Regulation of Fas-Mediated Apoptosis

Current Topics in Cellular Regulation

Volumn 35, Issue C, 1997, Pages 69-105

  Gottlieb, Roberta A ^a   Babior, Bernard M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; FASLG PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN BCL 2; PROTEINASE;

AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; GENETICS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; PHYSIOLOGY; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; ENDOPEPTIDASES; FAS LIGAND PROTEIN; HUMANS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0030624030     PISSN: 00702137     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0070-2137(97)80003-9     Document Type: Chapter

References (216)

1. Aggarwal B.B., Singh S., LaPushin R., and Totpal K. Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor. FEBS Lett. 364 (1995) 5-8
2. Alderson M.R., Tough T.W., Davis-Smith T., Braddy S., Falk B., Schooley K.A., Goodwin R.G., Smith C.A., Ramsdell F., and Lynch D.H. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181 (1995) 71-77
3. Alnemri E.S., Fernandes-Alnemri T., and Litwack G. Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities. J. Biol. Chem. 270 (1995) 4312-4317
4. Anel A., Buferne M., Boyer C., Schmitt-Verhulst A.M., and Golstein P. T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A. Eur. J. Immunol. 24 (1994) 2469-2476
5. Arase H., Arase N., and Saito T. Fas-mediated cytotoxicity by freshly isolated natural killer cells. J. Exp. Med. 181 (1995) 1235-1238
6. Bargou R.C., Bommert K., Weinmann P., Daniel P.T., Wagener C., Mapara M.Y., and Dorken B. Induction of Bax-alpha precedes apoptosis in a human B lymphoma cell line: Potential role of the bcl-2 gene family in surface IgM-mediated apoptosis. Eur. J. Immunol. 25 (1995) 770-775
7. Behrmann I., Walczak H., and Krammer P.H. Structure of the human APO-1 gene. Eur. J. Immunol. 24 (1994) 3057-3062
8. Belgrau D., Gold D., Selawry H., Moore J.J., Franzusoff A., and Duke R.C. A role for CD95 ligand in preventing graft rejection. Nature (London) 377 (1995) 630-632
9. Benito A., Grillot D., Nunez G., and Fernandez-Luna J.L. Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells. Am J Pathol. 146 (1995) 481-490
10. Berke G. The CTL's kiss of death (review). Cell (Cambridge, Mass.) 81 (1995) 9-12
11. Bielawska A., Crane H.M., Liotta D., Obeid L.M., and Hannun Y.A. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J. Biol. Chem. 268 (1993) 26226-26232
12. Birnbaum M.J., Clem R.J., and Miller L.K. An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs. J. Virol. 68 (1994) 2521-2528
13. Boise L.H., Gonzalez-Garcia M., Postema C.E., et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (Cambridge, Mass.) 74 (1993) 597-608
14. Boldin M.P., Varfolomeev E.E., Pancer Z., Mett I.L., Camonis J.H., and Wallach D. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem. 270 (1995) 7795
15. Boldin M.P., Mett I.L., and Wallach D. A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its "death domain". FEBS Lett. 367 (1995) 39-44
16. Boldin M.P., Goncharov T.M., Goltsev Y.V., and Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell (Cambridge, Mass.) 85 (1996) 803-815
17. Boudreau N., Sympson C.J., Werb Z., and Bissell M.J. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267 (1995) 891-893
18. Brunner T., Mogil R.J., LaFace D., Yoo N.J., Mahboubi A., Echeverri F., Martin S.J., Force W.R., Lynch D.H., Ware C.F., and Green D.R. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas (see comments). Nature (London) 373 (1995) 441-444
19. Bump N.J., Hackett M., Hugunin M., Seshagiri S., Brady K., Chen P., Ferenz C., Franklin S., Ghayur T., Li P., Licari P., Mankovich J., Shi L., Greenberg A.H., Miller L.K., and Wong W.W. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 269 (1995) 1885-1888
20. Carsetti R., Kohler G., and Lamers M.C. Transitional B cells are the target of negative selection in the B cell compartment. J. Exp. Med. 181 (1995) 2129-2140
21. Carson W.E., Haldar S., Baiocchi R.A., Croce C.M., and Caligiuri M.A. The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 7553-7557
