Identification of the gene immediately downstream of the murine INK4a/ARF locus

Experimental Gerontology

Volumn 36, Issue 8, 2001, Pages 1289-1302

  Pantoja, Cristina ^a   Palmero, Ignacio ^a   Serrano, Manuel ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Knock out; Lipopolysaccharide; p16INK4a; p19ARF; Tumor suppressors

Indexed keywords

ANIMAL CELL; ARTICLE; CANCER INHIBITION; EXON; FIBROBLAST; GENE EXPRESSION; GENE LOCUS; GENE STRUCTURE; GENE TRANSFER; GENETIC TRANSCRIPTION; KNOCKOUT GENE; MOUSE; MUTATION; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CHIMERA; CHROMOSOME MAPPING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA PRIMERS; DNA, COMPLEMENTARY; EXONS; GENE EXPRESSION; GENES, P16; GENES, TUMOR SUPPRESSOR; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION;

MURINAE;

EID: 0034905044     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(01)00104-8     Document Type: Article

References (37)

1. ARF links the tumor suppressors Rb and p53
2. INK4d
3. ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumour suppressor p53
4. INK4a and the control of cellular proliferative life span
5. Secretory leukocyte protease inhibitor: A macrophage product induced by and antagonistic to bacterial lipopolysaccharide
6. ARF
7. Tumor spectrum in ARF-deficient mice
8. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
9. 9p21 deletion correlates with recurrence in head and neck cancer
10. Expression of p16(INK4A) and alterations of the 9p21-23 chromosome region in non-small-cell lung carcinomas: relationship with tumor growth parameters and ploidy status
11. mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription
12. INK4A expression in normal human adult and infant tissues
13. Genomic cloning of methylthioadenosine phosphorylase: A purine metabolic enzyme deficient in multiple different cancers
14. Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma
15. ARF links the tumour suppressor p53 to Ras
16. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
17. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
18. ARF
19. INK4a/CDKN2A tumor suppressor and its relatives
20. INK4a
21. ARF tumor suppressor
22. INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC)
23. A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer
24. Role of the INK4a locus in tumor suppression and cell mortality
25. INK4a
26. INK4a
27. The INK4A/ARF locus and its two gene products
28. Tumor surveillance via the ARF-p53 pathway
29. ARF stabilizes p53 by blocking nuclo-cytoplasmic shuttling of Mdm2
30. Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors
31. Nucleolar Arf sequesters Mdm2 and activates p53
32. Cooperative signals governing ARF-Mdm2 interaction and nucleolar localization of the complex
33. The cat and mouse games that genes, viruses, and cells play
34. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair is ability to block nuclear export of MDM2 and p53
35. INK4a tumor suppressor versus other INK4 family members during mouse development and aging
36. Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development
37. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization