R., STEMERMAN, M.B. & WONG, P.W-Y. (1990). 14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. Biochem. Biophys. Res. Commun., 167, 137-142.
21. ROSOLOWSKY, M., FALCK, J.R. & CAMPBELL, W.B. (1990). Synthesis and biological activity of epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells. Adv. Prostaglandin Thromboxane Leukot. Res., 21, 213-216.
22. TAYLOR, S.G. & WESTON, A.H. (1988). Endothelium-derived hyperpolarizing factor: a new endogenous inhibitor from the vascular endothelium. Trends Pharmacol. Sci., 9, 272-274.
23. WALDRON, G.J. & GARLAND, C.J. (1994). Contribution of both nitric oxide and a change in membrane potential to acetylcholine-induced relaxation in rat small mesenteric artery. Br. J. Pharmacol., 112, 831-836.
24. YAMAGISHI, T., YANAGISAWA, T. & TAIRA, N. (1992a). Activation of phospholipase C by the agonist U46619 is inhibited by cromakalim-induced hyperpolarization in porcine coronary artery. Biochem. Biophys. Res. Commun., 187, 1517-1522.
25. + channel openers, cromakalim and K14032, inhibit agonist-induced release in canine coronary artery. Naunyn-Schmied. Arch. Pharmacol., 346, 691-700.