Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A

Molecular Pharmacology

Volumn 56, Issue 3, 1999, Pages 515-525

  Rajesh, Deepika ^a   Schell, Kathleen ^a   Verma, Ajit K ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; LIPOCORTIN 5; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN P53; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL FATE; CELL IMMORTALIZATION; CELL MUTANT; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40;

EID: 0032818585     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.3.515     Document Type: Article

References (53)

1. Aoki K, Yoshida T, Matsumoto N, Ide H, Sugimura T and Terada M (1997) Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras mutation but not those without Ki-ras mutation. Mol Carcinogenesis 20:251-258.
2. Boe R, Gjertsen BT, Vintermyr OK, Houge G, Lanotte M and Doskeland SO (1991) The protein phosphates inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res 195:237-246.
3. Bos JL (1989) ras Oncogenes in human cancer: A review. Cancer Res 49:4682-4689.
4. Cohen PTW (1997) 1 Novel protein serine/threonine phosphatases: Variety is the spice of life. Trends Biol Sci 22:245-251.
5. Cooper MJ, Haluschak JJ, Johnson D, Schwartz S, Morrison LJ, Lippa M, Hatzivassiliou G and Tan J (1994) p53 mutations in bladder carcinoma cell lines. Oncol Res 6:569-579.
6. Darzynkiewicz Z, Gong J, Juan G, Ardelt B and Tyraganos F (1996) Cytometry of cyclin proteins. Cytometry 25:1-13.
7. Darzynkiewicz Z, Li X and Gong J (1994) Assays of cell viability: Discrimination of cells dying by apoptosis. Methods Cell Biol 41:15-37.
8. Davis MA, Chang SH and Trump BF (1996) Differential sensitivity of normal and H-ras oncogene-transformed rat kidney epithelial cells to okadaic acid-induced apoptosis. Toxicol Appl Pharmacol 141:93-101.
9. Draetta G and Eckstein J (1997) Cdc25 protein phosphatases in cell proliferation. Biochim Biophys Acta 1332:M53-M63.
10. Fischer EH (1997) Cellular regulation by protein phosphorylation: A historical overview. Biofactors 6:367-374.
11. Fujiki H, Sueoka E, Komori A and Suganuma M (1997) Tumor promotion and TNF-α gene expression by the okadaic acid class tumor promoters. Environ Carcino Ecotox Revs 15:1-40.
12. Fujiki H and Suganuma M (1993) Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds. (Review) (170 refs). Adv Cancer Res 61:143-194.
13. Fujiki H, Suganuma M, Yoshizawa S, Kanazawa H, Sugimura T, Manam S, Kahn SM, Jiang W, Hoshina S and Weinstein IB (1989) Codon 61 mutations in the c-Harvey-ras gene in mouse skin tumors induced by 7, 12-dimethylbenz[a]anthracene plus okadaic acid class tumor promoters. Mol Carcinogen 2:184-187.
14. Galadari S, Kishikawa K, Kamibayashi C, Mumby MC and Hannun YA (1998) Purification and characterization of ceramide-activated protein phosphatases. Biochemistry 37:11232-11238.
15. Guy GR, Cao X, Chua SP and Tan YH (1992) Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1. J Biol Chem 267:1846-1852.
16. Hennings H, Lowry DT, Robinson VA, Morgan DL, Fujiki H and Yuspa SH (1992) Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis. Carcinogenesis 13:2145-2151.
17. Howe AK, Gaillard S, Bennett JS and Rundell K (1998) Cell cycle progression in monkey cells expressing simian virus 40 small t antigen from adenovirus vectors. J Virol 72:9637-9644.
18. Huang X-C, Richards EM and Summers C (1995) Angiotensin II type 2 receptor-mediated stimualtion of protein phosphatase 2A in rat hypothalamic/brainstem neuronal cocultures. J Neurochem 65:2131-2137.
19. Inomata M, Saijo N, Kawashima K, Kaneko A, Fujiwara Y, Kunikane H and Tanaka Y (1995) Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid. J Cancer Res Clin Oncol 121:729-738.
20. Israel K, Sanders BG and Klinek R (1995) RRR-alpha-tocophenryl succinate inhibits the proliferation of human prostatic tumor cells with defective cell cycle/ differentiation pathways. Nutri Cancer 24:161-9.
21. Kao C, Huang J, Wu S-Q, Hauser P and Reznikoff C (1993) Role of SV40 T antigen binding to pRb and p53 in multistep transformation in vitro of human uroepithelial cells. Carcinogenesis 14:2297-2302.
22. Kiguchi K, Glesne D, Chubb CH, Fujiki H and Huberman E (1994) Differential induction of apoposis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. Cell Growth Differ 5:995-1004.
23. Kim TW, Porter KL, Foley JF, Maronpot RR and Smart RC (1997) Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype. Mol Carcinogen 20:115-124.
24. Kloeker S, Bryant JC, Strack S, Colbran RJ and Wadzinski BE (1997) Carboxymethylation of nuclear protein serine/threonine phosphatase X. Biochem J 327:481-486.
25. Komori AT, Yatsunami J, Suganuma M, Okabe S, Abe S, Sakai A, Sakai A, Sasaki K and Fujiki H (1993) Tumor necrosis factor acts as a tumor promoter in BALB/ 3T3 cell transformation. Cancer Res 53:1982-1985.