22. Cartier J.L., Hersberger P.A., and Friesen P.D. Suppression of apoptosis in insect cells stably transfected with baculovirus p35: Dominant interference by N-terminal sequences p35(1-76). J. Virol. 68 (1994) 7728-7737
23. Cascino I., Fiucci G., Papoff G., and Ruberti G. Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. J. Immunol. 154 (1995) 2706-2713
24. Casciola-Rosen L.A., Miller D.K., Anhalt G.J., and Rosen A. Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic celldeath. J. Biol. Chem. 269 (1994) 30757-30760
25. Ceretti D.P., and Kozlosky C.J. Molecular cloning of the interleukin-1 beta converting enzyme. Science 256 (1992) 97-100
26. Chen M., Quintans J., Fuks Z., Thompson C., Kufe D.W., and Weichselbaum R.R. Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide. Cancer. Res. 55 (1995) 991-994
27. Chiarugi V., Magnelli L., Cinelli M., and Basi G. Apoptosis and the cell cycle (review). Cell. Mol. Biol. Res. 40 (1994) 603-612
28. Chinnaiyan A.M., O'Rourke K., Tewari M., and Dixit V.M. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell (Cambridge, Mass.) 81 (1995) 505-512
29. Chiu V.K., Walsh C.M., Liu C.C., Reed J.C., and Clark W.R. Bcl-2 blocks degranulation but not Fas-based cell-mediated cytotoxicity. J. Immunol. 154 (1995) 2023-2032
30. Chow S.C., Weis M., Kass G.E., Holmström T.H., Eriksson J.E., and Orrenius S. Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes. FEBS Lett. 364 (1995) 134-138
31. Chu J.L., Ramos P., Rosendorff A., Nikolic-Zugic E., Lacy E., Matsuzawa A., and Elkon K.B. Massive upregulation of the Fas ligand in lpr and gld mice: Implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. J. Exp. Med. 181 (1995) 393-398
32. Oct. 1. Churchill W.L.S. Speech (1939)
33. Cifone M.G., De Maria R., Roncaioli P., Rippo M.R., Azuma M., Lanier L.L., Santoni A., and Testi R. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J. Exp. Med. 180 (1994) 1547-1552
34. Clem R.J., and Miller L.K. Control of programmed cell death by the baculovirus genes p35 and iap. Mol. Cell. Biol. 14 (1994) 5212-5222
35. Cleveland J.L., and Ihle J.N. Contenders in FasL/TNF death signaling. Cell (Cambridge, Mass.) 81 (1995) 479-482
36. Cory S. Regulation of lymphocyte survival by the bcl-2 gene family (review). Annu. Rev. Immunol. 13 (1995) 513-543
37. D'Amico A.V., and McKenna W.G. Apoptosis and a re-investigation of the biologic basis for cancer therapy. Radiother. Oncol. 33 (1994) 3-10
38. Darmon A.J., Nicholson D.W., and Bleackley R.C. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature (London) 377 (1995) 446-448
39. Dawson C.W., Eliopoulos A.G., Dawson J., and Young L.S. BHRF1, a viral homologue of the Bcl-2 oncogene, disturbs epithelial cell differentiation. Oncogene 10 (1995) 69-77
40. Dawson S.P., Arnold J.E., Mayer N.J., Reynolds S.E., Billett M.A., Gordon C., Colleaux L., Kloetzel P.M., Tanaka K., and Mayer R.J. Developmental changes of the 26 S proteasome in abdominal intersegmental muscles of Manduca sexta during programmed cell death. J. Biol. Chem. 270 (1995) 1850-1858
41. Eischen C.M., Dick C.J., and Leibson P.J. Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis. J. Immunol. 153 (1994) 1947-1954
42. Ellis H.M., and Horvitz J.R. Genetic control of programmed cell death in the nematode C. elegans. Cell (Cambridge, Mass.) 44 (1986) 817-829
43. Enari M., Hug H., and Nagata S. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature (London) 375 (1995) 78-81
44. Fadok V.A., Savill J.S., Haslett C., Bratton D.L., Doherty D.E., Campbell P.A., and Henson P.M. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J. Immunol. 149 (1992) 4029-4035
45. L rescues WEHI 231 B lymphocytes from oxidantmediated death following diverse apoptotic stimuli. J. Immunol. 155 (1995) 66-75
46. Fang W., Rivard J.J., Mueller D., and Behrens T.W. Cloning and molecular characterization of mouse Bcl-x in B and T lymphocytes. J. Immunol. 153 (1994) 4388-4398
