Tetraspanins

Cellular and Molecular Life Sciences

Volumn 58, Issue 9, 2001, Pages 1189-1205

  Boucheix, C ^a   Rubinstein, E ^a  

^a HÔPITAL PAUL BROUSSE   (France)

Author keywords

Cancer; Cell migration; Fusion; Integrin; Reproduction; Tetraspanin

Indexed keywords

TETRASPANIN;

CELL MIGRATION; CELL SURFACE; CYTOLOGY; KNOCKOUT MOUSE; LEUKOCYTE; MEMBRANE STRUCTURE; NONHUMAN; REVIEW; SEQUENCE HOMOLOGY;

EID: 0034849902     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000933     Document Type: Review

References (189)

1. The ins and outs of the transmembrane 4 superfamily
2. The tetraspanin superfamily: Molecular facilitators
3. CD81 extracellular domain 3D structure: Insight into the tetraspanin superfamily structural motifs
4. Molecular cloning of the CD9 antigen. A new family of cell surface proteins
5. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins
6. The tetraspanin superfamily in insects
7. Comparison of the cloned genes of the 26- and 28-kilodalton glutathione S-transferases of Schistosoma japonicum and Schistosoma mansoni
8. A new transmembrane 4 superfamily molecule in the nematode, Caenorhabditis elegans
9. Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens
10. Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily
11. SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins
12. Sequences and expression of six new members of the tetraspanin/TM4SF family
13. Sequence and expression of seven new tetraspans
14. Formation of asymmetric unit membrane during urothelial differentiation
15. Retinitis pigmentosa: Defined from a molecular point of view
16. The L6 membrane proteins - A new four-transmembrane superfamily
17. Sarcospan, the 25-kDa transmembrane component of the dystrophin- glycoprotein complex
18. Antibodies and molecules of the 5th International Workshop of Leukocyte Differentiation antigens
19. Tetraspans
20. PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function
21. A new set of monoclonal antibodies against acute lymphoblastic leukemia
22. Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: Comparison with CD9, CD63 and alpha5beta1 integrin
23. MRP-1/CD9 and KAI1/CD82 expression in normal and various cancer tissues
24. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD 151/alpha3beta1, CD 151/alpha6beta1) under conditions disrupting tetraspan interactions
25. Identity of Pltgp40 and lysomal integral membrane protein-CD63
26. CD63/Pltgp40: A platelet activation antigen identical to the stage- specific, melanoma-associated antigen ME491
27. CD63 is a component of Weibel-Palade bodies of human endothelial cells
28. Membrane surface antigen expression on neutrophils: A reappraisal of the use of surface markers for neutrophil activation
29. Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion
30. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
31. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM and -DO molecules
32. B lymphocytes secrete antigen-presenting vesicles
33. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73
34. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity
35. Signaling through the EBV/C3d receptor (CR2, CD21) in human B lymphocytes: Activation of phosphatidylinositol 3-kinase via a CD 19- independent pathway
36. CD19 as a membrane-anchored adaptor protein of B lymphocytes: Costimulation of lipid and protein kinases by recruitment of Vav
37. The CD19/CR2/TAPA-1 complex of B lymphocytes: Linking natural to acquired immunity
38. Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity
39. The membrane protein CD9/DRAP27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor
40. Possible role of co-expression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth
41. The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation
42. Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins
43. CD9 antigen is an accessory subunit of the VLA integrin complexes
44. Specific association of CD63 with the VLA-3 and VLA-6 integrins
45. CD9, CD63, CD81 and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins
46. Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins)
47. Ligation of TAPA-1 (CD81) or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4+ T cells
48. Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82
49. The CD19/CR2/TAPA-1 complex of B lymphocytes: Linking natural to acquired immunity
50. The CD19/CD21 signal transduction complex of B lymphocytes
51. Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes
52. Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4- kinase, and may regulate cell migration
53. The major CD9 and CD81 molecular partner: Identification and characterization of the complexes
54. FPRP: A major, highly stoichiometric, highly specific CD81 and CD9-associated protein
55. The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13
56. Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes
57. Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63 and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)
58. CD19 is linked to the integrin-associated tetraspans CD9, CD81 and CD82
59. Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151
60. Functional analysis of four tetraspans, CD9, CD53, CD81 and CD82, suggests a common role in costimulation, cell adhesion and migration: Only CD9 upregulates HB-EGF activity
61. Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity
62. Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell-cell contact sites
63. The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes
