Transgenic animals in integrative biology: Approaches and interpretations of outcome

Journal of Applied Physiology

Volumn 88, Issue 3, 2000, Pages 1119-1126

  Williams, R Sanders ^a   Wagner, Peter D ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiovascular physiology; Conditional gene knockout; Gene knockout; Homologous recombination; Respiratory physiology; Transgenic mice

Indexed keywords

CARDIOVASCULAR FUNCTION; EXPERIMENTAL ANIMAL; GENETIC MANIPULATION; KNOCKOUT GENE; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; RESPIRATORY FUNCTION; REVIEW; TECHNIQUE; TECHNOLOGY; TRANSGENIC ANIMAL; TRANSGENIC MOUSE;

EID: 0034055760     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.3.1119     Document Type: Review

References (23)

1. Bermingham. J. R., Jr., S. S. Scherer, S. O'Connell, E. Arroyo, K. A. Kalla, F. L. Powell, and M. G. Rosenfeld. Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration. Genes Dev. 10: 1751-1762, 1996.
2. Braun, T., M. A. Rudnicki, H. H. Arnold, and R. Jaenisch. Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death. Cell 71: 369-382, 1992.
3. Ferrara, N., K. Carver-Moore, H. Chen, M. Dowd, L. Lu, K. S. O'Shea, L. Powell-Braxton, K. J. Hillan, and M. W. Moore. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439-442, 1996.
4. Garry, D. J., G. A. Ordway, J. N. Lorenz, N. B. Radford, E. R. Chin, R. W. Grange, R. Bassel-Duby, and R. S. Williams. Mice without myoglobin. Nature 395: 905-908, 1998.
5. Hammer, R. E., S. D. Maika, J. A. Richardson, J. P. Tang, and J. D. Taurog. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β 2m: an animal model of HLA-B27-associated human disorders. Cell 63: 1099-1112, 1990.
6. Huang, P. L., Z. Huang, H. Mashimo, K. D. Bloch, M. A. Moskowitz, J. A. Bevan, and M. C. Fishman. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377: 239-242, 1995.
7. 2 homeostasis by hypoxia-inducible factor 1 α. Genes Dev. 12: 149-162, 1998.
8. Kurihara, Y., H. Kurihara, H. Suzuki, T. Kodama, K. Maemura, R. Nagai, H. Oda, T. Kuwaki, W. H. Cao, N. Kamada, K. Jishage, Y. Ouchi, S. Azuma, Y. Toyoda, T. Ishikawa, M. Kumada, and Y. Yazaki. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 368: 703-710, 1994.
9. Marth, J. D. Recent advances in gene mutagenesis by site-directed recombination. J. Clin. Invest. 97: 1999-2002, 1996.
10. Megeney, L. A., B. Kablar, K. Garrett, J. E. Anderson, and M. A. Rudnicki. MyoD is required for myogenic stem cell function in adult skeletal muscle. Genes Dev. 10: 1173-1183, 1996.
11. Minamisawa, S., M. Hoshijima, G. Chu, C. A. Ward, K. Frank, Y. Gu, M. E. Martone, Y. Wang, J. Ross, Jr., E. G. Kranias, W. R. Giles, and K. R. Chien. Chronic phospholambansarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99: 313-322, 1999.
12. Mullins, J. J., J. Peters, and D. Ganten. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 344: 541-544, 1990.
13. Olson, E. N., H. H. Arnold, P. W. Rigby, and B. J. Wold. Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell 85: 1-4, 1996.
14. Ordahl, C. P., and B. A. Williams. Knowing chops from chuck: roasting myoD redundancy. Bioessays 20: 357-362, 1998.
15. Rajewsky, K., H. Gu, R. Kuhn, U. A. Betz, W. Muller, J. Roes, and F. Schwenk. Conditional gene targeting. J. Clin. Invest. 98: 600-603, 1996.
16. Rockman, H.A., K. R. Chien, D. J. Choi, G. Iaccarino, J. J. Hunter, J. Ross, Jr., R. J. Lefkowitz, and W. J. Koch. Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc. Natl. Acad. Sci. USA 95: 7000-70005, 1998.
17. Rudnicki, M. A., T. Braun, S. Hinuma, and R. Jaenisch. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell 71: 383-390, 1992.
18. Rudnicki, M. A., P. N. Schnegelsberg, R. H. Stead, T. Braun, H. H. Arnold, and R. Jaenisch. MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75: 1351-1359, 1993.
19. Semenza, G. L., F. Agani, N. Iyer, B. H. Jiang, S. Leung, C. Wiener, and A. Yu. Hypoxia-inducible factor 1: from molecular biology to cardiopulmonary physiology. Chest 114: 40S-45S, 1998.
20. Subramaniam, A., W. K. Jones, J. Gulick, S. Wert, J. Neumann, and J. Robbins. Tissue-specific regulation of the α-myosin heavy chain gene promoter in transgenic mice. J. Biol. Chem. 266: 24613-24620, 1991.
21. Tian, H., R. E. Hammer, A. M. Matsumoto, D. W. Russell, and S. L. McKnight. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 12: 3320-3324, 1998.
22. Yu, A. Y., L. A. Shimoda, N. V. Iyer, D. L. Huso, X. Sun, R. McWilliams, T. Beaty, J. S. Sham, C. M. Wiener, J. T. Sylvester, and G. L. Semenza. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. J. Clin. Invest. 103: 691-696, 1999.
23. Yu, Z., C. S. Redfern, and G. I. Fishman. Conditional transgene expression in the heart. Circ. Res. 79: 691-697, 1996.