Activation or STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4

Journal of Immunology

Volumn 160, Issue 7, 1998, Pages 3385-3392

  Moriggl, Richard ^a   Kristofic, Colette ^b   Kinzel, Bernd ^b   Volarevic, Sinisa ^b   Groner, Bernd ^a   Brinkmann, Volker ^b  

^a TUMOR BIOLOGY CENTER   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

ARTICLE; DEPHOSPHORYLATION; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-12; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TH1 CELLS; TH2 CELLS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0032055197     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
2. Mosmann, T. R. 1991. Cytokine secretion patterns and cross-regulation of T cell subsets. Immunol. Res. 10:183.
3. Mosmann, T. R. 1991. Cytokines: is there biological meaning? Curr. Opin. Immunol. 3:311.
4. Romagnani, S. 1992. Induction of Th1 and Th2 responses: a key role for natural immune response? Immunol. Today 13:379.
5. Powrie, F., and R. S. Coffman. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol. Today 14:270.
6. + T cells. Annu. Rev. Immunol. 12:635.
7. Le Gros, G., S. Z. Ben Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of IL-4-producing cells in vivo and in vitro: IL-2 and IL-4 are required for the in vitro generation of IL-4 producing cells. J. Exp. Med. 172:921.
8. Demeure, C. E., C. Y. Wu, U. Shu, P. V. Schneider, C. Heusser, H. Yssel, and G. Delespesse. 1994. In vitro maturation of human neonatal lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production. J. Immunol. 152:4775.
9. - T cells develop into effector cells that secrete IL-13, IL-5, and IFN-γ, but no IL-4, and help efficient IgE production by B cells. J. Immunol. 154:3078.
10. Coffman, R. L., R. Correa-Oliviera, and S. Mocci. 1995. Reversal of polarized T helper 1 and T helper 2 cell populations in murine leishmaniasis. Ciba Found. Symp. 195:20.
11. Perez, V. L., J. A. Lederer, A. H. Lichtman, and A. K. Abbas. 1995. Stability of Th1 and Th2 populations. Int. Immunol. 7:869.
12. + T cells, analyzed at the single-cell level. J. Exp. Med. 184:473.
13. + T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J. Immunol. 156:3133.
14. Carballido, J. M., N. Carballido-Perrig, G. Terres, C. Heusser, and K. Blaser. 1992. Bee venom phospholipase A2-specific T cell clones from human allergic and non-allergic individuals: cytokine patterns change in response to the antigen concentration. Eur. J. Immunol. 22:1357.
15. 2-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:485.
16. - T cells by anti-CD28 plus IL-2: induction of clonal expansion and priming for a Th2 phenotype. J. Immunol. 156:4100.
17. Kopf, M., G. Gros, M. Bachmann, M. C. Lamers, H. Bluethmann, and G. Köhler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine response. Nature 362:245.
18. Gerosa, F., C. Paganin, D. Peritt, F. Paiola, M. T. Scupoli, M. Aste-Amezaga, I. Frank, and G. Trinchieri. 1996. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. J. Exp. Med. 183:2559.
19. Szabo, S. J., N. G. Jacobson, A. S. Dighe, U. Gubler, and K. M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2:665.
20. Brinkmann, V., T. Geiger, S. Alkan, and C. Heusser. 1993. IFN-α increases the frequency of IFN-γ-producing human CD4-positive T cells. J. Exp. Med. 178: 1655.
21. Schindler, C., and J. E. Darnell, Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621.
22. Ihle, J. N. 1996. Stats: signal transducers and activators of transcription. Cell 84:331.
23. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701.
24. Quelle, F. W., K. Shimoda, W. Thierfelder, C. Fischer, A. Kim, S. M. Ruben, J. L. Cleveland, J. H. Pierce, A. D. Keegan, K. Nelms, W. E. Paul, and J. N. Ihle. 1995. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15:3336.
25. Fenghao, X., A. Saxon, A. Nguyen, Z. Ke, D. Diaz Sanchez, and A. Nel. 1995. Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-γ activation site-like sequence upstream of the I epsilon exon in a human B cell line: evidence for the involvement of Janus kinase 3 and interleukin-4 Stat. J. Clin. Invest. 96:907.
26. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. E. Akira. 1996. Essential role of Stat6 in IL-4 signalling. Nature 380:627.
27. Heim, M. H., I. M. Kerr, G. R. Stark, and J. E. Damell. 1995. Contribution of Stat SH2 groups to specific interferon signaling by the Jak-Stat pathway. Science 267:1347.
28. Lederer, J. A., V. L. Perez, L. DesRoches, S. M. Kim, A. K. Abbas, and A. H. Lichtman. 1996. Cytokine transcriptional events during helper T cell subset differentiation. J. Exp. Med. 184:397.
29. Yu, C. R., J. X. Lin, D. W. Fink, S. Akira, E. T. Bloom, and A. Yamauchi. 1996. Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2. IL-12, and IFN-α. J. Immunol. 157:126.
30. Jacobson, N. G., S. J. Szabo, R. M. Weber Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181:1755.
31. Thierfelder, W. E., J. M. van Deursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. T. Carson, M. Y. Sangster, D. A. Vignali, P. C. Doherty, G. C. Grosveld, and J. N. Ihle. 1996. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382:171.
32. Bacon, C. M., E. F. Petricoin III, J. R. Ortaldo, R. C. Rees, A. C. Larner, J. A. Johnston, and J. J. O'Shea. 1995. Interleukin 12 induces tyrosine phosphorylation and activation of Stat4 in human lymphocytes. Prof. Natl. Acad. Sci. USA 92:7307.