64. Cloning of the cDNA for a novel photoreceptor membrane protein (rom-1) identifies a disk rim protein family implicated in human retinopathies
65. Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane- domained proteins in differentiated urothelial cells
66. CD9 and megakaryocytic differentiation
67. CD9 antigen mRNA is induced by hypertonicity in two renal epithelial cell lines
68. CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells
69. Anti-CD9 monoclonal antibodies induce homotypic adhesion of pre- B cell lines by a novel mechanism
70. Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility
71. Platelet activation by CD9 monoclonal antibodies is mediated by the Fc gamma II receptor
72. Anti-platelet antibody interactions with Fc gamma receptor
73. Functional significance of CD9 association with beta 1 integrins in human epidermal keratinocytes
74. Differential display cloning identifies motility-related protein (MRP1/CD9) as highly expressed in primary compared to metastatic human colon carcinoma cells
75. Regulation of tumor cell motility and migration by CD63 in a human melanoma cell line
76. Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with α3β1 integrin localized at endothelial lateral junctions
77. CD9 plays a role in Schwann cell migration in vitro
78. Function of alpha3 beta1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2)
79. Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA
80. Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene
81. Ectopic expression of human and feline CD9 in a human B cell line confers beta 1 integrin-dependent motility on fibronectin and laminin substrates and enhanced tyrosine phosphorylation
82. Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis
83. Characterization of integrin-tetraspanin adhesion complexes: Role of tetraspanins in integrin signaling
84. Tetraspanins are localized at motility-related structures and involved in normal human keratinocyte wound healing migration
85. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81) and phosphatidylinositol 4-kinase
86. Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1
87. CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells
88. Anti-TAPA-1 antibodies induce protein tyrosine phosphorylation that is prevented by increasing intracellular thiol levels
89. CD81 expressed on human thymocytes mediates integrin activation and interleukin 2-dependent proliferation
90. The 4F9 antigen is a member of the tetra spans transmembrane protein family and functions as an accessory molecule in T cell activation and adhesion
91. Signaling through the tetraspanin CD82 triggers its association with the cytoskeleton leading to sustained morphological changes and T cell activation
92. A role for CD9 molecules in T cell activation
93. Synergy between CD28 and CD9 costimulation for naive T-cell activation
94. CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis
95. CD81 and CD28 costimulate T cells through distinct pathways
96. C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells
97. Interaction of CD82 tetraspanin proteins with HTLV-1 envelope glycoproteins inhibits cell-to-cell fusion and virus transmission
98. FIV infection of the domestic cat: An animal model for AIDS
99. CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus
100. Inhibition of feline immunodeficiency virus infection by CD9 antibody operates after virus entry and is independent of virus tropism
101. Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance
102. Severely reduced female fertility in CD9-deficient mice
103. Requirement of CD9 on the egg plasma membrane for fertilization
104. The gamete fusion process is defective in eggs of Cd9-deficient mice
105. Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: Implications for murine fertilization
106. Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent
107. Negative regulation of Fc epsilon RI-mediated degranulation by CD81
108. Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81
109. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice
110. CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses
111. Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice
112. Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions
113. Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression
114. Motility related protein 1 (MRP-1/CD9) expression: Inverse correlation with metastases in breast cancer
115. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2
116. KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases
117. KAI1, a new metastasis suppressor gene, is reduced in metastatic hepatocellular carcinoma
118. Motility-related protein-1 (MRP-1/CD9) reduction as a factor of poor prognosis in breast cancer
119. Reduced motility related protein-1 (MRP-1/CD9) gene expression as a factor of poor prognosis in non-small cell lung cancer
120. Correlation of KAI1/CD82 gene expression with good prognosis in patients with non-small cell lung cancer
121. Motility related protein 1 (MRP1/CD9) expression in colon cancer
122. Reduced expression of the metastasis suppressor gene KAI1 in advanced colon cancer and its metastases
123. Correlation of reduction in MRP-1/CD9 and KAI1/CD82 expression with recurrences in breast cancer patients
124. Transmembrane 4 superfamily as a prognostic factor in pancreatic cancer
125. Loss of KAI1 expression in the progression of colorectal cancer
126. A novel molecular staging protocol for non-small cell lung cancer
127. Novel staging protocol for non-small-cell lung cancers according to MRP-1/CD9 and KAI1/CD82 gene expression
128. Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491)
