Single molecule measurements of titin elasticity

Progress in Biophysics and Molecular Biology

Volumn 77, Issue 1, 2001, Pages 1-44

  Wang, Kuan ^a   Forbes, Jeffrey G ^a,b   Jin, Albert J ^a,c  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

AFM; Atomic force microscopy; Biological forces; Laser optical trap; LOT; Muscle protein; Polymer elasticity

Indexed keywords

CONNECTIN; MUSCLE PROTEIN; PROTEIN KINASE; TENASCIN;

ANIMAL; ATOMIC FORCE MICROSCOPY; CHEMISTRY; COMPARATIVE STUDY; ELASTICITY; FORECASTING; HEART MUSCLE; LABORATORY DIAGNOSIS; LASER; MECHANICAL STRESS; MICROMANIPULATION; MODEL; MUSCLE FUNCTION; NONHUMAN; OPTICAL INSTRUMENTATION; PATHOPHYSIOLOGY; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MOTIF; REVIEW; SKELETAL MUSCLE;

AMINO ACID MOTIFS; ANIMALS; ELASTICITY; FORECASTING; LASERS; MICROCHEMISTRY; MICROMANIPULATION; MICROSCOPY, ATOMIC FORCE; MODELS, CHEMICAL; MUSCLE PROTEINS; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN KINASES; SPECIMEN HANDLING; STRESS, MECHANICAL; TENASCIN;

ANIMALIA;

EID: 0034895411     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0079-6107(01)00009-8     Document Type: Review

References (152)

