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Volumn 271, Issue 5257, 1996, Pages 1867-1870

A neural tetraspanin, encoded by late bloomer, that facilitates synapse formation

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; COMPLEMENTARY DNA;

EID: 0029988151     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5257.1867     Document Type: Article
Times cited : (156)

References (51)
  • 1
    • 0027351577 scopus 로고    scopus 로고
    • C.S. Goodman and C. J Shatz, Cell 72, 77 (1993); C. S. Goodman, Annu. Rev. Neurosci., in press.
    • (1993) Cell , vol.72 , pp. 77
    • Goodman, C.S.1    Shatz, C.J.2
  • 5
    • 13344265066 scopus 로고    scopus 로고
    • in preparation
    • A detailed description of the methods is available from the authors or at http://fruitfly.berkeley.edu (C. C. Kopczynski, T. Serano, G R Rubin, C. S. Goodman, in preparation).
    • Kopczynski, C.C.1    Serano, T.2    Rubin, G.R.3    Goodman, C.S.4
  • 6
    • 13344258133 scopus 로고    scopus 로고
    • note
    • LBL appears to be expressed by all motoneurons whose axons exit in the two major motor nerves (the intersegmental and segmental nerves) and innervate somatic body wall muscles; LBL is probably not expressed by motor axons that exit other nerves and innervate visceral and respiratory muscles.
  • 7
    • 13344287835 scopus 로고    scopus 로고
    • note
    • The small amount of lbl expression in peripheral sensory neurons begins at stage 14 and disappears by stage early 17.
  • 8
    • 13344268378 scopus 로고    scopus 로고
    • note
    • Y13 embryos
  • 9
    • 13344252612 scopus 로고    scopus 로고
    • note
    • A 1.2-kb insert in cDNA clone p3B6 6 was subcloned as six smaller fragments into Bluescript SK+ (Stratagene). Double-stranded template DNA was sequenced on both strands by means of the Autoread sequencing kit (Pharmacia) and ALE automated sequencer (Pharmacia).
  • 10
    • 0025183708 scopus 로고
    • DNA and protein databases were searched with the program BLAST [S. F. Altschul et al., J. Mol. Biol. 215, 403 (1990)].
    • (1990) J. Mol. Biol. , vol.215 , pp. 403
    • Altschul, S.F.1
  • 11
    • 0025826166 scopus 로고
    • V. Horejsi and C. Vlcok, FEBS Lett. 288, 1 (1991), M. L. Gil et al., J. Immunol. 148, 2826 (1992); T. Imai et al., ibid. 149, 2879 (1992); M. G. Tomlinson, A. F. Williams, M. D. Wright, Eur. J. Immunol. 23, 136 (1993).
    • (1991) FEBS Lett. , vol.288 , pp. 1
    • Horejsi, V.1    Vlcok, C.2
  • 12
    • 0026524358 scopus 로고
    • V. Horejsi and C. Vlcok, FEBS Lett. 288, 1 (1991), M. L. Gil et al., J. Immunol. 148, 2826 (1992); T. Imai et al., ibid. 149, 2879 (1992); M. G. Tomlinson, A. F. Williams, M. D. Wright, Eur. J. Immunol. 23, 136 (1993).
    • (1992) J. Immunol. , vol.148 , pp. 2826
    • Gil, M.L.1
  • 13
    • 0026703106 scopus 로고
    • V. Horejsi and C. Vlcok, FEBS Lett. 288, 1 (1991), M. L. Gil et al., J. Immunol. 148, 2826 (1992); T. Imai et al., ibid. 149, 2879 (1992); M. G. Tomlinson, A. F. Williams, M. D. Wright, Eur. J. Immunol. 23, 136 (1993).
    • (1992) J. Immunol. , vol.149 , pp. 2879
    • Imai, T.1
  • 14
    • 0027446527 scopus 로고
    • V. Horejsi and C. Vlcok, FEBS Lett. 288, 1 (1991), M. L. Gil et al., J. Immunol. 148, 2826 (1992); T. Imai et al., ibid. 149, 2879 (1992); M. G. Tomlinson, A. F. Williams, M. D. Wright, Eur. J. Immunol. 23, 136 (1993).
