Increased cytochrome c-mediated DNA fragmentation and cell death in manganese-superoxide dismutase-deficient mice after exposure to subarachnoid hemolysate

Stroke

Volumn 32, Issue 2, 2001, Pages 506-515

  Matz, Paul G ^a,b   Fujimura, Miki ^a   Lewen, Anders ^a   Morita Fujimura, Yuiko ^a   Chan, Pak H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Hemoglobin; Iron; Mice; Stroke, experimental; Subarachnoid hemorrhage; Superoxide dismutase

Indexed keywords

CYTOCHROME C; DNA FRAGMENT; HEMOGLOBIN; IRON; MANGANESE SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CYTOSOL; ENZYME LOCALIZATION; HEMOLYSATE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; MALE; MOUSE; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; STROKE; SUBARACHNOID HEMORRHAGE;

EID: 0035137427     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.32.2.506     Document Type: Article

References (40)

1. Oxidative stress in the human brain after subarachnoid hemorrhage
2. Anti-oxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/ HSP32, HSP47) following subarachnoid injections of lysed blood
3. Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase
4. A review of hemoglobin and the pathogenesis of cerebral vasospasm
5. Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin
6. The involvement of iron in lipid peroxidation
7. The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation
8. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
9. Endothelial -cell heme uptake from heme proteins: Induction of sensitization and desensitization to oxidant damage
10. Neurotoxicity of hemoglobin in cortical cell culture
11. Superoxide production in experimental brain injury
12. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/ superoxide in cortical cell cultures
13. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
14. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury
15. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
16. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion
17. In situ detection of AP sites and DNA strand breaks bearing 3′ -phosphate termini in ischemic mouse brain
18. Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain
19. Oxidative phosphorylation and photophosphorylation
20. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
21. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2,-3,-6,-7,-8,-10 in a caspase-9-dependent manner
22. Evidence for apoptosis after intracerebral hemorrhage in rat striatum
23. Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain
24. Subaracbnoid injections of lysed blood induce the hsp70 stress gene and produce DNA fragmentation in focal areas of the rat brain
25. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
26. Studies of neuronal injury mechanism in focal stroke using mitochondrial manganese superoxide dismutase-deficient mice
27. Preparation and assay of superoxide dismutases
28. Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats
29. Nitric oxide induces tyrosine nitration and release of cytochrome c preceding an increase of mitochondrial transmembrane potential in macrophages
30. Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia
31. The cellular reactions to experimental intracerebral hemorrhage
32. A cautionary note on the use of the TUNEL stain to determine apoptosis
33. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat
34. Cerebral ischemia produces laddered DNA fragments distinct from cardiac ischemia and archetypal apoptosis
35. Superoxide in apoptosis: Mitochondrial generation triggered by cytochrome c loss
36. Chemistry of reactive oxygen species
37. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
38. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
39. Subarachnoid hemorrhage in the rat: Angiography and fluorescent microscopy of the major cerebral arteries
40. Factors affecting excitatory amino acid release following severe human head injury