1. Applications of laser-radiation pressure
2. Forces of a single-beam gradient laser trap on a dielectric sphere in the ray optics regime
3. Obervation of a single-beam gradient force optical trap for dielectric particles
4. Models for the specific adhesion of cells to cells
5. Single-molecule manipulation of double-stranded DNA using optical tweezers: Interaction studies of DNA with RecA and YOYO-1
6. Atomic force microscope
7. Making light work with optical tweezers
8. Nanometers and piconewtons: The macromolecular mechanics of kinesin
9. Estimating the persistence length of a worm-like chain molecule from force-extension measurements
10. Calculation of thermal noise in atomic force microscopy
11. Atomic force microscopy captures length phenotypes in single proteins
12. Mechanical and chemical unfolding of a single protein: A comparison
13. Carbon nanotube atomic force microscopy tips: Direct growth by chemical vapor deposition and application to high-resolution imaging
14. The relationship between ligand-binding thermodynamics and protein-ligand interaction forces measured by atomic force microscopy
15. Thermodynamic and structural consequences of flexible loop deletion by circular permutation in the streptavidin-biotin system
16. A nondestructive method for determining the spring constant of cantilevers for scanning force microscopy
17. Submolecular resolution of single macromolecules with atomic force microscopy
18. Cell membrane mechanics
19. Gold grown epitaxially on mica - Conditions for large area flat faces
20. Fast kinetics and mechanisms in protein folding
21. Protein biophysics - Stretching single protein molecules: Titin is a weird spring
22. Energy landscapes of biomolecular adhesion and receptor anchoring at interfaces explored with dynamic force spectroscopy
23. Looking inside molecular bonds at biological interfaces with dynamic force spectroscopy
24. Dynamic strength of molecular adhesion bonds
25. Strength of a weak bond connecting flexible polymer chains
26. Sensitive force technique to probe molecular adhesion and structural linkages at biological interfaces
27. RNA structure - Pulling on hair(pins)
28. Adhesion forces between individual ligand-receptor pairs
29. Sensing specific molecular-interactions with the atomic-force microscope
30. AFM investigation of native nebulin
31. Atomic force microscope study of the effect of the immobilization substrate on the structure and force-extension curves of a multimeric protein
32. Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity
33. Elastic filaments in skeletal muscle revealed by selective removal of thin filaments with plasma gelsolin
34. The organization of titin filaments in the half sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: A map of ten nonrepetitive epitopes starting at the z line extends close to the m line
35. Steered molecular dynamics simulation of the unfolding of multiple titin immunoglobulin domains
36. Signals and noise in micromechanical measurements
37. Reconstitution of the pore-forming toxin alpha-hemolysin in phospholipid/18-octadecyl-1-thiahexa(ethylene oxide) and phospholipid/n-octadecanethiol supported bilayer membranes
38. How strong is a covalent bond?
39. Mechanical properties of titin isoforms
40. Nonuniform elasticity of titin in cardiac myocytes: A study using immunoelectron microscopy and cellular mechanics
41. Passive tension in cardiac muscle: Contribution of collagen, titin, microtubules, and intermediate filaments
42. Interplay between passive tension and strong and weak binding cross-bridges in insect indirect flight-muscle - A functional dissection by gelsolin-mediated thin filament removal
43. Passive tension and stiffness of vertebrate skeletal and insect flight muscles: The contribution of weak cross-bridges and elastic filaments
44. Identification of new repeating motifs in titin
45. Modular motif, structural folds and affinity profiles of PEVK segment of human fetal skeletal muscle titin
46. Improvements in atomic force microscopy protocols for imaging fibrous proteins
47. Scanning tunneling microscopy and atomic force microscopy: Application to biology and technology
48. Secondary calpain3 deficiency in 2q-linked muscular dystrophy - Titin is the candidate gene
49. Measurement of ligand receptor interactions
50. Characterization of beta-connectin (titin 2) from striated muscle by dynamic light scattering
51. Detection and localization of individual antibody-antigen recognition events by atomic force microscopy
52. The physiological role of titin in striated muscle
53. A physiological role for titin and nebulin in skeletal muscle
54. Elastic behavior of connectin filaments during thick filament movement in activated skeletal muscle
55. Calibration of atomic-force microscope tips
56. Sliding filaments and molecular motile systems
57. Molecular dynamics study of unbinding of the avidin-biotin complex
58. Atomic force microscopy studies of a titin PEVK segment
59. Muscle structure - Molecular bungees
60. Role of titin in nonmuscle and smooth muscle cells
61. Folding-unfolding transitions in single titin molecules characterized with laser tweezers
62. Complete unfolding of the titin molecule under external force
63. Mechanical manipulation of single titin molecules with laser tweezers
64. Stretching single-domain proteins: Phase diagram and kinetics of force-induced unfolding
65. Native topology determines force-induced unfolding pathways in globular proteins
66. Brownian motion in a field of force and the diffusion model of chemical kinetics
67. Forced unfolding of the fibronectin type III module reveals a tensile molecular recognition switch
68. A simple assay for local heating by optical tweezers
69. Titins - Giant proteins in charge of muscle ultrastructure and elasticity
70. Measuring the forces that control protein interactions
71. Direct measurement of the forces between complementary strands of DNA
72. Protein folding: The endgame
73. Titin elasticity in the context of the sarcomere: Force and extensibility measurements on single myofibrils
74. Nature of PEVK-titin elasticity in skeletal muscle
