Insertion of foreign DNA into an established mammalian genome can alter the methylation of cellular DNA sequences

Journal of Virology

Volumn 73, Issue 2, 1999, Pages 1010-1022

  Remus, Ralph ^a   Kämmer, Christina ^a   Heller, Hilde ^a   Schmitz, Birgit ^a   Schell, Gudrun ^a   Doerfler, Walter ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGE DNA; PLASMID DNA;

ADENOVIRUS; ANIMAL CELL; ARTICLE; BACTERIOPHAGE LAMBDA; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA METHYLATION; DNA MODIFICATION; DNA SEQUENCE; DNA TRANSFER; GENE INSERTION; GENETIC TRANSCRIPTION; HAMSTER; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RETROPOSON;

EID: 0345435970     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.2.1010-1022.1999     Document Type: Article

References (45)

1. Achten, S., A. Behn-Krappa, M. Jücker, J. Sprengel, I. Hölker, B. Schmitz, H. Tesch, V. Diehl, and W. Doerfler. 1991. Patterns of DNA methylation in selected human genes in different Hodgkin's lymphoma and leukemia cell lines and in normal human lymphocytes. Cancer Res. 51:3702-3709.
2. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium isothiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
3. Doerfler, W. 1981. DNA methylation - a regulatory signal in eukaryotic gene expression. J. Gen. Virol. 57:1-20.
4. Doerfler, W. 1983. DNA methylation and gene activity. Annu. Rev. Biochem. 52:93-124.
5. Doerfler, W., R. Gahlmann, S. Stabel, R. Deuring, U. Lichtenberg, M. Schulz, D. Eick, and R. Leisten. 1983. On the mechanism of recombination between adenoviral and cellular DNAs: the structure of junction sites. Curr. Top. Microbiol. Immunol.109:193-228.
6. Doerfler, W. 1995. The insertion of foreign DNA into mammalian genomes and its consequences: a concept for oncogenesis. Adv. Cancer Res. 66:313-344.
7. Doerfler, W. 1996. A new concept in (adenoviral) oncogenesis: integration of foreign DNA and its consequences. Biochim. Biophys. Acta Rev. Cancer 1288:F79-F99.
8. Ehrlich, M., and R. Y. Wang. 1981. 5-Methylcytosine in eukaryotic DNA. Science 212:1350-1357.
9. Feinberg, A. P., and B. Vogelstein. 1983. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301: 89-92.
10. Feinberg, A. P., and B. Vogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:5-13.
11. Frommer, M., L. E. McDonald, D. S. Millar, C. M. Collis, F. Watt, G. W. Grigg, P. L. Molloy, and C. L. Paul. 1992. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. USA 89:1827-1831.
12. Graham, F. L., and A. J. van der Eb. 1973. Transformation of rat cells by DNA of human adenovirus 5. Virology 54:536-539.
13. Günthert, U., M. Schweiger, M. Stupp, and W. Doerfler. 1976. DNA methylation in adenovirus, adenovirus-transformed cells, and host cells. Proc. Natl. Acad. Sci. USA 73:3923-3927.
14. Hanahan, D. 1983. Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 166:557-580.
15. Heller, H., C. Kämmer, P. Wilgenbus, and W. Doerfler. 1995. The chromosomal insertion of foreign (adenovirus type 12, plasmid or bacteriophage λ) DNA is associated with enhanced methylation of cellular DNA segments. Proc. Natl. Acad. Sci. USA 92:5515-5519.
16. Hilger-Eversheim, K., and W. Doerfler. 1997. Clonal origin of adenovirus type 12-induced hamster tumors: non-specific chromosomal integration sites of viral DNA. Cancer Res. 57:3001-3009.
17. Keshet, I., J. Lieman-Hurwitz, and H. Cedar. 1986. DNA methylation affects the formation of active chromatin. Cell 44:535-543.
18. Knoblauch, M., J. Schröer, B. Schmitz, and W. Doerfler. 1996. The structure of integration sites of adenovirus type 12 DNA in the hamster cell genome. J. Virol. 70:3788-3796.
19. Koetsier, P. A., J. Schorr, and W. Doerfler. 1993. A rapid optimized protocol for downward alkaline Southern blotting of DNA. BioTechniques 15:260-262.
20. Kuff, E. L., J. E. Fewell, K. K. Lueders, J. A. DiPaolo, S. C. Amsbaugh, and N. C. Popescu. 1986. Chromosome distribution of intracisternal A-particle sequences in the Syrian hamster and mouse. Chromosoma 93:213-219.
21. Lichter, P., C.-J. C. Tang, K. Call, G. Hermanson, G. A. Evans, D. Housman, and D. C. Ward. 1990. High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science 247:64-69.
22. Lubbert, M., C. W. Miller, and H. P. Koeffler. 1991. Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation. Blood 78:345-356.