47. Faucheu C., Diu A., Chang A.W., Blanchet A.M., Miossec C., Herve F., Collard-Dutilleul V., Gu Y., Aldape R.A., Lippke J.A., et al. A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells. EMBO J. 14 (1995) 1914-1922
48. Fernandes-Alnemri T., Litwack G., and Alnemri E.S. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1beta-converting enzyme. J. Biol. Chem. 269 (1994) 30761-30764
49. Fernandes-Alnemri T., Litwack G., and Alnemri E.S. Mch2, a new member of the apoptotic Ced. 3/Ice cysteine protease gene family. Cancer Res. 55 (1995) 2737-2742
50. Franceschi C. Cell proliferation, cell death and dying (review). Aging 1 (1989) 3-15
51. Frisch S.M., and Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124 (1994) 619-626
52. Gagliardini V., Fernandez P.A., Lee R.K., Drexler H.C., Rotello R.J., Fishman M.C., and Yuan J. Prevention of vertebrate neuronal death by the crmA gene. Science 263 (1994) 826-828
53. Gillardon F., Eschenfelder C., Uhlmann E., Hartschuh W., and Zimmermann M. Differential regulation of c-fos, fosB, c-jun, junB, bcl-2 and bax expression in rat skin following single or chronic ultravioletirradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion. Oncogene 9 (1994) 3219-3225
54. Golstein P., Marguet D., and Depraetere V. Homology between reaper and the cell death domains of Fas and TNFR1 (letter). Cell (Cambridge, Mass.) 81 (1995) 185-186
55. Gompel A., Sabourin J.C., Martin A., Yaneva H., Audouin J., Decroix Y., and Poitout P. Bcl-2 expression in normal endometrium during the menstrual cycle. Am. J. Pathol. 144 (1994) 1195-1202
56. Gonzalez-Garcia M., Garcia I., Ding L., O'Shea S., Boise L.H., Thompson C.B., and Nunez G. Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 4304-4308
57. Gottlieb R.A., Burleson K.O., Kloner R.A., Babior B.M., and Engler R.L. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J. Clin. Invest. 94 (1994) 1621-1628
58. Gottschalk A.R., McShan C.L., Kilkus J., Dawson G., and Quintans J. Resistance to anti-IgM-induced apoptosis in a WEHI-231 subline is due to insufficient production of ceramide. Eur. J. Immunol. 25 (1995) 1032-1038
59. Gottschalk A.R., and Quintans J. Apoptosis in B lymphocytes: The WEHI-231 perspective (review). Immunol. Cell Biol. 73 (1995) 8-16
60. Green D.R., Mahboubi A., Nishioka W., Oja S., Echeverri F., Shi Y., Glynn J., Yang Y., Ashwell J., and Bissonnette R. Promotion and inhibition of activation-induced apoptosis in T-cell hybridomas by oncogenes and related signals (review). Immunol. Rev. 142 (1994) 321-342
61. Griffith T.S., Brunner T., Fletcher S.M., Green D.R., and Ferguson T.A. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270 (1995) 1189-1192
62. Grimm L., and Osborne B. Proteasome inhibition in thymocyte apoptosis. Abstr. Meet. Programmed Cell Death. 1995. Cold Spring Harbor Laboratory, New York (1995) 61
63. Gu Y., Sarnecki C., Aldape R.A., Livingston D.J., and Su M.S. Cleavage of poly(ATP-ribose)polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2. J. Biol. Chem. 270 (1995) 18715-18718
64. Gulbins E., Bissonnette R., Mahboubi A., Martin S., Nishioka W., Brunner T., Baier G., Baier-Bitterlich G., Byrd C., Lang F., et al. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity 2 (1995) 341-351
65. Haas A.L., Baboshina O., Williams B.M., and Schwartz L.M. Coordinated induction of the ubiquitin conjugation pathway accompanies the developmentally programmed death of insect skeletal muscle. J. Biol. Chem. 270 (1995) 9407-9412
66. Haimovitz-Friedman A., Kan C.C., Ehleiter D., Persaud R.S., McLoughlin M., Fuks Z., and Kolesnick R.N. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med. 180 (1994) 525-535
67. Haldar S., Beatty C., Tsujimoto Y., and Croce C.M. The bcl-2 gene encodes a novel G protein. Nature (London) 342 (1989) 195-198
68. Haldar S., Jena N., and Croce C.M. Inactivation of Bcl-2 by phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 4507-4511
69. Hanada M., Aime-Sempe C., Sato T., and Reed J.C. Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J. Biol. Chem. 270 (1995) 11962-11969
70. Hannun Y.A., and Obeid L.M. Ceramide: An intracellular signal for apoptosis (review). Trends Biochem. Sci. 20 (1995) 73-77
