Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor

European Journal of Biochemistry

Volumn 268, Issue 3, 2001, Pages 819-825

  Maccarrone, Mauro ^a   Bari, Monica ^a   Menichelli, Adriana ^a   Giuliani, Elena ^b   Principe, Domenico Del ^a   Finazzi Agrò, Alessandro ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b Croce Rossa Italiana   (Italy)

Author keywords

2 arachidonoylglycerol; 5 hydroxytryptamine (serotonin); ADP; Cannabinoid receptors; Platelet

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANANDAMIDE; CALCIUM; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; COLLAGEN; CYCLIC AMP; FATTY ACID AMIDASE; INOSITOL 1,4,5 TRISPHOSPHATE; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; RIMONABANT; SEROTONIN;

ARTICLE; CALCIUM CELL LEVEL; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG DEGRADATION; DRUG UPTAKE; HUMAN; HUMAN CELL; HYDROLYSIS; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE RICH PLASMA;

ADENOSINE DIPHOSPHATE; AMIDOHYDROLASES; ARACHIDONIC ACIDS; ASPIRIN; BIOLOGICAL TRANSPORT; BLOOD PLATELETS; BORNANES; CALCIUM CHANNEL BLOCKERS; COLLAGEN; CYCLIC AMP; ENDOCANNABINOIDS; GLYCERIDES; HUMANS; HYDROLYSIS; INOSITOL 1,4,5-TRISPHOSPHATE; KINETICS; PIPERIDINES; PLATELET ACTIVATION; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SEROTONIN; TIME FACTORS;

EID: 0034825356     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.01942.x     Document Type: Article

References (32)

1. Comparative biology of the endocannabinoid system. Possible role in the immune response
2. Evidence that 2-arachidonoylglycerol but not N-palmitoylethano-lamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells
3. Mesenteric vasodilation mediated by endothelial anandamide receptors
4. Cardiovascular effects of 2-arachidono-yl glycerol in anesthetized mice
5. Production and physiological actions of anandamide in the vasculature of the rat kidney
6. Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: Is 2-arachidonoylglycerol a possible vasomodulator?
7. Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages
8. Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension
9. Anandamide activates human platelets through a pathway independent of the arachidonate cascade
10. Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid
11. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets
12. Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
13. ADP, adrenaline and serotonin stimulate inositol 1,4,5-trisphosphate production in human platelets
14. Effects of serotonin on platelet activation in whole blood
15. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
16. Modification of 5-HT2 receptor mediated behaviour in the rat by oleamide and the role of cannabinoid receptors
17. 3H(N)]arachidonoyl-glycerol (2-AG), a putative endogenous cannabinoid receptor ligand
18. Hydrogen peroxide has a role in the aggregation of human platelets
19. Uptake of adenosine and of adenosine diphosphate by human blood platelets
20. 2+ response among human platelets measured using fluo-3 and fluorescent videomicroscopy
21. Down-regulation of anandamide hydrolase in mouse uterus by sex hormones
22. Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol
23. Human mast cells take up and hydrolyze anandamide under the control of 5-lipoxygenase, and do not express cannabinoid receptors
24. Anandamide hydrolysis by human cells in culture and brain
25. Pharmacology of cannabinoid CB1 and CB2 receptors
26. Structural determinants for recognition and translocation by the anandamide transporter
27. Defective platelet activation in G alpha (q)-deficient mice
28. Structural basis for selective inhibition of cyclo-oxygenase-2 by anti-inflammatory agents
29. Inhibitors of arachidonoyl ethanolamide hydrolysis
30. The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: Connections with anandamide
31. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
32. Anandamide uptake by human endothelial cells and its regulation by nitric oxide