26. Lehman TA, Bennett WP, Metcalf RA, Welsh JA, Ecker J, Modali RV, Ullrich S, Romano JW, Appaella E, Testa JR, Gerwin BI and Harris CC (1991) p53 Mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res 51:4090-4096.
27. Lerner EC, Hamilton AD and Sebti SM (1997) Inhibition of Ras prenylation: A signalling target for novel anti-cancer drug design. Anticancer Drug Design 12: 229-238.
28. Li DW, Pass U, Huizar I and Spector, A (1998) Okadaic acid-induced lens epithelial cell apoptosis requires inhibition of phosphatase-1 and is associated with induction of gene expression including p53 and bax. Eur J Biochem 257:351-361.
29. Marshall MS (1995) Ras target proteins in eukaryotic cells. FASEB J 9:1311-1318.
30. McCormick F (1995) Ras-related proteins in signal transduction and growth control. Mol Reprod Dev 42:500-506.
31. Morimoto Y, Ohba T, Kobayashi S and Haneji T (1997) The protein phosphatase inhibitors okadaic acid and calyculin A induce apoptosis in human osteoblastic cells. Exp Cell Res 230:181-186.
32. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
33. Mowat M (1998) p53 in tumor progression life death and everything. Adv Cancer Res 74:25-48.
34. Murata K, Mills I and Sumpio BE (1996) Protein phosphatase 2A in stretch-induced endothelial cell proliferation. J Cell Biochem 63:311-319.
35. st codon of the Ha-ras oncogene. Carcinogenesis 9:665-667.
36. Pergolizzi RG, Kries W, Rottach C, Susin M and Broome JD (1993) Mutational status of codons 12 and 13 of the N- and K-ras genes in tissues and cell lines derived from primary and metastatic prostate carcinomas. Cancer Invest 11:25-32.
37. Pratt CI, Kao C, Wu S-Q, Gilchrist KW, Oyasu R and Reznikoff CA (1992) Neoplastic progression by E/J ras at different steps of transformation in vitro of human uroepithelial cells. Cancer Res 52:688-695
38. Rosenberger SF and Bowden GT (1996) Okadaic acid stimulated TRE binding activity in a papilloma producing mouse keratinocyte cell line involves increased AP-1 expression. Oncogene 12:2301-2308.
39. Waft/cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of bax protein in human breast carcinoma cells. Cell Growth Differ 7:1599-1607.
40. Shirasawa S, Furuse M, Yokoyama N and Sasazukhi T (1993) Altered growth of human colon cell lines disrupted at activated ki-ras. Science 266:85-88.
41. Stanley, LA (1995) Molecular aspects of chemical carcinogenesis: The roles of oncogenes and tumor suppressor genes. Toxicology 96:173-194.
42. Strack S, Zaucha JA, Ebner FF, Colbran RJ and Wadzinski BE (1998) Brain protein phosphatase 2A: Developmental regulation and distinct cellular and subcellular localization by B subunits. J Comp Neurol 392:515-527.
43. Strickland JE, Greenbalgh DA, Koceva-Chyla A, Hennings M, Restrepo C, Balaschak M and Yuspa SM (1988) Development of murine epidermal cell lines which contain an activated ras Ha oncogene and from papillomas in skin grafts on athymic nude mouse hosts. Cancer Res 48:165-169.
44. Sun Y, Nakamura K, Hegamyer G, Dong Z and Colburn N (1993) No point mutation of Ha-ras or p53 genes expressed in preneoplastic-to-neoplastic progression as modeled in mouse JB6 cell variants. Mol Carcinogen 8:49-57.
45. Take Y, Kumano M, Teraoka H, Nishimura S and Okuyama A (1996) DNA-dependent protein kinase inhibitor (OK-1035) suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin. Biochem Biophys Res Commun 221: 207-212.
46. Taparowsky E, Suard Y, Fasano O, Shimizu K, Goldfarb M and Wigler M (1982) Activation of the T-24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature 300:762-765.
47. Tergau F, Weichert J, Quentin L, Opitz R, von Zezschwitz C, Marwitz J, Ritz V and Steinfelder HJ (1997) Inhibitors of ser/thr phosphatases 1 and 2A induce apoptosis in pituitary GH3 cells. Naunyn-Schmiedeberg Arch Pharmacol 356:8-16.
48. Turowski P, Fernandez A, Favre B, Lamb NJ and Hemmings BA (1995) Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression. J Cell Biol 128:297-410.
49. von Kleist S, Chany E, Burtin P, King M and Fogh J (1975) Immunology of the antigenic pattern of a continuous cell line from a human colon tumor. J Natl Cancer Inst 55:555-560.
50. Vojtek AB and Der CJ (1998) Increasing complexity of the Ras signaling pathway. J Biol Chem 273:19925-19928.
51. Yan Y, Shay JW, Wright WE and Mumby MC (1997) Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation. J Biochem Chem 272:15220-15226.
52. Yang SI, Lickteig RL, Estes R, Rundell K, Walter G and Mumby MC (1991) Control of protein phosphatase 2A by simian virus 40 small-t antigen. Mol Cell Biol 11:1988-1995.
53. Yatsunami J, Komori A, Ohta T, Suganuma M and Fujiki H (1993) Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoter. Cancer Res 53:239-241.