Induction of p53-independent apoptosis by simian virus 40 small t antigen

Journal of Virology

Volumn 75, Issue 19, 2001, Pages 9142-9155

  Gjoerup, O ^a   Zaveri, D ^a   Roberts, T M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE INHIBITOR; PROTEIN BCL 2; PROTEIN P53; VIRUS T ANTIGEN;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CELL CYCLE; CELL TYPE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NICK END LABELING; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMIAN VIRUS 40; VIRUS MUTANT; VIRUS REPLICATION;

ANTIGENS, POLYOMAVIRUS TRANSFORMING; APOPTOSIS; HUMANS; PAPILLOMAVIRUS INFECTIONS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIMIAN VIRUS 40; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR VIRUS INFECTIONS; VIRUS REPLICATION;

EID: 0034847978     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.19.9142-9155.2001     Document Type: Article

References (88)

1. HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B
2. Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells
3. Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by upregulating FLICE/caspase-8
4. Apoptosis of Spodoptera frugiperda cells induced by okadaic acid is abrogated by baculovirus infection
5. Altered susceptibility to tumor necrosis factor alpha-induced apoptosis of mouse cells expressing polyomavirus middle and small T antigens
6. The t-unique coding domain is important to the transformation maintenance function of the simian virus 40 small t antigen
7. SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen
8. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
9. Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
10. Biochemical pathways of caspase activation during apoptosis
11. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication
12. Phosphatase 2A associated with polyomavirus small-T or middle-T antigen is an okadaic acid-sensitive tyrosyl phosphatase
13. High-efficiency transformation of mammalian cells by plasmid DNA
14. The induction of apoptosis by SV40 T antigen correlates with c-jun overexpression
15. Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice
16. Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells
17. Dual role of the HIV-1 vpr protein in the modulation of the apoptotic response of T cells
18. Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen
19. Protective effect of the insulin-like growth factor I receptor on apoptosis induced by okadaic acid
20. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
21. ARF tumor suppressor
22. The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen
23. A matter of life and cell death
24. The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice
25. Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity
26. The HIV-1 Vpr displays strong anti-apoptotic activity
27. pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression
28. Simian virus 40 gene A regulation of cellular DNA synthesis. II. In nonpermissive cells
29. Cell cycle progression in monkey cells expressing simian virus 40 small t antigen from adenovirus vectors
30. Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis
31. Mutational analysis of simian virus 40 small-t antigen
32. Cell cycle regulation and apoptosis
33. Inhibition of SV40 large T antigen induced apoptosis by small T antigen
34. E4orf4: A novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk
35. Apoptosis and mitotic arrest are two independent effects of the protein phosphatases inhibitor okadaic acid in K562 leukemia cells
36. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
37. The transforming activity of simian virus 40 large tumor antigen
38. Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Bα subunit of protein phosphatase 2A
39. The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis
40. Mutational analysis of polyomavirus small-T-antigen functions in productive infection and in transformation
41. Simian virus 40 functions required for the establishment and maintenance of malignant transformation
42. Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A
43. Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53
44. Dual role of HIV Tat in regulation of apoptosis in T cells
45. Regulation of protein kinase cascades by protein phosphatase 2A
46. The protein phosphatase inhibitors okadaic acid and calyculin A induce apoptosis in human osteoblastic cells
47. Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A
48. Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation
49. Okadaic acid-induced apoptosis in neuronal cells: Evidence for an abortive mitotic attempt
50. WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases
51. The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2
52. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A
53. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
54. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways
55. A novel simian virus 40 early region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays
56. The simian virus 40 small-t and large-T antigens jointly regulate cell cycle reentry in human fibroblasts
57. Regulation of p53 levels by the EIB 55-kilodalton protein and E4orf6 in adenovirus-infected cells
58. Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A
59. Viruses and apoptosis
60. Role of small t antigen in the acute transforming activity of SV40
61. Small-t and large-T antigens cooperate to drive cell proliferation
62. The role of the SV40 ST antigen in cell growth promotion and transformation
63. Role of NF-κB in p53-mediated programmed cell death
64. Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins
65. Cellular alterations dependent upon the polyoma virus Hr-t function: Separation of mitogenic from transforming capacities
66. Binding of polyomavirus small T antigen to protein phosphatase 2A is required for elimination of p27 and support of S-phase induction in concert with large T antigen
67. J domain-independent regulation of the Rb family by polyomavirus large T antigen
68. Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells
69. Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A
70. Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells
71. Simian virus 40 large T antigen J domain and Rb-binding motif are sufficient to block apoptosis induced by growth factor withdrawal in a neural stem cell line
72. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation
73. Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-κB activation
74. The aminoterminal transforming region of simian virus 40 large T and small t antigens functions as a J domain
75. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen
76. Small t protein of simian virus 40 is required for dense focus formation in a rat cell line
77. p53-dependent apoptosis suppresses tumor growth and progression in vivo
78. Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm
79. Protein phosphatase 2A: A panoply of enzymes
80. Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen
81. Requirement for ERK activation in cisplatin-induced apoptosis
82. Induction of cyclin D1 by simian virus 40 small tumor antigen
83. 2 during lytic infection
84. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation
85. Control of protein phosphatase 2A by simian virus 40 small-t antigen
86. 0 arrest and differentiation to apoptosis
87. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins