Active repression and E2F inhibition by pRB are biochemically distinguishable

Genes and Development

Volumn 15, Issue 4, 2001, Pages 392-397

  Ross, John F ^a,c   Näär, Anders ^b   Cam, Hieu ^a   Gregory, Richard ^a   Dynlacht, Brian David ^a  

^a HARVARD UNIVERSITY   (United States)

^b University of California Berkeley   (United States)

^c PFIZER INC   (United States)

Author keywords

Chromatin; E2F; pRB; Transcriptional repression

Indexed keywords

RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ARTICLE; CHROMATIN; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

CARRIER PROTEINS; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; HISTONE DEACETYLASES; HUMANS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0035119507     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.858501     Document Type: Article

References (27)

1. The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter
2. Retinoblastoma protein recruits histone deacetylase to repress transcription
3. Direct transcriptional repression by pRB and its reversal by specific cyclins
4. Biochemical reconstitution of chromatin with physiological nucleosome spacing
5. Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function
6. Role of the LXCXE binding site in Rb function
7. Physical interaction of the retinoblastoma protein with human D cyclins
8. Differential regulation of E2F trans-activation by cyclin-cdk2 complexes
9. Specific regulation of E2F family members by cyclin-dependent kinases
10. The regulation of E2F by pRB-family proteins
11. ATP-Dependent histone octamer sliding mediated by the chromatin remodeling complex NURF
12. ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly
13. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins
14. Rb interacts with histone deacetylase to repress transcription
15. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
16. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
17. Role of nucleosome remodeling factor NURF in transcriptional activation of chromatin
18. Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro
19. Composite co-activator ARC mediates chromatin-directed transcriptional activation
20. Mechanism of transcriptional repression of E2F by the retinoblastoma tumor suppressor protein
21. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
22. Histone acetyltransferases regulate HIV-1 enhancer activity in vitro
23. ATP-dependent chromatin-remodeling complexes
24. Mechanism of active transcriptional repression by the retinoblastoma protein
25. Alteration of nucleosome structure as a mechanism of transcriptional regulation
26. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p161NK4a, TGFβ, and contact inhibition
27. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF