Increased expression of low-affinity insulin receptor isoform and insulin/insulin-like growth factor-1 hybrid receptors in term placenta from insulin-resistant women with gestational hypertension

Diabetologia

Volumn 39, Issue 8, 1996, Pages 952-960

  Valensise, H ^a   Liu, Y Y ^b   Federici, M ^b   Lauro, D ^b   Dell'anna, D ^a   Romanini, C ^a   Sesti, G ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Gestational hypertension; Hybrid receptor; IGF I receptor; Insulin receptor; Insulin resistance; Placenta

Indexed keywords

INSULIN RECEPTOR; SOMATOMEDIN C RECEPTOR;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYPERINSULINEMIA; INSULIN BINDING; INSULIN RESISTANCE; MATERNAL HYPERTENSION; PLACENTA; PRIORITY JOURNAL; RECEPTOR AFFINITY;

EID: 0029888364     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00403915     Document Type: Article

References (49)

1. Bauman WA, Maimen M, Langer O (1988) An association between hyperinsulinemia and hypertension during the third trimester of pregnancy. Am J Obstet Gynecol 159: 27-31
2. National High Blood Pressure Education Working Group (1990) High blood pressure during pregnancies. Am J Obstet Gynecol 163: 1689-1712
3. Evain-Brion D (1994) Hormonal regulation of fetal growth. Horm Res 42: 207-214
4. Reece EA, Wiznitzer A, Le E, Homko CJ, Behrman H, Spencer EM (1994) The relation between human fetal growth and fetal blood levels of insulin-like growth factors I and II, their binding proteins, and receptors. Obstet Gynecol 84: 88-95
5. Nelson DM, Smith RM, Jarret L (1978) Non-uniform distribution and grouping of insulin receptors on the surface of human syncytial trophoblast. Diabetes 27: 530-538
6. Desoye G, Hofmann HH, Weiss PAM (1992) Insulin binding to trophoblast plasma membranes and placental glycogen content in well-controlled gestational diabetic women treated with diet or insulin, in well-controlled overt diabetic patients and in healthy control subjects. Diabetologia 35: 45-55
7. Whitsett JA, Lessard JL (1978) Characteristic of the microvillous brush border of human placenta: insulin receptor localization in brush border membranes. Endocrinology 103: 1458-1468
8. Wolf HJ, Desoye G (1993) Immunohistochemical localization of glucose transporters and insulin receptors in human fetal membranes at term. Histochemistry 100: 379-385
9. Ullrich A, Gray A, Tam AW et al. (1986) Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 5: 2503-2512
10. Ullrich A, Bell JR, Chen EY et al. (1985) Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature (London) 313: 756-761
11. Ebina Y, Ellis L, Jarnagin K et al. (1985) The structural basis for hormone-activated transmembrane signalling. Cell 40: 747-758
12. Seino S, Seino M, Nishi S, Bell GI (1989) Structure of the human insulin receptor gene and characterization of its promoter. Proc Natl Acad Sci USA 86: 114-118
13. Seino S, Bell GI (1989) Alternative splicing of human insulin receptor messenger RNA. Biochem Biophys Res Comm 159: 312-316
14. Moller DE, Yokota A, Caro JF, Flier JE (1989) Tissue-specific expression of two alternative spiced insulin receptor mRNA in man. Mol Endocrinol 3: 1263-1269
15. Mosthaf L, Grako D, Dull TJ, Coussens L, Ullrich A, Mc Clain DA (1990) Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J 9: 2409-2413
16. Yamaguchi Y, Flier JS, Yokota A, Benecke H, Backer JM, Moller DE (1991) Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. Endocrinology 129: 2058-2066
17. Yamaguchi Y, Flier JS, Benecke H, Ransil BJ, Moller DE (1993) Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology 132: 1132-1138
18. Kellerer M, Lammers R, Ermel B et al. (1992) Distinct α-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities. Biochemistry 31: 4588-4596
19. McClain DA (1991) Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action. Mol Endocrinol 5: 734-739
20. Vogt B, Carrascosa JM, Ermel B, Ullrich A, Haring HU (1991) The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics. Biochem Biophys Res Comm 177: 1013-1018
21. Sesti G, Marini MA, Montemurro A et al. (1992) Evidence that two naturally occurring human insulin receptor α-subunit variants are immunologically distinct. Diabetes 41: 6-11
22. Sesti G, Tullio AN, Marini MA et al. (1994) Role of the exon 11 of the insulin receptor gene on insulin binding identified by anti-peptide antibodies. Mol Cell Endocrinol 101: 121-127
