Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt

Molecular and Cellular Biology

Volumn 21, Issue 19, 2001, Pages 6706-6717

  Zugasti, O ^a   Rul, W ^a   Roux, P ^a   Peyssonnaux, C ^a   Eychene, A ^a   Franke, T F ^a   Fort, P ^a   Hibner, U ^a  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC42; PROTEIN KINASE B; PROTEIN P53; RAC1 PROTEIN; RAF PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBROBLAST; GENE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; ANOIKIS; APOPTOSIS; CDC42 GTP-BINDING PROTEIN; CELL NUCLEUS; CELLS, CULTURED; EXTRACELLULAR MATRIX; FIBROBLASTS; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RAC1 GTP-BINDING PROTEIN; RHO GTP-BINDING PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034816501     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.19.6706-6717.2001     Document Type: Article

References (59)

1. Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf
2. Cell adhesion molecules, signal transduction and cell growth
3. Ras and Rho GTPases: A family reunion
4. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
5. Signal transduction: Hanging on a scaffold
6. Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
7. Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor
8. Phosphatidylinositol 3-kinase regulates raf1 through Pak phosphorylation of serine 338
9. Serine/threonine protein kinases and apoptosis
10. Autoregulation of the Raf-1 serine/threonine kinase
11. Cellular survival: A play in three Akts
12. Murine Ksr interacts with MEK and inhibits Ras-induced transformation
13. A matter of life and cell death
14. Apoptosis. A Bad kinase makes good
15. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
16. Integrins and anoikis
17. Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways
18. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
19. Integrin signaling: Specificity and control of cell survival and cell cycle progression
20. Negative Regulation of the Serine/Threonine Kinase B-Raf by Akt
21. Integrin signaling and cell growth control
22. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
23. p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression
24. Glucosylation of Rho proteins by Clostridium difficile toxin B
25. Suppression of c-myc-induced apoptosis by Ras signalling through PI(3)K and PKB
26. High-intensity Raf signals convert mitotic cell cycling into cellular growth
27. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
28. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
29. Detection and quantification of apoptosis in transiently transfected adherent cells
30. Extinction of Rac1 and Cdc42Hs signaling defines a novel p53 dependent apoptotic pathway
31. The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal
32. Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: A mechanism leading to increased malignancy in epithelial cells
33. A brain serine/threonine protein kinase activated by Cdc42 and Rac1
34. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C
35. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
36. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
37. The complexity of Raf-1 regulation
38. Anti-apoptotic function of Rac in hematopoietic cells
39. Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin-and PDGF-stimulated 3T3-L1 adipocytes
40. Rho and Rac exert antagonistic functions on spreading of macrophage-derived multinucleated cells and are not required for actin fiber formation
41. Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf
42. Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity
43. Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts
44. PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity
45. Regulation of inositol lipid kinases by Rho and Rac
46. Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt
47. The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform N1H3T3 cells
48. Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: Inhibition by PKB/Akt but not Raf signalling
49. Protein kinases: Six degrees of separation?
50. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
51. Interactions between mitogenic stimuli, or, a thousand and one connections
52. Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation
53. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
54. The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation
55. Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase. Cdc42/Rac and Pak
56. Apoptosis in the pathogenesis and treatment of disease
57. The extracellular signal-regulated kinase pathway is required for activation-induced cell death of T cells
58. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
59. Phosphorylation and regulation of Raf by Akt (protein kinase B)