Yellow mice, red hair, and childhood obesity: The melanocortinergic pathway in energy homeostasis

Journal of Pediatrics

Volumn 139, Issue 2, 2001, Pages 177-181

  Graham, Kathleen S ^a   Leibel, Rudolph L ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; LEPTIN; MELANIN CONCENTRATING HORMONE; MELANOCORTIN; OREXIN; PROOPIOMELANOCORTIN;

EDITORIAL; ENERGY METABOLISM; ENVIRONMENTAL FACTOR; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; HAIR COLOR; HEREDITY; HUMAN; HYPOTHALAMUS; MEDICAL RESEARCH; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0034902175     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1067/mpd.2001.117574     Document Type: Article

References (43)

1. Pathophysiology of childhood obesity
2. The human obesity gene map: The 2000 update
3. Prader-Willi and other syndromes associated with obesity and mental retardation
4. The molecular genetics of rodent single gene obesities
5. The beneficial effects of body fat and adipose tissue in humans
6. Obesity
7. Congenital leptin deficiency is associated with severe early-onset obesity in humans
8. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
9. A frameshift mutation in human MC4R is associated with a dominant form of obesity
10. A frameshift mutation in MC4R associated with dominantly inherited human obesity
11. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
12. Two polymorphisms in peroxisome proliferator-activated receptor-gamma are associated with severe overweight among obese women
13. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
14. Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children
15. POMC-derived peptides and their biological action
16. Melanocortins and body weight: A tale of two receptors
17. A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors
18. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
19. Molecular characterization of the mouse agouti locus
20. Role of subunit diversity in signaling by heterotrimeric G proteins
21. Inverse agonism at G protein-coupled receptors: (Patho)physiological relevance and implications for drug discovery
22. Molecular structure and chromosomal mapping of the human homolog of the agouti gene
23. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
24. Regulation of the leptin promoter function by Sp1 ,C/EBP, and a novel factor
25. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
26. Systematic mutation screening of the pro-opiomelanocortin gene: Identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes
27. The conformational switch in 7-transmembrane receptors: The muscarinic receptor paradigm
28. Obesity as a neuroendocrine disease: Lessons to be learned from proopiomelanocortin and melanocormtin receptor mutations in mice and men
29. Targeted disruption of the melanocortin-4 receptor results in obesity in mice
30. Leptin and bone: Does the brain control bone biology?
31. The leptin receptor mediates apparent autocrine regulation of leptin gene expression
32. ∂b affects body composition and leptin homeostasis in adult mice
33. Leptin: A molecule integrating somatic energy stores, energy expenditure and fertility
34. Codominant effects of the fatty (fa) gene during early development of obesity
35. Life without neuropeptide Y
36. Endocrine function of neuropeptide Y knockout mice
37. Role of leptin in the neuroendocrine response to fasting
38. Fetal hemoglobin in homozygous sickle cell disease
39. The influence of fetal hemoglobin on the clinical expression of sickle cell anemia
40. Obesity: A growing problem
41. Measuring genome evolution
42. The continuing epidemic of obesity in the United States