75. Towards a molecular understanding of the elasticity of titin
76. I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure
77. Relationship between stiffness and force in single molecule pulling experiments
78. Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation
79. Steered molecular dynamics simulation of conformational changes of immunoglobulin domain i27 interpret atomic force microscopy observations
80. Steered molecular dynamics simulations of force-induced protein domain unfolding
81. The key event in force-induced unfolding of titin's immunoglobulin domains
82. Polyproline ii helix is a key structural motif of the elastic PEVK segment of titin
83. Titin as a chromosomal protein
84. Stretching DNA
85. Mechanical unfolding intermediates in titin modules
86. Connectin, an elastic protein of striated muscle
87. Connectin/titin, giant elastic protein of muscle
88. Connectin, an elastic protein of muscle. Identification of titin with connectin
89. Single-molecule biomechanics with optical methods
90. Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy
91. Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils
92. Intermolecular forces and energies between ligands and receptors
93. Passive forces in mammalian skeletal muscle: A freely-jointed and worm-like chain
94. The cell biological application of carbon nanotube probes for atomic force microscopy: Comparative studies of malaria-infected erythrocytes
95. Recombination of protein domains facilitated by co-translational folding in eukaryotes
96. Single protein misfolding events captured by atomic force microscopy
97. The molecular elasticity of the extracellular matrix protein tenascin
98. Purification and biochemical characterization of myomesin, a myosin-binding and titin-binding protein, from bovine skeletal muscle
99. Theory of protein folding: The energy landscape perspective
100. Entropic elasticity of single polymer chains of poly(methacrylic acid) measured by atomic force microscopy
101. Forced unfolding of fibronectin type 3 modules: An analysis by biased molecular dynamics simulations
102. Unfolding proteins by external forces and temperature: The importance of topology and energetics
103. Isolation and characterization of titin t1 from bovine cardiac muscle
104. A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules
105. Characterization of biomimetic surfaces formed from cell membranes
106. Reversible unfolding of individual titin immunoglobulin domains by afm
107. Single molecule force spectroscopy on polysaccharides by atomic force microscopy
108. The mechanical stability of immunoglobulin and fibronectin III domains in the muscle protein titin measured by atomic force microscopy
109. Unraveling proteins: A molecular mechanics study
110. Calibration of rectangular atomic force microscope cantilevers
111. Method for the calibration of atomic-force microscope cantilevers
112. Biological atomic force microscopy: What is achieved and what is needed
113. Biological atomic force microscopy: From microns to nanometers and beyond
114. Chaperonin function: Folding by forced unfolding
115. Overstretching b-DNA: The elastic response of individual double-stranded and single-stranded DNA molecules
116. Stretching lattice models of protein folding
117. Skeletal muscle-specific calpain, p94, and connectin/titin: Their physiological functions and relationship to limb-girdle muscular dystrophy type 2a
118. A survey of interactions made by the giant protein titin
119. Stress-induced structural transitions in DNA and proteins
120. Model energy landscapes and the force-induced dissociation of ligand-receptor bonds
121. Biological applications of optical forces
122. Titin: A molecular control freak
123. Titin extensibility in situ: Entropic elasticity of permanently folded and permanently unfolded molecular segments
124. Elastic properties of connecting filaments along the sarcomere
125. Optical tweezer measurements of force and extension in individual titin molecules
126. Elasticity and unfolding of single molecules of the giant muscle protein titin
127. Torsional rigidity of single actin filaments and actin-actin bond breaking force under torsion measured directly by in vitro micromanipulation
128. Indications for a novel muscular dystrophy pathway: Gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin
129. Small cantilevers for force spectroscopy of single molecules
130. Fast imaging and fast force spectroscopy of single biopolymers with a new atomic force microscope designed for small cantilevers
131. Versatile optical traps with feedback control
132. Construction of multiple-beam optical traps with nanometer-resolution position sensing
133. Purification of titin and nebulin
134. Titin/connectin and nebulin: Giant protein rulers of muscle structure and function
135. Titin
136. Regulation of skeletal muscle stiffness and elasticity by titin isoforms: A test of the segmental extension model of resting tension
137. Viscoelasticity of the sarcomere matrix of skeletal muscles: The titin-myosin composite filament is a dual-stage molecular spring
138. Titin: Major myofibrillar components of striated muscle
139. Titin is an extraordinarily long, flexible, and slender myofibrillar protein
140. Titin elasticity: Laser trap measurement of force-extension curves of isolated titin molecules
141. Force and velocity measured for single molecules of RNA polymerase
142. Stretching DNA with optical tweezers
143. Fluorescence spectroscopy of single biomolecules
144. Does titin regulate the length of muscle thick filaments?
145. Direct haplotyping of kilobase-size DNA using carbon nanotube probes
146. Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme
147. Direct measurement of the torsional rigidity of single actin filaments
148. A kinetic molecular model of the reversible unfolding and refolding of titin under force extension
149. Discontinuous gold island films on mica
150. Fluorescence quenching: A tool for single-molecule protein-folding study
151. Single molecule force spectroscopy in biology using the atomic force microscope