Despite sabstantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor-dependent g-protein activation in rat cerebellar membranes

British Journal of Pharmacology

Volumn 134, Issue 3, 2001, Pages 664-672

  Savinainen, Juha R ^a   Järvinen, Tomi ^a   Laine, Krista ^a   Laitinen, Jarmo T ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

2 arachidonoylglycerol; Anandamide; Cannabinoid; Cannabinoid receptor; Endocannabinoid; Noladin ether

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2 ISOPROPOXYETHYL ETHER; 2 O ARACHIDONOYLGLYCERYL ETHER; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ANANDAMIDE; BENZYLSULFONYL FLUORIDE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; G PROTEIN COUPLED RECEPTOR; HU 310; HU 313; METHANANDAMIDE; UNCLASSIFIED DRUG; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ARACHIDONIC ACID DERIVATIVE; CANNABINOID RECEPTOR; DRUG RECEPTOR; ENDOCANNABINOID; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CEREBELLUM; CONTROLLED STUDY; DEGRADATION; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; WISTAR RAT;

ANIMALS; ARACHIDONIC ACIDS; CANNABINOIDS; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCANNABINOIDS; GLYCERIDES; GTP-BINDING PROTEINS; MALE; NEUROTRANSMITTER AGENTS; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0034740567     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704297     Document Type: Article

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