Force and velocity measured for single molecules of RNA polymerase

Science

Volumn 282, Issue 5390, 1998, Pages 902-907

  Wang, Michelle D ^a,d   Schnitzer, Mark J ^a   Yin, Hong ^b,e   Landick, Robert ^c   Gelles, Jeff ^b   Block, Steven M ^a  

^a PRINCETON UNIVERSITY   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d Department of Population Medicine and Diagnostic Sciences   (United States)

^e TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KINESIN; MYOSIN; RNA POLYMERASE;

ARTICLE; BASE PAIRING; DNA TRANSCRIPTION; ESCHERICHIA COLI; FEEDBACK SYSTEM; FORCE; GENE TRANSLOCATION; PRIORITY JOURNAL; VELOCITY;

DNA, BACTERIAL; DNA-DIRECTED RNA POLYMERASES; ESCHERICHIA COLI; MATHEMATICS; MODELS, CHEMICAL; MOLECULAR MOTOR PROTEINS; RNA, BACTERIAL; RNA, MESSENGER; TEMPLATES, GENETIC; THERMODYNAMICS; TRANSCRIPTION, GENETIC;

EID: 0032582494     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.282.5390.902     Document Type: Article

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43. Supported by grants from the National Institute of General Medical Sciences (R.L., J.G., and S.M.B), and from NSF and the W. M. Keck Foundation (S.M.B). M.D.W. was supported by a Damon Runyon-Walter Winchell Cancer Research fund postdoctoral fellowship. M.J.S. was supported by an American Heart Association predoctoral fellowship and a Proctor Honorific Fellowship from Princeton University. S.M.B. and M.D.W. thank S. Gross, L. Satterwhite, and K. Visscher for helpful discussions and advice, and K. Neuman for comments on an early draft of the manuscript. A movie of the tether-particle assay can be viewed at www.rose.brandeis.edu/users/gelles/ stall/