    • (1993) Eur. J. Immunol. , vol.23 , pp. 136
    • Tomlinson, M.G.1    Williams, A.F.2    Wright, M.D.3
  • 15
    • 13344255874 scopus 로고    scopus 로고
    • note
    • CD37 and CD53, two tetraspanins most closely related to LBL, share 29% amino acid identity with one another but only 19% and 16% amino acid identity, respectively, with LBL. Sequence similarity among tetraspanins is highest in and between TM2 and TM3, in this region, CD37 and CD53 share 39% amino acid identity, whereas LBL shares 27% amino acid identity with CD37 and 25% identity with CD53.
  • 17
    • 0027232876 scopus 로고
    • The 1D4 mAb recognizes Fasciclin II, a marker for motor axons, growth cones, and terminal arbors [D. Van Vactor et al., Cell 73, 1137 (1993)].
    • (1993) Cell , vol.73 , pp. 1137
    • Van Vactor, D.1
  • 19
    • 13344291097 scopus 로고    scopus 로고
    • note
    • 1118) embryos, the RP3 terminal arbor was absent in only 12% of stage late 16 hemisegments (n = 128) and in only 2% of stage early 17 hemisegments (n = 118). Ectopic TN arborizations were observed in 11 % of stage late 16 control embryos (n = 114) and in 3% of stage early 17 control embryos (n = 127).
  • 20
    • 0027207209 scopus 로고
    • This tendency of the TN to sprout onto muscles 6 and 7 in the absence of a functional RP3 synapse has been observed previously [H Keshishian et al., J. Neurobiol. 24, 757 (1993); J. Jarecki and H. Keshishian, J. Neurosci. 15, 8177 (1995).
    • (1993) J. Neurobiol. , vol.24 , pp. 757
    • Keshishian, H.1
  • 21
    • 0029590041 scopus 로고
    • This tendency of the TN to sprout onto muscles 6 and 7 in the absence of a functional RP3 synapse has been observed previously [H Keshishian et al., J. Neurobiol. 24, 757 (1993); J. Jarecki and H. Keshishian, J. Neurosci. 15, 8177 (1995).
    • (1995) J. Neurosci. , vol.15 , pp. 8177
    • Jarecki, J.1    Keshishian, H.2
  • 22
    • 0027249801 scopus 로고
    • First-instar larvae were selected O to 5 hours after hatching and dissected Synaptic boutons were visualized with a polyclonal antibody to synaptotagmin [J. T. Littleton et al., Development 118, 1077 (1993)]. Boutons were counted in segments A2 to A5. The mean numbers of boutons (±SD) were 14.5 ± 3.5 for the control (Canton S) (n = 37) and 14.3 ± 3 4 for the lbl mutant (n = 67).
    • (1993) Development , vol.118 , pp. 1077
    • Littleton, J.T.1
  • 24
    • 0025843536 scopus 로고
    • J. B. Thomas, M. J. Bastiani, M. Bate, C. S Goodman, Nature 310, 203 (1984); H. Sink and P. M. Whitington, Development 112, 307 (1991).
