Mechanisms of agonist-induced down-regulation of the human κ-opioid receptor: Internalization is required for down-regulation

Molecular Pharmacology

Volumn 58, Issue 4, 2000, Pages 795-801

  Li, Jian Guo ^a   Benovic, Jeffrey L ^b   Liu Chen, Lee Yuan ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; ALOXISTATIN ACID; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHLOROQUINE; DIPRENORPHINE; ETORPHINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; LACTACYSTIN; PROTEASOME INHIBITOR; SULFUR 35; TRITIUM;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME INHIBITION; GENE EXPRESSION; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

EID: 0033798515     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.4.795     Document Type: Article

References (56)

1. Characterization of κ opiate receptors in rat spinal cord-dorsal root ganglion cocultures and their regulation by chronic opiate treatment
2. 2-adrenergic receptor sequestration
3. Beta-adrenergic receptor kinase: Primary structure delineates a multigene family
4. Effect of chronic administration of U-50,488H on tolerance to its pharmacological actions and on multiple opioid receptors in rat brain regions and spinal cord
5. Differential agonist regulation of the human kappa-opioid receptor
6. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
7. Mutations of the human β2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration
8. From ligand binding to gene expression: New insights into the regulation of G protein-coupled receptors
9. Thr353, located within the COOH-terminal tail of the delta opiate receptor, is involved in receptor downy regulation
10. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
11. Kappa opioids in Rhesus monkeys. I. Diuresis, sedation, analgesia and discriminative stimulus effects
12. Cloning of a delta opioid receptor by functional expression
13. Rab 7: An important regulator of late endocytic membrane traffic
14. Role of clathrin-mediated endocytosis in agonist-induced down-regulation of the beta2-adrenergic receptor
15. Differential role of the carboxyl-terminal tyrosine in down-regulation and sequestration of the m2 muscarinic acetylcholine receptor
16. Turning off the signal: Desensitization of β-adrenergic receptor function [published erratum appears in FASEB J 1990;4:3049]
17. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor
18. Gettin' down with ubiquitin: Turning off cell-surface receptors, transporters and channels
19. Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors
20. Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway
21. Kappa opioid receptor tolerance in the guinea pig hippocampus
22. β2-Adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis
23. The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure
24. Visualization of agonist-induced sequestration and down-regulation of a green fluorescent protein-tagged beta(2)-adrenergic receptor
25. The δ-opioid receptor: Isolation of a eDNA by expression cloning and pharmacological characterization [published erratum appears in Proc Natl Acad Sci USA 1994;91:1193]
26. Molecular biology and pharmacology of cloned opioid receptors
27. Visualization of time-dependent redistribution of delta-opioid receptors in neuronal cells during prolonged agonist exposure
28. 2 -adrenergic receptor
29. The role of receptor kinases and arrestins in G protein-coupled receptor regulation
30. Modulation of the arrestin-clathrin interaction in cells - Characterization of beta-arrestin dominant-negative mutants
31. Down-regulation of opiate receptor in neuroblastoma x glioma NH108-15 hybrid cells: Chloroquine promotes accumulation of tritiated enkephalin in the lysosomes
32. Effect of pertussis toxin treatment on down-regulation of opiate receptors in neuroblastoma x glioma NG108-15 hybrid cells
33. U50,488H-induced internalization of the human κ opioid receptor involves a β-arrestin- and dynamin-dependent mechanism: κ Receptor internalization is not required for MAP kinase activation
34. Molecular cloning and expression of a rat κ opioid receptor
35. β -Arrestin: A protein that regulates beta-adrenergic receptor function
36. Anatomy of CNS opioid receptors
37. A practical computer based approach to the analysis of radioligand binding experiments
38. The rab7 GTPase resides on a vesicular compartment connected to lysosomes
39. Ligand-stimulated beta 2-adrenergic receptor internalization via the constitutive endocytic pathway into rab5-containing endosomes
40. Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway
41. Control of opiate receptor number in vivo: Simultaneous κ-receptor down-regulation and μ-receptor up-regulation following chronic agonist/antagonist treatment
42. Role of Rab GTPases in membrane traffic
43. Psychotomimesis mediated by kappa opiate receptors
44. G protein-coupled receptor (GPCR) trafficking in the central nervous system: Relevance for drugs of abuse
45. Rab proteins and the road maps for intracellular transport
46. Measurement of protein using bicinchoninic acid
47. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis
48. Sequestration of the delta opioid receptor - Role of the C terminus in agonist-mediated internalization
49. Mutations in human dynamin block an intermediate stage in coated vesicle formation
50. Role of the small GTPase Rab7 in the late endocytic pathway
51. U-50,488: A selective and structurally novel non-μ (κ) opioid agonist
52. Cloning of a human κ opioid receptor from the brain
53. 35 S]GTPγ S binding to membranes: Determination of potencies and efficacies of ligands
54. Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in CHO cells