NF-κB signaling pathway as a target for human tumor radiosensitization

Seminars in Radiation Oncology

Volumn 11, Issue 4, 2001, Pages 346-351

  Jung, Mira ^a   Dritschilo, Anatoly ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CANCER; CANCER RADIOTHERAPY; CANCER SURVIVAL; GENE EXPRESSION REGULATION; HUMAN; IONIZING RADIATION; PRIORITY JOURNAL; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; STRESS;

EID: 0034788759     PISSN: 10534296     EISSN: None     Source Type: Journal    
DOI: 10.1053/srao.2001.26034     Document Type: Article

References (62)

1. Biological consequences of gene regulation after ionizing radiation exposure
2. Signal transduction and cellular responses to ionizing radiation
3. Ionizing radiation regulates expression of the c-jun protooncogene
4. Effect of antisense c-raf-1 on tumorigenicity and radiation sensitivity of a human squamous carcinoma
5. Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy
6. Radiation-induced proliferation of the human A431 squamous carcinoma cells dependent on EGFR tyrosine phsohporylation
7. Ionizing radiation induces expression and binding activity of the nuclear factor kappa B
8. Correction of radiation sensitivity in ataxia telangiectasia cells by a truncated IκB-α
9. Activation of NF-κB requires proteolysis of the inhibitor IκB: Signal-induced phosphorylation of IκB alone does not release active NFκB
10. Phosphorylation of IκB precedes but is not sufficient for its dissociation from NF-κB
11. Stimulation- dependent I kappa B alpha phosphorylation marks the NFkappa B inhibitor for degradation via the ubiquitin-proteasome pathway
12. The NF-κB and IκB proteins: New discoverles and insights
13. Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappa B activation
14. Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B- alpha
15. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
16. RE1/NF-κB/IκB story
17. Structure, regulation and function of NF-κB
18. I kappa B proteins: Structure, function and regulation
19. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
20. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
21. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NT-κB activation
22. Identification and characterization of an IκB kinase
23. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
24. The NF-κB activation pathway: A paradigm in information transfer from membrane to nucleus
25. IKKα is an essential regulatory subunit of the IβB kinase complex
26. IKKε as part of a novel PMA-inducible IκB kinase complex
27. IKAP is a scaffold protein of the I kappa B kinase complex
28. All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex
29. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation
30. NF-κB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
31. Molecular determinants of NF-kappaB-inducing kinase action
32. JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?
33. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
34. Coordinate regulation of IkappaB kinases by mitogen- activated protein kinase kinase kinase and NF-kappaB-inducing kinase
35. MEKK1 activates both IkappaB kinase alpha and Ikappa B kinase beta
36. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpba and IkappaB kinase-beta
37. The protooncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases
38. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
39. Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation
40. The transcription factor NF-κB: Control of oncogenesis and cancer therapy resistance
41. An essential role for NF-κB in preventing TNT-a-induced cell death
42. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
43. Suppression of TNF-a-induced apoptosis by NF-κB
44. NT-κB is activated and promotes cell death in focal cerebral ischemia
45. Impaired regulation of nuclear factor-κB results in apoptosis induced by gamma radiation
46. Expression of a dominant negative IκB-α modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis
47. Genetic approaches in mice to understand Rel/NF-κB and IκB function: Transgenics and knockouts
48. Embryonic lethality and liver degerneration in mice lacking the RelA component of NF-κB
49. NF-κB defects in humans: The NEMO/incontinentia pigmenti connection
50. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer
51. Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-κB in breast cancer
52. NF-κB as a primary, regulator of the stress response
53. A novel ionizing radiation-induced signaling pathway that activates the transcription factor NT-κB
54. ATM is required for IκB kinase (IKK) activation in response to DNA double strand breaks
55. Radiosensitivity and transcription factor NF-κB inhibition - Progress and pitfalls
56. Inhibition of NF-κB, clonogenicity, and radiosensitivitv of human cancer cells
57. Enhancement of radiosensitivity by proteasome inhibition: Implications for a role of NF-κB
58. The proteasome: A molecular target for cancer therapy
59. Apoptosis and radiosensitization of Hodgkin cells by proteasome inhibition
60. Inhibition of IkappaB-alpha phosphorylation at serine and tyrosine acts independently on sensitization to DNA damaging agents in human glioma cells
61. The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemic lymphocytes to TNF-alpha-initiated apoptosis
62. Enhanced radio-sensitivity by inhibition of nuclear factor kappa B activation in human malignant glioma cells