    • (1991) Development , vol.112 , pp. 307
    • Sink, H.1    Whitington, P.M.2
  • 25
    • 0029112968 scopus 로고
    • T Imai, M. Kakizaki, M. Nishimura, O. Yoshie, J. Immunol. 155, 1229 (1995); G. M. Bell, W. E Seaman, E. C. Neimi, J. B. Imbolden, J. Exp. Med. 175, 527 (1992); S Kitani, E. Berentstein, S. Mergenhagen, P. Tempst, R. P. Siraganian, J. Biol. Chem. 266, 1903 (1991); J. J. Roberts, S. E. Rodgers, J Drury, L K. Ashman, J. V. Lloyd, Brit. J. Haematol 89, 853 (1995); E. Rubinstein, F Le Naour, M. Billard, M. Prenant, C. Boucheix, Eur. J. Immunol. 24, 3005 (1994); F. Berditchevski, G. Bazzoni, M. E. Hemler, J Biol. Chem. 270, 17784 (1995)
    • (1995) J. Immunol. , vol.155 , pp. 1229
    • Imai, T.1    Kakizaki, M.2    Nishimura, M.3    Yoshie, O.4
  • 26
    • 0026585492 scopus 로고
    • T Imai, M. Kakizaki, M. Nishimura, O. Yoshie, J. Immunol. 155, 1229 (1995); G. M. Bell, W. E Seaman, E. C. Neimi, J. B. Imbolden, J. Exp. Med. 175, 527 (1992); S Kitani, E. Berentstein, S. Mergenhagen, P. Tempst, R. P. Siraganian, J. Biol. Chem. 266, 1903 (1991); J. J. Roberts, S. E. Rodgers, J Drury, L K. Ashman, J. V. Lloyd, Brit. J. Haematol 89, 853 (1995); E. Rubinstein, F Le Naour, M. Billard, M. Prenant, C. Boucheix, Eur. J. Immunol. 24, 3005 (1994); F. Berditchevski, G. Bazzoni, M. E. Hemler, J Biol. Chem. 270, 17784 (1995)
    • (1992) J. Exp. Med. , vol.175 , pp. 527
    • Bell, G.M.1    Seaman, W.E.2    Neimi, E.C.3    Imbolden, J.B.4
  • 27
    • 0025967122 scopus 로고
    • T Imai, M. Kakizaki, M. Nishimura, O. Yoshie, J. Immunol. 155, 1229 (1995); G. M. Bell, W. E Seaman, E. C. Neimi, J. B. Imbolden, J. Exp. Med. 175, 527 (1992); S Kitani, E. Berentstein, S. Mergenhagen, P. Tempst, R. P. Siraganian, J. Biol. Chem. 266, 1903 (1991); J. J. Roberts, S. E. Rodgers, J Drury, L K. Ashman, J. V. Lloyd, Brit. J. Haematol 89, 853 (1995); E. Rubinstein, F Le Naour, M. Billard, M. Prenant, C. Boucheix, Eur. J. Immunol. 24, 3005 (1994); F. Berditchevski, G. Bazzoni, M. E. Hemler, J Biol. Chem. 270, 17784 (1995)
    • (1991) J. Biol. Chem. , vol.266 , pp. 1903
    • Kitani, S.1    Berentstein, E.2    Mergenhagen, S.3    Tempst, P.4    Siraganian, R.P.5
  • 28
    • 0028911119 scopus 로고
    • T Imai, M. Kakizaki, M. Nishimura, O. Yoshie, J. Immunol. 155, 1229 (1995); G. M. Bell, W. E Seaman, E. C. Neimi, J. B. Imbolden, J. Exp. Med. 175, 527 (1992); S Kitani, E. Berentstein, S. Mergenhagen, P. Tempst, R. P. Siraganian, J. Biol. Chem. 266, 1903 (1991); J. J. Roberts, S. E. Rodgers, J Drury, L K. Ashman, J. V. Lloyd, Brit. J. Haematol 89, 853 (1995); E. Rubinstein, F Le Naour, M. Billard, M. Prenant, C. Boucheix, Eur. J. Immunol. 24, 3005 (1994); F. Berditchevski, G. Bazzoni, M. E. Hemler, J Biol. Chem. 270, 17784 (1995)
    • (1995) Brit. J. Haematol , vol.89 , pp. 853
