Mechanisms of ionomycin-induced endothelial cell barrier dysfunction

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 273, Issue 1 17-1, 1997, Pages

  Garcia, Joe G N ^a,b   Schaphorst, Kane L ^a   Shi, Shu ^a   Verin, Alexander D ^a   Hart, C Michael ^a   Callahan, Karleen S ^a   Patterson, Carolyn E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Adenosine 3',5'; Cyclic monophosphate; Focal adhesion kinase; Myosin light chain kinase; Protein kinase A; Tyrosine phosphorylation

Indexed keywords

ALBUMIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FOCAL ADHESION KINASE; IONOMYCIN; MYOSIN LIGHT CHAIN KINASE; PHOSPHATASE; PROTEIN TYROSINE KINASE; THROMBIN;

ANIMAL CELL; ARTICLE; CATTLE; ELECTRIC RESISTANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; LUNG BLOOD VESSEL; MONOLAYER CULTURE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VASCULAR ENDOTHELIUM;

EID: 0030838457     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1997.273.1.l172     Document Type: Article

References (46)

1. Beckerle, M. C., K. Burridge, G. N. DeMartino, and D. E. Croall. Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion. Cell 51: 569-577, 1987.
2. Carson, M. R., S. S. Shasby, and D. M. Shasby. Histamine and inositol phosphate accumulation in endothelium: cAMP and a G protein. Am. J. Physiol. 257 (Lung Cell. Mol. Physiol. 1): L259-L264, 1989.
3. FAK. Mol. Cell. Biol. 14: 147-155, 1994.
4. Gallagher, P. J., J. G. N. Garcia, and B. P. Herring. Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells. J. Biol. Chem. 270: 29090-29095, 1995.
5. Garcia, J. G. N., A. S. Birnboim, R. Bizios, P. J. Del Vecchio, J. W. Fenton, and A. B. Malik. Thrombin-induced increases in albumin clearance across cultured endothelial monolayers. J. Cell. Physiol. 128: 96-104, 1986.
6. Garcia, J. G. N., H. W. Davis, and C. E. Patterson. Regulation of endothelial cell myosin light chain phosphorylation. Role in thrombin-induced barrier dysfunction. J. Cell. Physiol. 163: 510-522, 1995.
7. Garcia, J. G. N., R. F. Dodson, and K. S. Callahan. Effect of environmental particulates on cultured human and bovine endothelium: cellular injury via an oxidant-dependent pathway. Lab. Invest. 61: 53-61, 1989.
8. 2+ mobilization, and prostacyclin synthesis in cultured human endothelium: further evidence for regulation by a pertussis toxin-insensitive guanine nucleotide-binding protein. Am. J. Respir. Cell Mol. Biol. 5: 113-124, 1991.
9. Garcia, J. G. N., J. W. Fenton, and V. Natarajan. Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3′,5′-monophosphate. Blood 79: 2056-2067, 1992.
10. Garcia, J. G. N., V. Lazar, L. Gilbert-McClain, P. J. Gallagher, and A. Verin. Myosin light chain kinase in endothelium: molecular cloning and regulation. Am. J. Respir. Cell Mol. Biol. 16: 489-494, 1997.
11. Garcia, J. G. N., R. G. Painter, J. W. Fenton, D. English, and K. S. Callahan. Thrombin-induced prostacyclin biosynthesis in human endothelium: role of guanine nucleotide regulatory proteins in stimulus/coupling responses. J. Cell. Physiol. 142: 186-193, 1990.
12. 2 synthesis, PDGF mRNA expression, and barrier dysfunction in vascular endothelium. J. Cell. Physiol. 156: 541-549, 1993.
13. Garcia, J. G. N., J. E. Stasek, V. Natarajan, C. E. Patterson, and J. D. Dominguez. Role of protein kinase C in the regulation of prostaglandin synthesis in human endothelium. Am. J. Respir. Cell Mol. Biol. 6: 315-325, 1992.
14. Hart, C. M., S. P. Andreoli, C. E. Patterson, and J. G. N. Garcia. Oleic acid supplementation reduces oxidant-mediated dysfunction of cultured porcine pulmonary artery endothelial cells. J. Cell. Physiol. 156: 24-34, 1993.
15. Hevel, J. M., and M. A. Marletta. Nitric oxide synthase assays. Methods Enzymol. 233: 251-258, 1994.
16. Kornberg, L., H. S. Earp, J. T. Parsons, M. Schaller, and R. L. Juliano. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J. Biol. Chem. 267: 23439-23442, 1992.
17. Kubes, P., and D. N. Granger. Nitric oxide modulates microvascular permeability. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H611-H615, 1992.
18. Kurose, I., P. Kubes, R. Wolf, D. C. Anderson, J. Paulson, M. Miyasaka, and D. N. Granger. Inhibition of nitric oxide production. Circ. Res. 73: 164-171, 1993.
19. Lum, H., and A. B. Malik. Regulation of vascular endothelial barrier function. Am. J. Physiol. 267 (Lung Cell. Mol. Physiol. 11): L223-L241, 1994.
20. Minnear, F. L., M. A. DeMichele, D. G. Moon, C. L. Rieder, and J. W. Fenton. Isoproterenol reduces thrombin-induced pulmonary endothelial permeability in vitro. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1613-H1623, 1989.
21. Moy, A. B., J. V. Engelenhoven, J. Bodmer, J. Kamath, C. Keese, I. Giaever, S. Shasby, and D. M. Shasby. Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces. J. Clin. Invest. 97: 1020-1027, 1996.
22. Moy, A. B., S. S. Shasby, B. D. Scott, and D. M. Shasby. The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells. J. Clin. Invest. 92: 1198-1206, 1993.
23. Mulkey, R. M., S. Endo, S. Shenolikar, and R. C. Malenka. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature 369: 486-488, 1994.
24. Nakanishi, S., K. Yamada, K. Iwahashi, K. Kuroda, and H. Kase. KT5926, a potent and selective inhibitor of myosin light chain kinase. Mol. Pharmacol. 37: 482-488, 1990.
25. 2+-independent mechanism. J. Biol. Chem. 270: 1057-1061, 1995.
26. Patterson, C. E., H. Davis, K. Schaphorst, and J. G. N. Garcia. Mechanisms of cholera toxin prevention of thrombin-and PMA-induced endothelial cell barrier dysfunction. Microvasc. Res. 48: 212-235, 1994.
27. Patterson, C. E., R. A. Rhoades, and J. G. N. Garcia. Evans blue-albumin binding as a new marker of transendothelial macromolecule permeability. J. Appl. Physiol. 72: 865-873, 1992.
28. Patterson, C. E., J. E. Stasek, K. L. Schaphorst, H. W. Davis, and J. G. N. Garcia. Mechanisms of pertussis toxin-induced barrier dysfunction in bovine pulmonary artery endothelial cell monolayers. Am. J. Physiol. 268 (Lung Cell. Mol. Physiol. 12): L926-L934, 1995.
29. Pumiglia, K. M., and M. B. Feinstein. Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Biochem. J. 294: 253-260, 1993.
30. 2+] determines myosin phosphorylation in agonist-stimulated swine arterial smooth muscle. Circ. Res. 63: 593-603, 1988.
31. Romer, L. H., N. McLean, C. E. Turner, and K. Burridge. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol. Biol. Cell 5: 349-361, 1994.
32. Schaphorst, K. L., F. M. Pavalko, C. E. Patterson, and J. G. N. Garcia. Thrombin-mediated focal adhesion plaque reorganization in endothelium: role of protein phosphorylation. Am. J. Respir. Cell Mol. Biol. In press.
33. Schnittler, H. J., A. Wilke, T. Gress, N. Suttorp, and D. Drenckhahn. Role of actin and myosin in the control of paracellular permeability in pig, rat, and human vascular endothelium. J. Physiol. (Lond.) 431: 379-401, 1990.
34. Shasby, D. M., J. M. Kamath, A. B. Moy, and S. S. Shasby. Ionomycin and PDBU increase MDCK monolayer permeability independently of myosin light chain phosphorylation. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L144-L150, 1995.
35. Shasby, D. M., S. E. Lind, S. S. Shasby, J. C. Goldsmith, and G. W. Hunninghake. Reversible oxidant-induced increases in albumin transfer across cultured endothelium: alterations in cell shape and calcium homeostasis. Blood 65: 605-614, 1985.
36. Shasby, D. M., S. S. Shasby, J. M. Sullivan, and M. J. Peach. Role of endothelial cell cytoskeleton in control of endothelial permeability. Circ. Res. 51: 657-661, 1982.
37. Stasek, J. E., C. E. Patterson, and J. G. N. Garcia. Protein kinase C phosphorylates caldesmon 77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers. J. Cell. Physiol. 153: 62-75, 1992.
38. Stelzner, T. J., J. V. Weil, and R. F. O'Brien. Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties. J. Cell. Physiol. 139: 157-166, 1989.
39. 2+-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function. Proc. Natl. Acad. Sci. USA 92: 2696-2700, 1995.
40. Suttorp, N., U. Weber, T. Welsch, and C. Schudt. Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J. Clin. Invest. 91: 1421-1428, 1993.
41. Tiruppathi, C., A. B. Malik, P. J. Del Vecchio, C. R. Keese, and I. Giaever. Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Proc. Natl. Acad. Sci. USA 89: 7919-7923, 1992.
42. Verin, A., C. E. Patterson, M. E. Day, and J. G. N. Garcia. Regulation of endothelial cell gap formation and barrier function by myosin-associated phosphatase activities. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L99-L108, 1995.
43. Westendorp, R. G. J., R. Draijer, A. E. Meinders, and V. W. M. van Hinsbergh. Cyclic GMP-mediated decrease in permeability of human umbilical and pulmonary artery endothelial cell monolayers. J. Vasc. Res. 31: 42-51, 1994.
44. Wysolmerski, R. B., and D. Lagunoff. Regulation of permeabilized endothelial cell retraction by myosin phosphorylation. Am. J. Physiol. 261 (Cell Physiol. 30): C32-C40, 1991.
45. Wysolmerski, R. B., and D. Lagunoff. Involvement of myosin light chain kinase in endothelial cell retraction. Proc. Natl. Acad. Sci. USA 87: 16-20, 1990.
46. Yonemaru, M., K. Ishii, F. Murad, and T. A. Baffin. Atriopeptin-induced increases in endothelial cell permeability are associated with elevated cGMP levels. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L363-L369, 1992.