Increased expression of insulin/insulin-like growth factor-1 hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects

Journal of Clinical Investigation

Volumn 98, Issue 12, 1996, Pages 2887-2893

  Federici, Massimo ^a   Zucaro, Luigi ^a   Porzio, Ottavia ^a   Massoud, Renato ^b,c   Borboni, Patrizia ^a   Lauro, Davide ^a   Sesti, Giorgio ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

Hybrid receptor; IGF I receptor; Insulin receptor; Insulin resistance

Indexed keywords

HYBRID PROTEIN; INSULIN I 125; INSULIN RECEPTOR; SOMATOMEDIN C I 125; SOMATOMEDIN C RECEPTOR;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; INSULIN BINDING; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULINEMIA; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RECTUS ABDOMINIS MUSCLE; SKELETAL MUSCLE;

BINDING, COMPETITIVE; BLOTTING, WESTERN; DIABETES MELLITUS, TYPE 2; HUMANS; IMMUNOASSAY; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; MUSCLE, SKELETAL; PROTEIN CONFORMATION; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN;

EID: 0030453978     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119117     Document Type: Article

References (32)

1. De Fronzo, R.A. 1988. The triumvirate: β-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes. 37:667-687.
2. De Fronzo, R.A., R. Gunnarsson, O. Bjorkman, M. Olsson, and J. Wahren. 1985. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin dependent (type II) diabetes mellilus. J. Clin. Invest. 76: 149-155.
3. Cheatham, B., and C.R. Kahn. 1995. Insulin action and the insulin signaling network. Endocr. Rev. 16:117-142.
4. Ullrich, A., R.J. Bell, E.Y. Chen, R. Herrera, L.M. Petruzzelli, T.J. Dull, A. Gray, L. Coussens, Y.C Liao, M. Tsubokawa, et al. 1985. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature (Lond.). 313:756-761.
5. Ebina, Y., L. Ellis, K. Jarnagin, M. Edery, L. Graf, E. Clauser, J.H. Ou, F. Masiarz, Y.W. Kan, I.D. Goldfine, et al. 1985. The structural basis for hormone-activated transmembrane signalling. Cell. 40:747-758.
6. Ullrich, A., A. Gray, A.W. Tam, T. Yang-Feng, M. Tsubokawa, C. Collins, W. Henzel, T. Le Bon, S. Kathuria, E. Chen, S. Jacobs, et al. 1986. Insulin-like growth factor I receptor primary structure: comparision with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5:2503-2512.
7. Soos, M.A., and K. Siddle. 1989. Immunological relationships between receptors for insulin and insulin-like growth factor-I. Biochem. J. 263:553-563.
8. Moxham, C.P., V. Duronio, and S. Jacobs. 1989. Insulin-like growth factor-I receptors β-subunit heterogeneity. J. Biol. Chem. 264:13238-13244.
9. Soos, M.A., J. Whittaker, R. Lammers, A. Ullrich, and K. Siddle. 1990. Receptor for insulin and insulin-like growth factor-I can form hybrid dimers. Biochem. J. 270:383-390.
10. Treadway, J.L., B.D. Morrison, I.D. Goldfine, and J.E. Pessin. 1989. Assembly of insulin/insulin-like growth factor-I hybrid receptors in vitro. J. Biol. Chem. 264:21450-21453.
11. Soos, M.A., C.E. Field, and K. Siddle. 1993. Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem. J. 290:419-426.
12. Langlois, W.J., T. Sasaoka, C.C. Yip, and J.M. Olefsky. 1995. Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptor. Endocrinology. 136:1978-1986.
13. Frattali, A.L., and J.E. Pessin. 1993. Relationship between a subunit ligand occupancy and β subunit autophosphorylation in insulin/insulin-like growth factor-I hybrid receptors. J. Biol. Chem. 268:7393-7400.
14. Seely, B.L., D.R. Reichart, Y. Takata, C.C. Yip, and J.M. Olefsky. 1995. A functional assessment of insulin/Insulin-like Growth Factor-I hybrid receptors. Endocrinology. 136:1635-1641.
15. National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
16. Bonora, E., P. Moghetti, C. Zancanaro, M. Cigolini, M. Querena, V. Cacciatori, A. Corgnati, and M. Muggeo. 1989. Estimates of in vivo insulin action in man: comparision of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J. Clin. Endocrinol. Metab. 68:374-378.
17. Sesti, G., R. D'Alfonso, M.D. Vargas Punti, L. Frittitta, V. Trischitta, Y.Y. Liu, P. Borboni, R. Longhi, A. Montemurro, and R. Lauro. 1995. Peptide-based radioimmunoassay for the two isoforms of the human insulin receptor. Diabetologia. 38:445-453.
18. Forsayeth, J.R., A. Montemurro, B.A. Maddux, R. De Pirro, and I.D. Goldfine. 1987. Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation. J. Biol. Chem. 262:4134-4140.
19. 125I monoiodoinsulin purified by different high-performance liquid chromatographic procedures and by polyacrylamide gel electrophoresis: preparation, immunochemical properties and receptor binding affinity. J. Chromatogr. 378:337-347.
20. Bradford, M.M. 1978. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
21. Scatchard, G. 1949. The attraction of proteins for small molecules and ions. Ann. NY Acad. Sci. 51:660-675.
22. Rosenzweig, S.A., C. Zelterstrom, and A. Benjamin. 1990. Identification of retinal insulin receptor using site-specific antibodies to a carboxyl-terminal peptide of the human insulin receptor α-subunit. J. Biol. Chem. 265:18030-18034.
23. Caro, J.F., M.K. Shina, S.M. Raju, O. Ittoop, W. J. Porics, E.G. Flickinger, D. Meelheim, and G.L. Dohm. 1987. Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. J. Clin. Invest. 79:1330-1337.
24. Arner, P., T. Pollare, H. Lithell, and J.N. Livingston. 1987. Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetolagia. 30:437-440.
25. James, D.E., A. Zorzano, M. Boni-Schnetzler, R.A. Nemenoff, A. Powers, P.F. Pilch, and N.B. Ruderman. 1986. Intrinsic differences of insulin receptor kinase activity in red and white muscle. J. Biol. Chem. 261:14939-14944.
26. Obermaier-Kusser, B., M.F. White, D.E. Pongratz, Z. Su, B. Ermel, C. Munhlbacher, and H.U. Haring. 1989. A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus. J. Biol. Chem. 264:9497-9504.
27. Garvey, W.T., L. Maianu, J.A. Hancock, A.M. Golichowski, and A. Baron. 1992. Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM. Diabetes. 41:465-475.
28. Andersen, P.H., S. Lund, H. Vestergaard, S. Junker, B.B. Kahn, and O. Pedersen. 1993. Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion. J. Clin. Endocrinol. Metab. 77:27-32.
29. Kolaczynski, J.M., and J.F. Caro. 1994. Insulin-like growth factor-I therapy in diabetes: physiological basis, clinical benefits, and risks. Ann. Int. Med. 120:47-55.
30. Zenobi, P.D., S.E. Jaeggi-Groisman, W.F. Riesen, M.E. Roder, and E.R. Froesch. 1992. Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes. J. Clin. Invest. 90:2234-2241.
31. Hussain, M.A., O. Schmitz, A. Mengel, A. Keller, J.S. Christiansen, J. Zapf, and E.R. Froesch. 1993. Insulin-like growth factor-I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans. J. Clin. Invest. 92:2249-2256.
32. Moses, A.C., S.C.J. Young, L.A. Morrow, M. O'Brien, and D.R. Clemmons. 1996. Recombinant human insulin-like-growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes. Diabetes. 45:91-100.