23. Meyer zu Altenschildesche, G., H. Heller, P. Wilgenbus, S. T. Tjia, and W. Doerfler. 1996. Chromosomal distribution of the hamster intracisternal A particle (IAP) retrotransposons. Chromosoma 104:341-344.
24. Munnes, M., G. Patrone, B. Schmitz, G. Romeo, and W. Doerfler. 1998. A 5′-CG-3′-rich region in the promoter of the transcriptionally frequently silenced RET protooncogene lacks methylated cytidine residues. Oncogene 17:2573-2584.
25. Ono, M., H. Toh, T. Miyata, and T. Awaya. 1985. Nucleotide sequence of the Syrian hamster intracisternal A-particle gene: close evolutionary relationship of type A particle gene to types B and C oncovirus genes. J. Virol. 55:387-394.
26. Orend, G., I. Kuhlmann, and W. Doerfler. 1991. Spreading of DNA methylation across integrated foreign (adenovirus type 12) genomes in mammalian cells. J. Virol. 65:4301-4308.
27. Orend, G., M. Knoblauch, C. Kämmer, S. T. Tjia, B. Schmitz, A. Linkwitz, G. Meyer zu Altensehildesche, J. Maas, and W. Doerfler. 1995. The initiation of de novo methylation of foreign DNA integrated into a mammalian genome is not exclusively targeted by nucleotide sequence. J. Virol. 69:1226-1242.
28. Ortin, J., K.-H. Scheidtmann, R. Greenberg, M. Westphal, and W. Doerfler. 1976. Transcription of the genome of adenovirus type 12. III. Maps of stable RNA from productively infected human cells and abortively infected and transformed hamster cells. J. Virol. 20:355-372.
29. Razin, A., and A. D. Riggs. 1980. DNA methylation and gene function. Science 210:604-610.
30. Rideout, W. M., III., P. Eversole-Cire, C. H. Spruck III, C. M. Hustad, G. A. Coetzee, F. A. Gonzales, and P. A. Jones. 1994. Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation. Mol. Cell. Biol. 14:6143-6152.
31. Rigby, P. W. J., M. Dieckmann, C. Rhodes, and P. Berg. 1977. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J. Mol. Biol. 113:237-251.
32. Rosahl, T., and W. Doerfler. 1992. Alterations in the levels of expression of specific cellular genes in adenovirus-infected and -transformed cells. Virus Res. 26:71-90.
33. Schröer, J., I. Hölker, and W. Doerfler. 1997. Adenovirus type 12 DNA firmly associates with mammalian chromosomes early after virus infection or after DNA transfer by the addition of DNA to the cell culture medium. J. Virol. 71:7923-7932.
34. Schubbert, R., C. M. Lettmann, and W. Doerfler. 1994. Ingested foreign (phage M13) DNA survives transiently in the gastrointestinal tract and enters the bloodstream of mice. Mol. Gen. Genet. 242:495-504.
35. Schubbert, R., D. Renz, B. Schmitz, and W. Doerfler. 1997. Foreign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be convalently linked to mouse DNA. Proc. Natl. Acad. Sci. USA 94:961-966.
36. Schumacher, A., K. Buiting, M. Zeschnigk, W. Doerfler, and B. Horsthemke. 1998. Methylation analysis of the PWS/AS region does not support an enhancer-competition model. Nat. Genet. 19:324-325.
37. Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503-517.
38. Southern, P. J., and P. Berg. 1982. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genetics 1:327-341.
39. Stabel, S., W. Doerfler, and R. R. Friis. 1980. Integration sites of adenovirus type 12 DNA in transformed hamster cells and hamster tumor cells. J. Virol. 36:22-40.
40. Strohl, W. A., H. Rouse, K. Teets, and R. W. Schlesinger. 1970. The response of BHK21 cells to infection with type 12 adenovirus. III. Transformation and restricted replication of superinfecting type 2 adenovirus. Arch. Gesamte Virusforsch. 31:93-113.
41. Sutter, D., and W. Doerfler. 1980. Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely correlated with viral gene expression. Proc. Natl. Acad. Sci. USA 77:253-256.
42. Sutter, D., M. Westpahl, and W. Doerfler. 1978. Patterns of integration of viral DNA sequences in the genomes of adenovirus type 12-transformed hamster cells. Cell 14:569-585.
43. Taruscio, D., and L. Manuelidis. 1991. Integration site preferences of endogenous retroviruses. Chromosoma 101:141-156.
44. Yisraeli, J., R. S. Adelstein, D. Melloul, U. Nudel, D. Yaffa, and H. Cedar. 1986. Muscle-specific activation of a methylated chimeric actin gene. Cell 46: 409-416.
45. Zeschnigk, M., B. Schmitz, B. Dittrich, K. Buiting, B. Horsthemke, and W. Doerfler. 1997. Imprinted segments in the human genome: different DNA methylation patterns in the Prader-Willi/Angelman syndrome region as determined by the genomic sequencing method. Hum. Mol. Genet. 6:387-395.