Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis

Journal of Molecular Medicine

Volumn 79, Issue 1, 2001, Pages 48-56

  Pecqueur, Claire ^a   Couplan, Elodie ^a   Bouillaud, Frédéric ^a   Ricquier, Daniel ^a  

^a CNRS   (France)

Author keywords

Energy expenditure; Metabolic disease; Mitochondria; Obesity; Thermogenesis

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; OXIDIZING AGENT; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

BROWN ADIPOSE TISSUE; CELL RESPIRATION; COENZYME; ENERGY; HEAT; HUMAN; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REVIEW; SKELETAL MUSCLE; THERMOGENESIS;

CARRIER PROTEINS; ENERGY METABOLISM; HOMEOSTASIS; HUMANS; ION CHANNELS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PORTRAITS; PROTEINS; RESEARCH PERSONNEL; THERMOGENESIS;

EID: 0035091326     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090000150     Document Type: Review

References (57)

1. Does a thermogenic defect play a role in the pathogenesis of human obesity?
2. Reduced rate of energy expenditure as a risk factor for body-weight gain
3. Energy expenditure and intake in infants born to lean and overweight mothers
4. Changes in energy expenditure resulting from altered body weight
5. A role for brown adipose tissue in diet-induced thermogenesis
6. Brown fat: An energy dissipating tissue
7. Brown adipose tissue. More than an effector of thermogenesis?
8. Brown adipose tissue
9. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
10. Thermogenic mechanisms in brown fat
11. Uncoupling-protein-2: A novel gene linked to obesity and hyperinsulinemia
12. The biochemistry of an inefficient tissue: Brown adipose tissue
13. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
14. The Bcl I polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5′-flanking region
15. Association of -3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women
16. Hyperthyroidism and mitochondrial uncoupling
17. The causes and functions of mitochondrial proton leak
18. Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis
19. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
20. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
21. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
22. Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle
23. A plant cold-induced uncoupling protein
24. AtPUMP: An Arabidopsis gene encoding a plant uncoupling mitochondrial protein
25. Identification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii
26. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast
27. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
28. Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells
29. Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system
30. Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
31. Development of infrared imaging to measure thermogenesis in cell culture: Thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists
32. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
33. Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice
34. Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene
35. Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat Chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) Type 2 diabetic rat
36. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
37. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians
38. Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation
39. A genetic variation in the 5′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity
40. The uncoupling proteins, a review
41. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans
42. Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
43. Role of UCP homologues in skeletal muscles and brown adipose tissue: Mediators of thermogenesis or regulators of lipids as fuel substrate?
44. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
45. Uncoupling: New approaches to an old problem of bioenergetics
46. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
47. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
48. Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating rat liver
49. Transcriptional activation of the Human ucp1 gene in a rodent cell line: Synergism of retinoids, isoproterenol and thiazolidinedione is mediated by a multipartite response element
50. Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2
51. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
52. The association between A55 V variant in UCP2 gene and body fat distribution, serum lipid profile in Chinese
53. Association between a marker in the UCP-2/UCP-3 gene cluster and genetic susceptibility to anorexia nervosa
54. Increase in uncoupling protein-2 mRNA expression by BRL49653 and bromopalmitate in human adipocytes
55. Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue
56. Regulation of UCP2 and UCP3 by muscle disease and physical activity in tetraplegic subjects
57. Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis