Oxidative stress-dependent release of mitochondrial cytochrome c after traumatic brain injury

Journal of Cerebral Blood Flow and Metabolism

Volumn 21, Issue 8, 2001, Pages 914-920

  Lewen A ^a   Fujimura, M ^a   Sugawara, T ^a   Matz, P ^a   Copin, J C ^a   Chan, P H ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Aconitase; Cell death; Head injury; Outcome; Reactive oxygen species; SOD2

Indexed keywords

CYTOCHROME C; DNA FRAGMENT; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL ENZYME; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN MITOCHONDRION; CELL DEATH; CONTROLLED STUDY; CYTOSOL; ENZYME RELEASE; GENE EXPRESSION; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; WESTERN BLOTTING;

EID: 0034906651     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200108000-00003     Document Type: Article

References (38)

1. Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria
2. Cytochrome c release and caspase activation in traumatic axonal injury
3. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss
4. The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism
5. Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide
6. Apoptosis suppressor gene bcl-2 expression after traumatic brain injury in rats
7. Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: Possible role in spatial memory deficits
8. Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase
9. Preparation and assay of superoxide dismutases
10. A controlled cortical impact model of traumatic brain injury in the rat
11. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
12. Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats
13. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
14. The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice
15. Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation
16. Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not
17. Nitric oxide induces tyrosine nitration and release of cytochrome c preceding an increase of mitochondrial transmembrane potential in macrophages
18. Bax directly induces release of cytochrome c from isolated mitochondria
19. Intracellular adenosine trisphosphate (ATP) concentration: A switch in the decision between apoptosis or necrosis
20. Difference between apoptotic and necrotic cell death by means of the BM cell death detection ELISA or annexin V staining
21. Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scavenger treatment in experimental traumatic brain injury
22. Cell-specific induction of apoptosis by microinjection of cytochrome c
23. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor Tr3
24. Cytoohrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
25. Induction of apoptotic program in cell-free extracts: Requirements for dATP and cytochrome c
26. Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain
27. Increased cytochrome c-mediated DNA fragmentation and cell death in manganese-superoxide dismutase-deficient mice after exposure to subarachnoid hemolysate
28. Release of mitochondrial cytochrome c and DNA fragmentation after cold injury-induced brain trauma in mice: Possible role in neuronal apoptosis
29. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
30. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia
31. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
32. Intracellular ATP, a switch in the decision between apoptosis and necrosis
33. Traumatic brain injury alters the molecular fingerprint of TUNEL-positive cortical neurons in vivo: A single-cell analysis
34. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat
35. A comparative study of apoptosis and necrosis in HepG2 cells: Oxidant-induced caspase inactivation leads to necrosis
36. Regulation of pituitary adenylate cyclase activating polypeptide and its receptor type 1 after traumatic brain injury: Comparison with brain derived neurotrophic factor and the induction of neuronal cell death
37. Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia
38. Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome C