Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 4, 1999, Pages 581-588

  Marquis, Robert W ^a   Ru, Yu ^a   Yamashita, Dennis S ^a   Oh, Hye Ja ^a   Yen, Jack ^a   Thompson, Scott K ^a   Carr, Thomas J ^a   Levy, Mark A ^a   Tomaszek, Thaddeus A ^a   Ijames, Carl F ^a   Smith, Ward W ^a   Zhao, Baoguang ^a   Janson, Cheryl A ^a   Abdel Meguid, Sherin S ^a   D'Alessio, Karla J ^a   McQueney, M S ^a   Veber, Daniel F ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Alkoxymethylketone; Cathepsin K; Cysteine protease; Enzyme inhibitor; Thiomethylketone

Indexed keywords

CATHEPSIN K; CYSTEINE PROTEINASE INHIBITOR; KETONE DERIVATIVE;

CONFERENCE PAPER; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CATHEPSIN B; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENDOPEPTIDASES; KETONES; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR;

EID: 0033029816     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00011-5     Document Type: Conference Paper

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