23. Mosthaf L, Vogt B, Haring HU, Ullrich A (1991) Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 88: 4728-4730
24. Sesti G, Marini MA, Tullio AN (1991) Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients. Biochem Biophys Res Comm 181: 1419-1424
25. Benecke H, Flier JS, Moller DE (1992) Alternatively spliced variants of the human insulin receptor protein. J Clin Invest 89: 2066-2070
26. Mosthaf L, Eriksson J, Haring HU, Groop L, Widen E, Ullrich A (1993) Insulin receptor isotypes expression correlates with risk of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 90: 2633-2635
27. Norgren S, Zierath J, Galuska D, Wallberg-Henriksson H, Luthman H (1993) Differences in the ratio of RNA encoding two isoforms of the insulin receptor between control and NIDDM patients. Diabetes 42: 675-681
28. Anderson CM, Henry RR, Knudson PE, Olesky JM, Webster NJG (1993) Relative expression of insulin receptor isoforms does not differ in lean, obese, and noninsulin-dependent diabetes mellitus subjects. J Clin Endocrinol Metab 72: 1380-1383
29. Hansen T, Bjorbaek C, Vestergaard H, Gronskov K, Bak JF, Pedersen O (1993) Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 77: 1500-1505
30. Kellerer M, Sesti G, Seffer E et al. (1993) Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (non-insulin-dependent) diabetic subjects. Diabetologia 36: 628-632
31. Sesti G, D'Alfonso R, Vargas Punti MD et al. (1995) Peptide-based radioimmunoassay for the two isoforms of the human insulin receptor. Diabetologia 38: 445-453
32. Soos MA, Siddle K (1989) Immunological relationships between receptors for insulin and insulin-like growth factor-I. Biochem J 263: 553-563
33. Moxham CP, Duronio V, Jacobs S (1989) Insulin-like growth factor-I receptors β-subunit heterogeneity. J Biol Chem 264: 13 238-13 244
34. Treadway JL, Morrison BD, Goldfine ID, Pessin JE (1989) Assembly of insulin/insulin-like growth factor-I hybrid receptors in vitro. J Biol Chem 264: 21 450-21 453
35. Soos MA, Whittaker J, Lammers R, Ullrich A, Siddle K (1990) Receptor for insulin and insulin-like growth factor-I can form hybrid dimers. Biochem J 270: 383-390
36. Frattali AL, Pessin JE (1993) Relationship between α subunit ligand occupancy and β subunit autophosphorylation and insulin/insulin-like growth factor-I hybrid receptors. J Biol Chem 268: 7393-7400
37. Soos MA, Field CE, Siddle K (1993) Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem J 290: 419-426
38. Langlois WJ, Sasaoka T, Yip CC, Olefsky JM (1995) Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptor. Endocrinology 136: 1978-1986
39. Seely BL, Reichart DR, Takata Y, Yip CC, Olefsky JM (1995) A functional assessment of insulin/insulin-like growth factor-I hybrid receptors. Endocrinology 136: 1635-1641
40. Meekins JV, Pijnenborg R, Hanssens M, McFabjen IR, Van Asshe A (1994) A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies. Br J Obstet Gynaecol 101: 669-674
41. 125I monoiodoinsulin purified by different high-performance liquid Chromatographic procedures and by polyacrilamide gel electrophoresis: preparation, immunochemical properties and receptor binding affinity. J Chromatogr 378: 337-347
42. Davey DA, MacGillivray I (1988) The classification and definition of hypertensive disorders of pregnancy. Am J Obstet Gynecol 158: 892-898
43. Sesti G, Tullio AN, D'Alfonso R et al. (1994) Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein. Acta Diabetologica 31: 59-65
44. Harrison LC, Billington T, East IJ, Nichols RJ, Clark S (1978) The effect of solubilization on the properties of the insulin receptor of human placental membranes. Endocrinology 102: 1484-1495
45. Bradford MM (1978) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
46. Norgren S, Zierath J, Wedell A, Wallberg-Henriksson H, Luthman H (1994) Regulation of human insulin receptor RNA splicing in vivo. Proc Natl Acad Sci USA 91: 1465-1469
47. Kosaki A, Webster NJG (1993) Effect of dexamethasone of the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepaloma cells. J Biol Chem 268: 21 990-21 996
48. Norgren S, Sheng Li L, Luthman H (1994) Regulation of human insulin receptor RNA splicing in HepG2 cells: effects of glucocorticoid and low glucose concentration. Biochem Biophys Res Comm 199: 277-284
49. Sell SM, Reese D, Ossowski VM (1994) Insulin-inducible changes in insulin receptor mRNA splice variants. J Biol Chem 269: 30 769-30 772