129. Association between the rat homologue of CO-029, a metastasis- associated tetraspanin molecule and consumption coagulopathy
130. Association of TM4SF proteins with integrins: Relevance to cancer
131. Integrins and GTPases in tumour cell growth, motility and invasion
132. Extracellular matrix signaling: Integration of form and function in normal and malignant cells
133. The biology of cell locomotion within three-dimensional extracellular matrix
134. Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL
135. An antibody to the tetraspan membrane protein CD9 promotes neurite formation in a partially alpha3beta1 integrin-dependent manner
136. Function of tetraspan proteins in the myelin sheath
137. Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha3 beta1 integrin, and selectively contribute to alpha3beta11-dependent neurite outgrowth
138. Up-regulation of CD81 (target of the antiproliferative antibody; TAPA) by reactive microglia and astrocytes after spinal cord injury in the rat
139. Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures
140. CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the alpha 6/beta 1 integrin and the neural adhesion molecule L1
141. A neural tetraspanin, encoded by late bloomer, that facilitates synapse formation
142. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation
143. Development and degeneration of retina in rds mutant mice: Photoreceptor abnormalities in the heterozygotes
144. Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis
145. Is CD81 the key to hepatitis C virus entry?
146. Binding of hepatitis C virus to CD81
147. Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection
148. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81
149. Enhanced CD9 expression in the mouse and human brains infected with transmissible spongiform encephalopathies
150. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans
151. The tetraspanin CD9 is associated with VLA integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization
152. NAG-2 a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins
153. SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily, associates preferentially with alpha 5 beta 1 integrin and regulates adhesion of human T cell leukemia virus type 1-infected T cells to fibronectin
154. The platelet antigens CD9, CD42 and integrin alpha IIb beta IIIa can be topographically associated and transduce functionally similar signals
155. Evidence that monoclonal antibodies against CD9 antigen induce specific association between CD9 and the platelet glycoprotein IIb-IIIa complex
156. Analysis of the tetraspanin CD9-integrin alphaIIbbeta3 (GPIIb-IIIa) complex in platelet membranes and transfected cells
157. A CD9, IIb3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by IIb3 conformational states
158. CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils
159. Overexpression of CD82 on human T cells enhances LFA-1/ICAM-1-mediated cell-cell adhesion: Functional association between CD82 and LFA-1 in T cell activation
160. Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY
161. The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes
162. Association of a tetraspanin CD9 with CD5 on the T cell surface: Role of particular transmembrane domains in the association
163. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules
164. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen
165. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line
166. Human tumor cell membrane glycoprotein associated with protein kinase activity
167. Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity
168. Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoiositide 4-kinase
169. Platelet activation induced by a murine monoclonal antibody directed against a novel tetra-span antigen
170. CD82, tetra-span-transmembrane protein, is a regulated transducing molecule on U937 monocytic cell line
171. Expression of the neuroglandular antigen and analogues in melanoma. CD9 expression appears inversely related to metastatic potential of melanoma
172. Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss
173. Motility-related protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma
174. Expression of the prostate cancer metastasis suppressor gene KAI1 in primary prostate cancers: A biphasic relationship with tumour grade
175. KAI1 gene expression in hepatocellular carcinoma and its relationship with intrahepatic metastases
176. KAI1 protein is down-regulated during the progression of human breast cancer
177. Relationship between expression of the KAI1 metastasis suppressor and other markers of advanced bladder cancer
178. Reduced invasive and metastatic potentials of KAI1-transfected melanoma cells
179. KAI1, a putative marker for metastatic potential in human breast cancer
180. Combining evolutionary information and neural networks to predict protein secondary structure
181. Organization of the human CD9 gene
182. Characterisation of mouse CD37: cDNA and genomic cloning
183. Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): Evidence that the transmembrane 4 superfamily arose by gene duplication
184. Genomic structure of the human CD53 gene
185. Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5′-flanking regulatory sequences
186. Genomic organization and chromosomal localization of the TAPA-1 gene
187. Genomic organization of the human KAI1 metastasis-suppressor gene
188. Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: Complementary DNA, genomic structure, and expression
189. Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms