Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells

International Immunopharmacology

Volumn 1, Issue 11, 2001, Pages 1923-1937

  Elliott, Kathleen A ^a   Osna, Natalia A ^a   Scofield, Margaret A ^b   Khan, Manzoor M ^a  

^a CREIGHTON UNIVERSITY   (United States)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

H 8; Histamine; Interleukin 12; Interleukin 13; Janus kinase; Protein kinase A; Rp cAMPS; STAT6; Th2 lymphocytes; Tyrphostin AG490

Indexed keywords

ADENOSINE 3',5' PHOSPHOROTHIOATE; ANTIHISTAMINIC AGENT; CD3 ANTIGEN; CIMETIDINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DNA; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 13; IONOMYCIN; JANUS KINASE; MEPYRAMINE; MESSENGER RNA; MONOKINE; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN INHIBITOR; PROTEIN SUBUNIT; RANITIDINE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; THIOPERAMIDE;

ALLERGY; ANIMAL CELL; ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CLONE; LYMPHOID CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ASSAY; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TH2 CELL; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; CLONE CELLS; CULTURE MEDIA; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; HISTAMINE; HISTAMINE ANTAGONISTS; INDICATORS AND REAGENTS; INTERLEUKIN-13; KINETICS; MICE; RNA, MESSENGER; SPLEEN; TH2 CELLS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0034839238     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(01)00117-5     Document Type: Article

References (55)

1. Clonal diversity of IL-4 and IL-13 expression in human allergen-specific T lymphocytes
2. Activated mast cells produce interleukin-13
3. Differential regulation of IL-4 and IL-13 secretion by human basophils: Their relationship to histamine release in mixed leukocyte cultures
4. IL-13 released by and localized in human basophils
5. Human blood basophils produce interleukin13in response to IgE-receptor-dependent and -independent activation
6. Immunoregulatory properties of IL-13: Its potential role in atopic disease
7. Interleukin 13 is a B cell stimulating factor
8. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells
9. Role of IL-13 in CD4 T cell dependent IgE production in atopy
10. Genetic variants of IL-13 signaling and human asthma and atopy
11. Atopy and asthma: Genetic variants of IL-4 and IL-13 signaling
12. Signal transduction via the interleukin-4 receptor and its correlation with atopy
13. Atopy and the human IL-4 receptor alpha chain
14. The role of IL-13 in IgE synthesis by allergic asthma patients
15. Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD)
16. Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors
17. Histamine modulates the production of interferon-gamma and interleukin-2 by mitogen-activated human mononuclear blood cells
18. Dual control of human interleukin-2 and interferon-gamma gene expression by histamine: Activation and suppression
19. Histamine affects interleukin-4, interleukin-5, and interferon-gamma by T cell clones from the airways and blood
20. Histamine increases anti-CD3 induced IL-5 production of Th2-type T cells via histamine H2-receptors
21. Protein kinase A inhibitors reverse histamine-mediated regulation of IL-5 secretion
22. The effects of histamine on interferon gamma production are dependent on the stimulatory signals
23. Regulation of interleukin-10 secretion by histamine in Th2 cells and splenocytes
24. NK-mediated killing of AML blasts: Role of histamine, monocytes and reactive oxygen metabolites
25. Different modulation by histamine of IL-4 and interferon-gamma release according to the phenotype of human Th0, Th1 and Th2 clones
26. Involvement of protein kinase A in histamine-mediated inhibition of IL-2 mRNA expression in mouse splenocytes
27. Regulation of the cellular and subcellular concentrations and distribution of cyclic nucleotide-dependent protein kinases
28. The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response
29. Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway
30. Differential regulation of the activation of protein kinase A on the protein synthesis and secretion in the T-helper 2 cell line D10, G4.1
31. Adrenaline enhances LPS-induced IL-10 synthesis: Evidence for protein kinase A-mediated pathway
32. Anti-inflammatory activities of cAMP-elevating agents: Enhancement of IL-10 synthesis and concurrent suppression of TNF production
33. Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergen-specific human T lymphocyte clones
34. Cyclic AMP-elevating agents inhibit mite-antigen-induced IL-4 and IL-13 release from basophil-enriched leukocyte preparation
35. IL-13 production by allergen-stimulated T cells is increased in allergic disease and associated with IL-5 but not IFN-γ secretion
36. IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement
37. Differential regulation of antigen-induced IL-4 and IL-13 generation from T lymphocytes by IFN-α
38. Environmental antigen-induced IL-13 responses are elevated among subjects with allergic rhinitis, are independent of IL-4 and are inhibited by endogenous IFN-γ synthesis
39. Autocrine activation by interferon-gamma of STAT factors following T cell activation
40. Cellular responses to interferons and other cytokines: The JAK-STAT paradigm
41. Signal transduction in the interferon system
42. IL-4 induced STAT6 suppresses IFNγ-stimulated STAT1-dependent transcription in mouse macrophages
43. Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4
44. Structural comparison and chromosomal localization of the human and mouse IL-13 genes
45. Tyrphostin AG-490 inhibits cytokine-mediated Jak3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells
46. Constitutive activation of a slowly migration isoform of STAT3 in mycosis fungoides: Tyrphostin AG490 inhibits STAT3 activation and growth of mucosis fungoides tumor cell lines
47. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG 490 regulation of IL-2-mediated T cell response
48. The role of IL-13 and its receptor in allergy and inflammatory processes
49. Activation of type 1 protein kinase during receptor-mediated human T lymphocyte activation
50. Location of cAMP-dependent protein kinase type 1 with TCR-CD3 complex
51. Histamine type 1 (H1) receptor radioligand binding studies on normal T cell subsets, B cells and monocytes
52. Histamine modulation of lymphocyte biology: Membrane receptors, signal transduction and functions
53. Augmentation of antigen receptor-mediated responses by histamine H1 receptor signaling
54. Histaminergic transmission in mammalian brain
55. The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis