Cathepsin K in thyroid epithelial cells: Sequence, localization and possible function in extracellular proteolysis of thyroglobulin

Journal of Cell Science

Volumn 113, Issue 24, 2000, Pages 4487-4498

  Tepel, C ^a   Bromme D ^a   Herzog, V ^a   Brix, K ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Cathepsin; Epithelial cell; Lysosome; Thyroglobulin; Thyroid gland

Indexed keywords

ASPARAGINE; CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; COMPLEMENTARY DNA; CYSTEINE; CYSTEINE PROTEINASE; ENZYME PRECURSOR; HISTIDINE; LYSOSOME ENZYME; RECOMBINANT ENZYME; THYROGLOBULIN; THYROXINE;

AMINO ACID SEQUENCE; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CELL SURFACE; CELL TYPE; CONTROLLED STUDY; CYTOCHEMISTRY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME RELEASE; EPITHELIUM CELL; GLYCOSYLATION; IN VITRO STUDY; LYSOSOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PREDICTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SPECIES; SWINE; THYROID FOLLICLE; THYROID GLAND; THYROID HORMONE RELEASE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; DNA, COMPLEMENTARY; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; THYROGLOBULIN; THYROID GLAND;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0034502852     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Substrate specificity of recombinant osteoclast-specific cathepsin K from rabbits
2. Regulated secretion of conventional lysosomes
3. Cathepsin B, Cathepsin H, and cathepsin L
4. Multimerization of thyroglobulin (TG) during extracellular storage: Isolation of highly cross-linked TG from human thyroids
5. Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells
6. Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution
7. Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme
8. LDL-receptor structure. Calcium cages, acid baths and recycling receptors
9. Expression of Cathepsin K in lung epithelial cells
10. Emerging roles for cysteine proteases in human biology
11. Cathepsin K, but not cathepsin B, L or S, is abundantly expressed in human osteoclasts
12. Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: Implications for protein engineering
13. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
14. Cathepsin K: Isolation and characterization of the murine cDNA and genomic sequence, the homologue of the human pycnodysostosis gene
15. Structure and chromosomal assignment of the human cathepsin K gene
16. Isolation and cloning of JTAP-1: A cathepsin like gene upregulated in response to V-Jun induced cell transformation
17. Expression of cathepsin K in the human embryo and fetus
18. Micropuncture investigation of the anion content of colloid from single rat thyroid follicles. A micromethod for the simultaneous determination of iodide and chloride in nanomole quantities
19. Isolation of insoluble secretory product from bovine thyroid: Extracellular storage of thyroglobulin in covalently cross-linked form
20. Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP)
21. Cysteine proteinase Cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction
22. Molecular cloning of human cDNA for cathepsin K: Novel cysteine proteinase predominantly expressed in bone
23. Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix
24. Cathepsin S and related lysosomal endopeptidases
25. Cathepsin L. A new proteinase from rat-liver lysosomes
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
27. Iodination of mature cathepsin D in thyrocytes as an indicator for its transport to the cell surface
28. Subcellular distribution, secretion, and posttranslational modifications of clusterin in thyrocytes
29. Characterization of mouse Cathepsin K gene, the gene promotor, and the gene expression
30. Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas
31. The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma
32. Cynomolgus monkey (Macaca fascicularis) Cathepsin K: Cloning, expression, purification, and activation
33. Primary structure of bovine thyroglobulin deduced from the sequence of its 8,431-base complementary DNA
34. Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH
35. Gene expression of proteases and protease inhibitors in the human ciliary epithelium and ODM-2 cells
36. Sequence analysis, tissue distribution, and expression of rat cathepsin S
37. Improved tools for biological sequence comparison
38. Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development
39. Proteolytic enzyme activity of colloid extracted from single follicles of the rat thyroid
40. Covalent cross-linking of secreted bovine thyroglobulin by transglutaminase
41. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
42. Mannose 6-phosphate receptor in procine thyroid follicle cells. Localization and possible implications for the intracellular transport of thyroglobulin
43. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2
44. Cathepsin B and its endogenous inhibitors: The role in tumor malignancy
45. A microgel electrophoretic analysis of the colloid proteins in single rat thyroid follicles. II. The protein concentration of the colloid single rat thyroid follicles
46. Cathepsin B activity in human lung tumor cell lines: Ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level
47. Cathepsin expression during skeletal development
48. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
49. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts
50. Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice
51. Immunocytochemical localization of cathepsin B, H, L, and T4 in follicular cells of rat thyroid gland
52. Molecular recognition and targeting of lysosomal proteins
53. Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S
54. Evaluation and characterization of a porcine small intestine cDNA library