33. Yamamoto, K., W. Quelle, W. E. Thierfelder, B. L. Kreider, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, O. Silvennoinen, and J. N. Ihle. 1994. Stat4, a novel γ interferon activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14:4342.
34. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313.
35. Kaplan, M. H., Y. L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.
36. David, M., E. Petricoin III, C. Benjamin, R. Pine, M. J. Weber, and A. C. Larner. 1995. Requirement for MAP kinase (ERK2) activity in interferon α- and interferon β-stimulated gene expression through Stat proteins. Science 269:1721.
37. Zhang, X., J. Blenis, H. C. Li, C. Schindler, and S. Chen-Kiang. 1995. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267:1990.
38. Wakao, H., F. Gouilleux, and B. Groner. 1994. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the PRL response. EMBO J. 13:2182.
39. Köhler, I., and E. P. Rieber. 1993. Allergy-associated I∈ and Fc∈ receptor II (CD23b) genes activated via binding of an interleukin-4-mduced transcription factor to a novel responsive element. Eur. J. Immunol. 23:3066.
40. Delphin, S., and J. Stavnezer. 1995. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline ∈ promoter: regulation by NF-IL-4, a C/EBP family member and NF-κB/p50. J. Exp. Med. 181: 181.
41. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
42. Zhong, Z., Z. Wen, and J. E. Darnell, Jr. 1994. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc. Natl. Acad. Sci. USA 91:4806.
43. Moriggl, R., S. Berchtold, K. Friedrich, G. J. R. Standke, W. Kammer, M. Heim, M. Wissler, E. Stöcklin, F. Gouilleux, and B. Groner. 1997. Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid and in mammary epithelial cells. Mol. Cell. Biol. 17:3663.
44. Sambrook, J., J. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Plainview, NY.
45. Szabo, S. L., N. G. Jacobson, A. S. Dighe, U. Gubler, and K. M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12-signaling. Immunity 2:665.
46. Alkan, S., C. Akdis, and H. Towbin. 1994. Chemoluminescent and enzyme-linked immuno assays for sensitive detection of human IFN-γ. J. Immunoassay 15:217.
47. + subsets. J. Immunol. 155:3322.
48. Wang, D., D. Stravopodis, S. Teglund, J. Kitazawa, and J. N. Ihle. 1996. Naturally occurring dominant negative variants of Stat5. Mol. Cell. Biol. 16:6141.
49. Schaefer, T. S., L. K. Sanders, and D. Nathans. 1995. Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. Proc. Natl. Acad. Sci. USA 92:9097.
50. Brinkmann, V., and B. Kinzel. 1997. IL-4 and IL-13 in atopy: regulation of production, and effects. In Molecular Mechanisms of IgE Regulation. D. Vercelli, ed. John Wiley and Sons, New York, p. 75.
51. Gouilleux-Gruart, V., F. Gouilleux, C. Desaint, J.-F. Claisse, J.-C. Capiod, J. Delobel, R. Weber-Nordt, I. Dusanter-Fourt, F. Dreyfus, B. Groner, and L. Prin. 1996. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87:1692.
52. Ho, I. C., M. R. Hodge, J. W. Rooney, and L. H. Glimcher. 1996. The protooncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85:973.
53. Hodge, M. R., H. J. Chun, J. Rengarajan, A. Alt, R. Lieberson, and L. Glimcher. 1996. NF-AT-driven interleukin-4 transcription potentiated by NIP45. Science 274:1903.
54. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
55. = T cells, interleukin 4 production is cytokine-autonomous, whereas IFN-γ production is cytokine-dependent. Proc. Natl. Acad. Sci. USA 94:3189.
56. Meraz, M. A., J. M. White, K. C. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, K. Carver-Moore, R. N. DuBois, R. Clark, M. Aguet, and R. D. Schreiber. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-Stat signaling pathway. Cell 84:431.
57. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443.
58. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, Y. C. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4:471.
59. Moriggl, R., V. Gouilleux-Gruart, R. Jähne, S. Berchtold, C. Gartmann, X. Liu, L. Hennighausen, A. Sotiropoulos, B. Groner, and F. Gouilleux. 1996. Deletion of the carboxyl terminal transactivation domain of MGF-Stat5 results in sustained DNA-binding and a dominant negative phenotype. Mol. Cell. Biol. 16:5691.
60. Haspel, R. L., M. Salditt-Georgieff, and J. E. Darnell. 1996. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J. 15:6262.
61. Shuai, K., J. Liao, and M. M. Song. 1996. Enhancement of antiproliferative activity of γ interferon by the specific inhibition of tyrosine dephosphorylation of Stat1. Mol. Cell. Biol. 16:4932.
62. Kim, T. K., and T. Maniatis. 1996. Regulation of interferon-γ-activated Stat1 by the ubiquitin-proteasome pathway. Science 273:1717.
63. Gollob, J. A., H. Kawasaki, and J. Ritz. 1997. Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur. J. Immunol. 27:647.
64. Manetti, R., F. Gerosa, M. G. Giudizi, R. Biagiotti, P. Parronchi, M. P. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. J. Exp. Med. 179:1273.
65. Hilkens C. M. U., G. Messer, K. Tesselaar, A. G. I Vanrietschoten, M. L. Kapsenberg, and E. A. Wierenga. 1996. Lack of IL-12 signaling in human allergen-specific Th2 cells. J. Immunol. 157:4316.