Expression of a dominant negative IκB-α modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis

Radiation Oncology Investigations

Volumn 5, Issue 6, 1997, Pages 265-268

  Jung, Mira ^a,b   Zhang, Yin ^a   Dritschilo, Anatoly ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b Division of Radiation Research   (United States)

Author keywords

Apoptosis; Ataxia telangiectasia; Radiomimetic drugs; Streptonigrin

Indexed keywords

ACTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; REGULATOR PROTEIN; RUFOCROMOMYCIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CELL SURVIVAL; CONTROLLED STUDY; FIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; X RAY;

APOPTOSIS; ATAXIA TELANGIECTASIA; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DRUG RESISTANCE; FIBROBLASTS; HUMANS; I-KAPPA B PROTEINS; NF-KAPPA B; PHENOTYPE; STREPTONIGRIN;

EID: 0031459008     PISSN: 10657541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6823(1997)5:6<265::AID-ROI1>3.0.CO;2-W     Document Type: Article

References (24)

1. Hermann S: Mechanisms and genes of cellular suicide. Science 267:1445-1449, 1995.
2. Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462, 1995.
3. Uckun FM, Waddick KG, Mahajan S, Jun X, Takata M, Bolen J, Kurosaki T: BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells. Science 273:1096-1100, 1996.
4. Meyn MS, Strasfeld L, Allen C: Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia. Int J Radiat Biol 66:S141-S149, 1994.
5. Duchaud E, Ridet A, Stoppa-Lyonnet D, Janin N, Moustacchi E, Rosselli F: Deregulated apoptosis in ataxia telangiectasia: Association with clinical stigmata and radiosensitivity. Cancer Res 56:1400-1404, 1996.
6. Beg AA, Baltimore D: An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274: 782-784, 1997.
7. Wang CY, Mayo MW, Baldwin AS: TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB. Science 274:784-787, 1997.
8. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM: Suppression of TNF-α-induced apoptosis by NF-κB. Science 274:787-789, 1997.
9. Jung M, Zhang Y, Lee SA, Dritschilo A: Correction of radiation sensitivity in ataxia telangiectasia cells by a truncated IκB-α. Science 268:1619-1621, 1995.
10. Sen R, Baltimore D: Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46: 705-716, 1986.
11. Baeuerle PA, Baltimore D: IκB-α: A specific inhibitor of the NF-κB transcription factor. Science 242:540-546, 1988.
12. Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U: Control of IκB-α proteolysis by sitespecific, signal-induced phosphorylation. Science 267: 1485-1488, 1995.
13. Chen ZJ, Parent L, Maniatis T: Site-specific phosphorylation of IκB-α by a novel ubiquitination-dependent protein kinase activity. Cell 84:853-862, 1996.
14. Imbert V, Rupee RA, Livolsi A, Pahl HL, Traenckner E, Mueller-Dieckmanne, C, Farahifar D, Rossi B, Auberger P, Baeuerle PA, Peyron J: Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α. Cell 86:787-798, 1996.
15. Jung M, Zhang Y, Dimtchev A, Dritschilo A: Optimal NF-κB activation is required for protection of cells from apoptosis (manuscript submitted to Radiat. Res., 1997).
16. Taylor AMR, Byrd PJ, McConville CM, Thacker S: Genetic and cellular features of ataxia telangiectasia. Int J Radiat Biol 65:65-70, 1994.
17. McKinnon PJ: Ataxia telangiectasia: An inherited disorder of ionizing radiation sensitivity in man. Hum Genet 75:197-208, 1987.
18. Kastan MB, Zhan Q, EL Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell 71:587-597, 1992.
19. Khanna KK, Lavin MF: Ionizing radiation and UV induction of p53 protein by different pathways in ataxia telangiectasia cells. Oncogene 8:3307-3312, 1993.
20. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T: P53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847-849, 1993.
21. Vaux DL: Toward an understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad Sci USA 90:786-789, 1993.
22. Williams GT, Smith CA: Molecular regulation of apoptosis: Genetic controls on cell death. Cell 74:777-779, 1993.
23. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB: bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608, 1993.
24. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619, 1993.