    • Roberts, J.J.1    Rodgers, S.E.2    Drury, J.3    Ashman, L.K.4    Lloyd, J.V.5
  • 29
    • 0028561906 scopus 로고
    • T Imai, M. Kakizaki, M. Nishimura, O. Yoshie, J. Immunol. 155, 1229 (1995); G. M. Bell, W. E Seaman, E. C. Neimi, J. B. Imbolden, J. Exp. Med. 175, 527 (1992); S Kitani, E. Berentstein, S. Mergenhagen, P. Tempst, R. P. Siraganian, J. Biol. Chem. 266, 1903 (1991); J. J. Roberts, S. E. Rodgers, J Drury, L K. Ashman, J. V. Lloyd, Brit. J. Haematol 89, 853 (1995); E. Rubinstein, F Le Naour, M. Billard, M. Prenant, C. Boucheix, Eur. J. Immunol. 24, 3005 (1994); F. Berditchevski, G. Bazzoni, M. E. Hemler, J Biol. Chem. 270, 17784 (1995)
    • (1994) Eur. J. Immunol. , vol.24 , pp. 3005
    • Rubinstein, E.1    Le Naour, F.2    Billard, M.3    Prenant, M.4    Boucheix, C.5
  • 30
    • 0029029882 scopus 로고
    • T Imai, M. Kakizaki, M. Nishimura, O. Yoshie, J. Immunol. 155, 1229 (1995); G. M. Bell, W. E Seaman, E. C. Neimi, J. B. Imbolden, J. Exp. Med. 175, 527 (1992); S Kitani, E. Berentstein, S. Mergenhagen, P. Tempst, R. P. Siraganian, J. Biol. Chem. 266, 1903 (1991); J. J. Roberts, S. E. Rodgers, J Drury, L K. Ashman, J. V. Lloyd, Brit. J. Haematol 89, 853 (1995); E. Rubinstein, F Le Naour, M. Billard, M. Prenant, C. Boucheix, Eur. J. Immunol. 24, 3005 (1994); F. Berditchevski, G. Bazzoni, M. E. Hemler, J Biol. Chem. 270, 17784 (1995)
    • (1995) J Biol. Chem. , vol.270 , pp. 17784
    • Berditchevski, F.1    Bazzoni, G.2    Hemler, M.E.3
  • 33
    • 0028295237 scopus 로고
    • L Bosca and P A. Lazo, J. Exp Med 179, 1119 (1994); S. Lebel-Binay, C Lagaudnere, D. Fradelizi, H. Conjeaud, J Leukocyte Biol 57, 956 (1995).
    • (1994) J. Exp Med , vol.179 , pp. 1119
    • Bosca, L.1    Lazo, P.A.2
  • 37
    • 0029048985 scopus 로고
    • J.-T. Dong et al. Science 268, 884 (1995), S. Ikeyama, M. Koyama, M. Yamaoko, R. Sasada, M Miyake, J Exp. Med. 177, 1231 (1993); Z. Si and P. Hershey, Int. J. Cancer 54, 37 (1993)
    • (1995) Science , vol.268 , pp. 884
    • Dong, J.-T.1
  • 39
    • 0027285536 scopus 로고
    • J.-T. Dong et al. Science 268, 884 (1995), S. Ikeyama, M. Koyama, M. Yamaoko, R. Sasada, M Miyake, J Exp. Med. 177, 1231 (1993); Z. Si and P. Hershey, Int. J. Cancer 54, 37 (1993)
    • (1993) Int. J. Cancer , vol.54 , pp. 37
    • Si, Z.1    Hershey, P.2
  • 40
    • 0027249060 scopus 로고    scopus 로고
    • S. Tole and P. H. Patterson, Dev. Dyn. 197, 94 (1993); Z Kaprielian, C Kyung-Ok, M. Hadjiargyrou, P. H Patterson, J Neurosci. 15, 562 (1995); M Hadjiargyrou and P. H. Patterson, ibid., p. 574.
    • (1993) Dev. Dyn. , vol.197 , pp. 94
    • Tole, S.1    Patterson, P.H.2
  • 42
    • 0027249060 scopus 로고    scopus 로고
    • S. Tole and P. H. Patterson, Dev. Dyn. 197, 94 (1993); Z Kaprielian, C Kyung-Ok, M. Hadjiargyrou, P. H Patterson, J Neurosci. 15, 562 (1995); M Hadjiargyrou and P. H. Patterson, ibid., p. 574.
