Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD)

Clinical and Experimental Immunology

Volumn 108, Issue 2, 1997, Pages 289-294

  Katagiri, K ^a   Itami, S ^a   Hatano, Y ^a   Takayasu, S ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

atopic dermatitis; IL 13; interferon gamma mRNA

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; MESSENGER RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; ATOPIC DERMATITIS; CELL LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; PSORIASIS VULGARIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0030906932     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.d01-1015.x     Document Type: Article

References (31)

1. Del Prete G, Maggi E, Parronchi P et al. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988; 140:4193-8.
2. Péne J, Rousset F, Briere F et al. IgE production by normal human lymphocytes is induced by interleukin-4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci USA 1988; 85:6880-4.
3. Vercelli D, Jabara HH, Arai K, Geha RS. Induction of human IgE synthesis requires interleukin-4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med 1989; 169:1295-307.
4. Vercelli D, Jabara HH, Lauener RP, Geha RS. IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures. J Immunol 1990; 144:570-3.
5. Defrance T, Carayon P, Billian G et al. Interleukin-13 is a B cell stimulating factor. J Exp Med 1994; 179:135-43.
6. Tang M, Kemp A, Varigos G. IL-4 and interferon-gamma production in children with atopic disease. Clin Exp Immunol 1993; 92:120-4.
7. Péne J, Rivier A, Lagier B et al. Differences in IL-4 release by PBMC are related with heterogeneity of atopy. Immunology 1994; 81:58-64.
8. Jujo K, Renz H, Abe J et al. Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis. J Allergy Clin Immunol 1992; 90:323-31.
9. Matumoto T, Miike T, Yamaguchi K et al. Serum levels of soluble IL-2 receptor, IL-4 and IgE-binding factors in childhood allergic diseases. Clin Exp Immunol 1991; 85:288-92.
10. Kasamatsu M, Tsuji T, Miura M. A method for the quantification of interleukin-4 in serum (sandwich ELISA) and IL-4 levels in patients with atopic dermatitis. Japanese Allerg 1993; 42:878-82.
11. Hashimoto S, Amemiya E, Tomita Y et al. Elevation of soluble IL-2 receptor and IL-4, and nonelevation of IFN-γ in sera from patients with allergic asthma. Ann Allergy 1993; 71:455-8.
12. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980; 92:44-47.
13. Rajka G, Langeland T. Grading of the severity of atopic dermatitis. Acta Derm Venereol (Stockh) 1989; 144:13-14.
14. Uyemura K, Yamamura M, Fivenson DF et al. The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type I cell-mediated reponse. J Invest Dermatol 1993; 101:701-5.
15. Schlaak JF, Buslau M, Jochum W et al. T cells involved in psoriasis vulgaris belong to the Th 1 subset. J Invest Dermatol 1994; 102:145-9.
16. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-9.
17. Gauchat JF, Gauchat D, De Week AL, Stadler BM. Cytokine mRNA levels in antigen-stimulated peripheral blood mononuclear cells. Eur J Immunol 1989; 19:1079-85.
18. Lewis DB, Charles CY, Meyer J et al. Cellular and molecular mechanisms for reduced interleukin-4 and interferon-γ production by neonatal T cells. J Clin Invest 1991; 87:194-202.
19. Byron KA, Liberatos S, Varigos GA, Wootton AM. Interferon-gamma production in atopic dermatitis: a role for prostaglandins? Int Arch Allergy Immunol 1992; 99:50-55.
20. Tang MLK, Kemp AS, Thorburn J, Hill DJ. Reduced Interferon-γ secretion in neonates and subsequent atopy. Lancet 1994; 344:983-5.
21. Tang ML, Varigos G, Kemp AS. Reduced interferon-gamma (IFN-γ) secretion with increased IFN-γ mRNA expression in atopic dermatitis: evidence for a post-transcriptional defect. Clin Exp Immunol 1994; 97:483-90.
22. McKenzie ANJ, Culpepper JA, de Waal Malefyt R et al. Interleukin-13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc Natl Acad Sci USA 1993; 90:3735-9.
23. Punnonen J, Aversa G, Cocks BG et al. Interleukin-13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993; 90:3730-4.
24. Zurawski G, de Vries JE. Interleukin-13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994; 15:19-26.
25. de Vries JE, Zurawski G. Immunoregulatory properties of IL-13: its potential role in atopic disease. Int Arch Allergy Immunol 1995; 106:175-9.
26. Horsmanheimo L, Harvima IT, Järvikallio A et al. Mast cells are one major source of interleukin-4 in atopic dermatitis. Br J Dermatol 1994; 131:348-53.
27. Bradding P, Feather IH, Howarth PH et al. Interleukin-4 is localized to and released by human mast cells. J Exp Med 1992; 176:1381-6.
28. Tang ML, Kemp AS. Spontaneous expression of IL-4 mRNA in lymphocytes from children with atopic dermatitis. Clin Exp Immunol 1994; 97:491-8.
29. + T cells to enhance priming for interferon gamma production and diminishes interleukin-4 inhibition of such priming. Proc Natl Acad Sci USA 1993; 90:10188-92.
30. Hamid Q, Boguniewicz M, Leung DY. Differential in situ cytokine gene expression in acute vs. chronic atopic dermatitis. J Clin Invest 1994; 94:870-6.
31. Grewe M, Walther S, Gyufko K et al. Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. J Invest Dermatol 1995; 105:407-10.