Atopy and the human IL-4 receptor α chain

Journal of Allergy and Clinical Immunology

Volumn 106, Issue 1, 2000, Pages S65-S71

  Izuhara, Kenji ^a,b,c   Yanagihara, Yukiyoshi ^a,b,d   Hamasaki, Naotaka ^a,b,c   Shirakawa, Taro ^a,b,e   Hopkin, Julian M ^a,b,e  

^a Faculty of Medicine Kyushu University ^*  (Japan)

^b Swansea   (United Kingdom)

^c KYUSHU UNIVERSITY   (Japan)

^d SAGAMIHARA NATIONAL HOSPITAL   (Japan)

^e UNIVERSITY OF WALES   (United Kingdom)

Author keywords

Atopy; IgE; IL 4 receptor chain; Signal transduction; Stat6

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 4 RECEPTOR; STAT PROTEIN;

ALPHA CHAIN; AMINO ACID ANALYSIS; ARTICLE; ATOPY; CONTROLLED STUDY; DISEASE ASSOCIATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; PREVALENCE; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; ASTHMA; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; ISOLEUCINE; LEUKOCYTES, MONONUCLEAR; PROMOTER REGIONS (GENETICS); RECEPTORS, IGE; RECEPTORS, INTERLEUKIN-4; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; VALINE; VARIATION (GENETICS);

EID: 0033911802     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2000.106776     Document Type: Article

References (51)