    • J Neurosci. , pp. 574
    • Hadjiargyrou, M.1    Patterson, P.H.2
  • 43
    • 0024511256 scopus 로고
    • B. J. Classon et al., J. Exp Med. 169, 1497 (1989), M Amiot, J. Immunol. 145, 4322 (1990); M. J Metzelaar et al., J. Biol. Chem. 266, 3239 (1991), H. W. Gaugitsch et al., Eur. J. Immunol. 21, 377 (1991 ); N. Emi et al., Immunogenetics 37, 193 (1993), S Szala et al., Proc. Natl. Acad. Sci. U.S.A. 87, 6833 (1990); K. M. Davern, M. D. Wright, V. R. Herrmann, G. F. Mitchell, Mol. Biochem. Parasitol. 48, 67 (1991); S. Fitter, T A. Tetaz, M. C Berndt, L. K Ashman, Blood 86, 1348 (1995).
    • (1989) J. Exp Med. , vol.169 , pp. 1497
    • Classon, B.J.1
  • 44
    • 0025676566 scopus 로고
    • B. J. Classon et al., J. Exp Med. 169, 1497 (1989), M Amiot, J. Immunol. 145, 4322 (1990); M. J Metzelaar et al., J. Biol. Chem. 266, 3239 (1991), H. W. Gaugitsch et al., Eur. J. Immunol. 21, 377 (1991 ); N. Emi et al., Immunogenetics 37, 193 (1993), S Szala et al., Proc. Natl. Acad. Sci. U.S.A. 87, 6833 (1990); K. M. Davern, M. D. Wright, V. R. Herrmann, G. F. Mitchell, Mol. Biochem. Parasitol. 48, 67 (1991); S. Fitter, T A. Tetaz, M. C Berndt, L. K Ashman, Blood 86, 1348 (1995).
    • (1990) J. Immunol. , vol.145 , pp. 4322
    • Amiot, M.1
  • 45
    • 0025819331 scopus 로고
    • B. J. Classon et al., J. Exp Med. 169, 1497 (1989), M Amiot, J. Immunol. 145, 4322 (1990); M. J Metzelaar et al., J. Biol. Chem. 266, 3239 (1991), H. W. Gaugitsch et al., Eur. J. Immunol. 21, 377 (1991 ); N. Emi et al., Immunogenetics 37, 193 (1993), S Szala et al., Proc. Natl. Acad. Sci. U.S.A. 87, 6833 (1990); K. M. Davern, M. D. Wright, V. R. Herrmann, G. F. Mitchell, Mol. Biochem. Parasitol. 48, 67 (1991); S. Fitter, T A. Tetaz, M. C Berndt, L. K Ashman, Blood 86, 1348 (1995).
    • (1991) J. Biol. Chem. , vol.266 , pp. 3239
    • Metzelaar, M.J.1
  • 46
    • 0025976509 scopus 로고
    • B. J. Classon et al., J. Exp Med. 169, 1497 (1989), M Amiot, J. Immunol. 145, 4322 (1990); M. J Metzelaar et al., J. Biol. Chem. 266, 3239 (1991), H. W. Gaugitsch et al., Eur. J. Immunol. 21, 377 (1991 ); N. Emi et al., Immunogenetics 37, 193 (1993), S Szala et al., Proc. Natl. Acad. Sci. U.S.A. 87, 6833 (1990); K. M. Davern, M. D. Wright, V. R. Herrmann, G. F. Mitchell, Mol. Biochem. Parasitol. 48, 67 (1991); S. Fitter, T A. Tetaz, M. C Berndt, L. K Ashman, Blood 86, 1348 (1995).
