BCL-6 regulates chemokine gene transcription in macrophages

Nature Immunology

Volumn 1, Issue 3, 2000, Pages 214-220

  Toney, Lisa M ^a,b   Cattoretti, Giorgio ^c   Graf, Jennifer A ^a,b   Merghoub, Taha ^d   Pandolfi, Pier Paolo ^d   Dalla Favera, Riccardo ^c   Ye, B Hilda ^e   Dent, Alexander L ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WALTHER CANCER INSTITUTE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d Department of Obstetrics Gynecology   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CCL6 PROTEIN, MOUSE; CHEMOKINE; CYTOKINE; DNA BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; ONCOPROTEIN; PROTEIN BCL 6; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GERMINAL CENTER; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; TH2 CELL;

ANIMALS; CHEMOKINE CCL2; CHEMOKINES; CHEMOKINES, CC; CYTOKINES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GERMINAL CENTER; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTE CHEMOATTRACTANT PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; TH2 CELLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034278508     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/79749     Document Type: Article

References (38)

1. Dalla-Favera, R. et al. Identification of genetic lesions associated with diffuse large-cell lymphoma. Ann. Oncol. 5, 55-60 (1994).
2. Bastard, C. et al. LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 83, 2423-2427 (1994).
3. Lo Coco, F. et al. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 83, 1757-1759 (1994).
4. Staudt, L. M., Dent, A. L., Shaffer, A. L. & Yu, X. Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6. Int. Rev. Immunol. 18, 381 (1999).
5. Kerckaert, J. P. et al. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nature Genet. 5, 66-70 (1993).
6. Ye, B. H. et al. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large- cell lymphoma. Science 262, 747-750 (1993).
7. Seyfert, V. L., Allman, D., He, Y. & Staudt, L. M. Transcriptional repression by the proto-oncogene BCL-6. Oncogene 12, 2331-2342 (1996).
8. Deweindt, C. et al. The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth Differ. 6, 1495-1503 (1995).
9. Chang, C. C., Ye, B. H., Chaganti, R. S. & Dalla-Favera, R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl Acad. Sci. USA 93, 6947-6952 (1996).
10. Ye, B. H. et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2- type inflammation. Nature Genet. 16, 161-170 (1997).
11. Dent, A. L., Shaffer, A. L., Yu, X., Allman, D. & Staudt, L. M. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276, 589-592 (1997).
12. Dent, A. L., Hu-Li, J., Paul, W. E. & Staudt, L. S. T helper type 2 inflammatory disease in the absence of IL-4 and STAT6. Proc. Natl Acad. Sci. USA 95, 13823-13828 (1998).
13. Baggiolini, M. Chemokines and leukocyte traffic. Nature 392, 565-568 (1998).
14. Rollins, B. J. Chemokines. Blood 90, 909-928 (1997).
15. Allman, D. et al. BCL-6 expression during B-cell activation. Blood 87, 5257-5268 (1996).
16. Cattoretti, G. et al. BCL-6 protein is expressed in germinal-center B cells. Blood 86, 45-53 (1995).
17. Onizuka, T. et al. BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 86, 28-37 (1995).
18. Yamochi, T. et al. Regulation of BCL-6 gene expression in human myeloid/monocytoid leukemic cells. Leukemia 11, 694-700 (1997).
19. Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877 (1992).
20. Mombaerts, P. et al. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360, 225-231 (1992). [Published Erratum appears in Nature 360, 491 (1992).]
21. Kitamura, D., Roes, J., Kuhn, R. & Rajewsky, K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobglin mu chain gene. Nature 350, 423-426 (1991).
22. Fukuda, T. et al. Disruption of the Bcl6 gene results in an impaired germinal center formation. J. Exp. Med. 186, 439-448 (1997).
23. Schook, L. B., Albrecht, H., Gallay, P. & Jongeneel, C. V. Cytokine regulation of TNF-α mRNA and protein production by unprimed macrophages from C57B1/6 and NZW mice. J. Leuk. Biol. 56, 514-520 (1994).
24. Biswas, P. et al. Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U937 cell line. Blood 91, 258-265 (1998).
25. Zhang, S., Lukacs, N. W., Lawless, V. A., Kunkel, S. L. & Kaplan, M. H. Cutting edge: differential expression of chemokines in Th1 and Th2 cells is dependent on stat6 but not stat4. J. Immunol. 165, 10-14 (2000).
26. Li, L. et al. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J. Immunol. 162, 2477-2487 (1999).
27. Huynh, K. D., Fischle, W., Verdin, E. & Bardwell, V. J. BCoR, a novel compressor involved in BCL-6 repression. Genes Dev. 14, 1810-1823 (2000).
28. H2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 404, 407-411 (2000).
29. Lukacs, N. W. et al. C-C chemokines differentially alter interleukin-4 production from lymphocytes. Am J Pathol 150, 1861-1868 (1997).
30. Karpus, W. J. et al. Differential CC chemokine-induced enhancement of T helper cell cytokine production. J. Immunol. 158, 4129-4136 (1997).
31. Karpus, W. J. & Kennedy, K. J. M1P-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation. J. Leuk. Biol. 62, 681-687 (1997).
32. Braun, M. C., Lahey, E. & Kehall, B. L. Selective suppression of IL-12 production by chemoattractants. J. Immunol. 164, 3009-3017 (2000).
33. Kapsenberg, M. L., Hilkens, C. M., Wierenga, E. A. & Kalinski, P. The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy. Clin. Exp. Aller. 29, 33-36 (1999).
34. Abbas, A. K., Murphy, K. M. & Sher, A. Functional diversity of helper T lymphocytes. Nature 383, 787-793 (1996).
35. Harris, M. B. et al. Transcriptional Repression of State-Dependent Interleukin-4-Induced Genes by BCL-6: Specific Regulation of lepsilon Transcription and Immunoglobulin E Switching. Mol. Cell Biol. 19, 7264-7275 (1999).
36. Friend, D. S. et al. Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype. J. Cell Biol. 135, 279-290 (1996).
37. Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning: A Laboratory Manual. (Cold Spring Harbor Laboratory, New York, 1989).
38. Schreiber, E., Matthias, P., Muller, M. M. & Schaffner, W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17, 6419 (1989).