1. Izuhara K, Shirakawa T. Signal transduction via the interleukin-4 receptor and its correlation with atopy [review]. Int J Mol Med. 3:1999;3-10.
2. Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR. A genome-wide search for quantitative trait loci underlying asthma. Nature. 383:1996;247-250.
3. Deichmann KA, Heinzmann A, Forster J, Dischinger S, Mehl C, Brueggenolte E. Linkage and allelic association of atopy and markers flanking the IL4-receptor gene. Clin Exp Allergy. 28:1998;151-155.
4. Leonard WJ, Shores EW, Love PE. Role of the common cytokine receptor γ chain in cytokine signaling and lymphoid development. Immunol Rev. 148:1995;97-114.
5. Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ. cDNA cloning and characterization of the human interleukin 13 receptor a chain. J Biol Chem. 271:1996;29265-29270.
6. Murata T, Taguchi J, Puri RK. Interleukin-13 receptor α′ but not α chain: a functional component of interleukin-4 receptors. Blood. 91:1998;3884-3891.
7. Harada N, Yang G, Miyajima A, Howard M. Identification of an essential region for growth signal transduction in the cytoplasmic domain of human interleukin-4 receptor. J Biol Chem. 267:1992;22752-22758.
8. Lai SY, Molden J, Liu KD, Puck JM, White MD, Goldsmith MA. Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor α subunit. EMBO J. 15:1996;4506-4514.
9. Kammer W, Lischke A, Moriggl R, Groner B, Ziemiecki A, Gurniak CB. Homodimerization of interleukin-4 receptor a chain can induce intracellular signaling. J Biol Chem. 271:1996;23634-23637.
10. Fujiwara H, Hanissian SH, Tsytsykova A, Geha RS. Homodimerization of the human interleukin 4 receptor α chain induces Ce germline transcripts in B cells in the absence of the interleukin 2 receptor γ chain. Proc Natl Acad Sci USA. 94:1997;5866-5871.
11. Reichel M, Nelson BH, Greenberg PD, Rothman PB. The IL-4 receptor α-chain cytoplasmic domain is sufficient for activation of JAK-1 and STAT6 and the induction of IL-4-specific gene expression. J Immunol. 158:1997;5860-5867.
12. Schindler C, Darnell JE. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem. 64:1995;621-651.
13. Ihle JN. Cytokine receptor signaling. Nature. 377:1995;591-594.
14. Lin J, Migone T, Tsang M, Friedmann M, Weatherbee JA, Zhou L. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity. 2:1995;331-339.
15. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S. Essential role of Stat6 in IL-4 signaling. Nature. 380:1996;627-630.
16. Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 380:1996;630-633.
17. Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 4:1996;313-319.
18. Delphin S, Stavnezer J. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline e promoter : regulation by NF-IL-4, a C/EBP family member and NF-kB/p50. J Exp Med. 181:1995;181-192.
19. Mikita T, Campbell D, Wu P, Williamson K, Schindler U. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol Cell Biol. 16:1996;5811-5820.
20. Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol. 157:1996;3220-3222.
21. Khurana Hershey, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the a subunit of the interleukin-4 receptor. N Engl J Med. 337:1997;1720-1725.
22. Idzerda RL, March CJ, Mosley B, Lyman SD, Vanden Bos, Gimpel SD. Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med. 171:1990;861-873.
23. Galizzi J, Zuber CE, Harada N, Gorman DM, Djossou O, Kastelein R. Molecular cloning of a cDNA encoding the human interleukin 4 receptor. Int Immunol. 2:1990;669-675.
24. Mitsuyasu H, Izuhara K, Mao X, Gao P, Arinobu Y, Enomoto T. Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthma. Nat Genet. 19:1998;119-120.
25. Mitsuyasu H, Yanagihara Y, Mao X, Gao P, Arinobu Y, Ihara K. Dominant effect of Ile50Val variant of the human interleukin-4 receptor α chain in IgE synthesis. J Immunol. 162:1999;1227-1231.
26. Mao X, Shirakawa T, Yoshikawa K, Kawai M, Sasaki S, Enomoto T. Association between genetic variants of mast-cell chymase and eczema. Lancet. 348:1996;581-583.
27. Kunkel TA. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci USA. 82:1985;488-492.
28. Jenh C, Cox MA, Lundell D, Narula SK, Zavodny PJ. A highly sensitive and specific assay using a novel human growth hormone cDNA reporter gene regulated by the human interleukin-4 inducible germline ε transcript promoter. J Immunol Methods. 217:1998;87-95.
29. Izuhara K, Heike T, Otsuka T, Yamaoka K, Mayumi M, Imamura T. Signal transduction pathway of interleukin-4 and interleukin-13 in human B cells derived from X-linked severe combined immunodeficiency patients. J Biol Chem. 271:1996;619-622.
30. Izuhara K, Miyajima A, Harada N. The chimeric receptor between interleukin-2 receptor β chain and interleukin-4 receptor transduces interleukin-2 signal. Biochem Biophys Res Commun. 149:1001;995-1001.
31. Yanagihara Y, Kiniwa M, Kajiwara K, Shida T. Establishment of a sensitive radioimmunoassay for the detection of human IgE-binding factor (soluble CD23). Int Arch Allergy Immunol. 98:1992;189-199.
32. Yanagihara Y, Kajiwara K, Kiniwa M, Yui Y, Shida T, Delespesse G. Enhancement of IgE synthesis and histamine release by T cell factors derived from atopic patients with bronchial asthma. J Allergy Clin Immunol. 79:1987;448-456.
33. Cookson WO, Sharp PA, Faux JA, Hopkin JM. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet. 1:1989;1292-1295.
34. Cookson WO, Young RP, Sandford AJ, Moffatt MF, Shirakawa T, Sharp PA. Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet. 340:1992;381-384.
35. Sandford AJ, Shirakawa T, Moffatt MF, Daniels SE, Ra C, Faux JA. Localization of atopy and b subunit of high-affinity IgE receptor (FcεRI) on chromosome 11q. Lancet. 341:1993;332-334.
36. Shirakawa T, Li A, Dubowitz M, Dekker JW, Shaw AE, Faux JA. Association between atopy and variants of the β subunit of the high-affinity immunoglobulin E receptor. Nat Genet. 7:1994;125-129.
37. Hill MR, James AL, Faux JA, Ryan G, Hopkin JM, le Soüef P. FcεRI-β polymorphism and risk of atopy in a general population sample. Br Med J. 311:1995;776-779.
38. Hill MR, Cookson WO. A new variant of the β subunit of the high-affinity receptor for immunoglobulin E (FcεRI-β E237G): associations with measures of atopy and bronchial hyper-responsiveness. Hum Mol Genet. 5:1996;959-962.
39. Shirakawa T, Mao X, Sasaki S, Enomoto T, Kawai M, Morimoto K. Association between atopic asthma and a coding variant of FcεRIβ in a Japanese population. Hum Mol Genet. 5:1996;1129-1130.
40. Cox HE, Moffatt MF, Faux JA, Walley AJ, Coleman R, Trembath RC. Association of atopic dermatitis to the β subunit of the high affinity immunoglobulin E receptor. Br J Dermatol. 138:1998;182-187.
41. Hijazi Z, Haider MZ, Khan MR, Dowaisan AA. High frequency of IgE receptor FcεRIβ variant (Leu181/Leu183) in Kuwaiti Arabs and its association with asthma. Clin Genet. 53:1998;149-152.
42. Trabetti E, Cusin V, Malerba G, Martinati LC, Casartelli A, Boner AL. Association of the FcεRIβ gene with bronchial hyper-responsiveness in an Italian population. J Med Genet. 35:1998;680-681.
43. Green S, Gaillard MC, Song E, Dewar JB, Halks A. Polymorphisms of the β chain of the high affinity immunoglobulin E receptor (FcεRIβ) in South African black and white asthmatic and non-asthmatic individuals. Am J Respir Crit Care Med. 158:1998;1487-1492.
44. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Kautzky E. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science. 264:1994;1152-1156.
45. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI. Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 333:1995;894-900.
46. Noguchi E, Shibasaki M, Arinami T, Takeda K, Maki T, Miyamoto T. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population. Am J Respir Crit Care Med. 156:1997;1390-1393.
47. Ulbrecht M, Eisenhut T, Bonisch J, Kruse R, Wjst M, Heinrich J. High serum IgE concentrations: association with HLA-DR and markers on chromosome 5q31 and chromosome 11q13. J Allergy Clin Immunol. 99:1997;828-836.
48. Doull IJ, Lawrence S, Watson M, Begishvili T, Beasley RW, Lampe F. Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness. Am J Respir Crit Care Med. 153:1996;1280-1284.
49. Rosenwasser LJ, Borish L. Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10). Am J Respir Crit Care Med. 156:1997;S152-5.
50. Barnes KC, Neely JD, Duffy DL, Freidhoff LR, Breazeale DR, Schou C. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: evidence from Afro-Caribbean and Caucasian populations. Genomics. 37:1996;41-50.
51. Schulte T, Kurrle R, Röllinghoff M, Gessner A. Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes. J Exp Med. 186:1997;1419-1429.