    • (1991) Eur. J. Immunol. , vol.21 , pp. 377
    • Gaugitsch, H.W.1
  • 47
    • 0027397477 scopus 로고
    • B. J. Classon et al., J. Exp Med. 169, 1497 (1989), M Amiot, J. Immunol. 145, 4322 (1990); M. J Metzelaar et al., J. Biol. Chem. 266, 3239 (1991), H. W. Gaugitsch et al., Eur. J. Immunol. 21, 377 (1991 ); N. Emi et al., Immunogenetics 37, 193 (1993), S Szala et al., Proc. Natl. Acad. Sci. U.S.A. 87, 6833 (1990); K. M. Davern, M. D. Wright, V. R. Herrmann, G. F. Mitchell, Mol. Biochem. Parasitol. 48, 67 (1991); S. Fitter, T A. Tetaz, M. C Berndt, L. K Ashman, Blood 86, 1348 (1995).
    • (1993) Immunogenetics , vol.37 , pp. 193
    • Emi, N.1
  • 48
    • 0025187851 scopus 로고
    • B. J. Classon et al., J. Exp Med. 169, 1497 (1989), M Amiot, J. Immunol. 145, 4322 (1990); M. J Metzelaar et al., J. Biol. Chem. 266, 3239 (1991), H. W. Gaugitsch et al., Eur. J. Immunol. 21, 377 (1991 ); N. Emi et al., Immunogenetics 37, 193 (1993), S Szala et al., Proc. Natl. Acad. Sci. U.S.A. 87, 6833 (1990); K. M. Davern, M. D. Wright, V. R. Herrmann, G. F. Mitchell, Mol. Biochem. Parasitol. 48, 67 (1991); S. Fitter, T A. Tetaz, M. C Berndt, L. K Ashman, Blood 86, 1348 (1995).
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 6833
    • Szala, S.1
  • 49
    • 0025835990 scopus 로고
    • B. J. Classon et al., J. Exp Med. 169, 1497 (1989), M Amiot, J. Immunol. 145, 4322 (1990); M. J Metzelaar et al., J. Biol. Chem. 266, 3239 (1991), H. W. Gaugitsch et al., Eur. J. Immunol. 21, 377 (1991 ); N. Emi et al., Immunogenetics 37, 193 (1993), S Szala et al., Proc. Natl. Acad. Sci. U.S.A. 87, 6833 (1990); K. M. Davern, M. D. Wright, V. R. Herrmann, G. F. Mitchell, Mol. Biochem. Parasitol. 48, 67 (1991); S. Fitter, T A. Tetaz, M. C Berndt, L. K Ashman, Blood 86, 1348 (1995).
    • (1991) Mol. Biochem. Parasitol. , vol.48 , pp. 67
    • Davern, K.M.1    Wright, M.D.2    Herrmann, V.R.3    Mitchell, G.F.4
  • 50
    • 0029091211 scopus 로고
    • B. J. Classon et al., J. Exp Med. 169, 1497 (1989), M Amiot, J. Immunol. 145, 4322 (1990); M. J Metzelaar et al., J. Biol. Chem. 266, 3239 (1991), H. W. Gaugitsch et al., Eur. J. Immunol. 21, 377 (1991 ); N. Emi et al., Immunogenetics 37, 193 (1993), S Szala et al., Proc. Natl. Acad. Sci. U.S.A. 87, 6833 (1990); K. M. Davern, M. D. Wright, V. R. Herrmann, G. F. Mitchell, Mol. Biochem. Parasitol. 48, 67 (1991); S. Fitter, T A. Tetaz, M. C Berndt, L. K Ashman, Blood 86, 1348 (1995).
    • (1995) Blood , vol.86 , pp. 1348
    • Fitter, S.1    Tetaz, T.A.2    Berndt, M.C.3    Ashman, L.K.4
  • 51
    • 13344254162 scopus 로고    scopus 로고
    • note
    • We thank the Berkeley Drosophila Genome Center for providing mapped P-elements and J. P. Forjanic for suggesting the name late bloomer. C.C.K was supported as a Jane Coffin Childs Postdoctoral Fellow and a Howard Hughes Medical Institute Postdoctoral Associate, G W D. is an American Cancer Society Postdoctoral Fellow, and C.S.G. is an Investigator with HHMI.


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