71. Hawkins C.J., and Vaux D.L. Analysis of the role of Bcl-2 in apoptosis (review). Immunol. Rev. 142 (1994) 127-139
72. Hay B.A., Wolff T., and Rubin G.M. Expression of baculovirus p35 prevents cell death in Drosophila. Development (Cambridge, UK) 120 (1994) 2121-2129
73. Henderson S., Huen D., Rowe M., Dawson C., Johnson G., and Rickinson A. Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 8479-8483
74. Hengartner M.O., Ellis R.E., and Horvitz H.R. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature (London) 356 (1992) 494-499
75. Hengartner M.O., and Horvitz H.R. Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2. Nature (London) 369 (1994) 318-320
76. Hengartner M.O., and Horvitz H.R. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell (Cambridge, Mass.) 76 (1994) 665-676
77. Hershberger P.A., LaCount D.J., and Friesen P.D. The apoptotic suppressor p35 is required early during baculovirus replication and is targeted to the cytosol of infected cells. J. Virol. 68 (1994) 3467-3477
78. Hockenbery D., Nunez G., Milliman C., Schreiber R.D., and Korsmeyer S.J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (London) 348 (1990) 334-336
79. Hockenbery D.M., Oltvai Z.N., Yin X.-M., Milliman C.L., and Korsmeyer S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (Cambridge, Mass.) 75 (1993) 241-251
80. Horvitz H.R. The ins and outs of programmed cell death during C. elegans development (review). Philos. Trans. R. Soc. London, B Ser. 345 (1994) 243-246
81. Howard A.D., Kostura M.J., Thornberry N., Ding G.J.F., Limjuco G., Weidner J., Salley J.P., Hogquist K.A., Chaplin D.D., Mumford R.A., Schmidt J.A., and Tocci M.J. IL-1 converting enzyme requires aspartic acid residues for processing of the IL-1β precursor at two distinct sites and does not cleave 31-kDaIL-1α. J. Immunol. 147 (1991) 2964-2969
82. Inazawa J., Itoh N., Abe T., and Nagata S. Assignment of the human Fas antigen gene (Fas) to 10q24.1. Genomics 14 (1992) 821-822
83. Irmler M., Hertig S., MacDonald H.R., Sadoul R., Becherer J.D., Proudfoot A., Solari R., and Tschopp J. Granzyme A is an interleukin 1 beta-converting enzyme. J. Exp. Med. 181 (1995) 1917-1922
84. Ito A., and Horigome K. Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation. J. Neurochem. 65 (1995) 463-466
85. Itoh N., and Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J. Biol. Chem. 268 (1993) 10932-10937
86. Itoh N., Tsujimoto Y., and Nagata S. Effect of bcl-2 on Fas antigenmediated cell death. J. Immunol. 151 (1993) 621-627
87. Itoh N., Yonehara S., Ishii A., Yonehara M., Mizushima S., Sameshima M., Hase A., Seto Y., and Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell (Cambridge. Mass.) 66 (1991) 233-243
88. Iwai K., Miyawaki T., Takizawa T., Konno A., Ohta K., Yachie A., Seki H., and Taniguchi N. Differential expression of bcl-2 and susceptibility to anti-Fasmediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils. Blood 84 (1994) 1201-1208
89. Jaattela M., Benedict M., Tewari M., Shayman J.A., and Dixit V.M. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene 10 (1995) 2297-2305
90. Jacobson M.D., and Raff M.C. Programmed cell death and Bcl-2 protection in very low oxygen. Nature (London) 374 (1995) 814-816
91. Jarvis W.D., Fornari Jr. F.A., Browning J.L., Gewirtz D.A., Kolesnick R.N., and Grant S. Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. J Biol. Chem. 269 (1994) 31685-31692
92. Jarvis W.D., Kolesnick R.N., Fornari F.A., Traylor R.S., Gewirtz D.A., and Grant S. Induction of apoptotic DNA damage and cell death by activation of the sphinogmyelin pathway. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 73-77
93. Jayadev S., Liu B., Bielawska A.E., Lee J.Y., Nazaire F., Pushkareva M.Yu., Obeid L.M., and Hannun Y.A. Role for ceramide in cell cycle arrest. J. Biol. Chem. 270 (1995) 2047-2052
94. Ji L., Zhang G., Uematsu S., Akahori Y., and Hirabayashi Y. Induction of apoptotic DNA fragmentation and cell death by natural ceramide. FEBS Lett. 358 (1995) 211-214
95. Ju S.T., Panka D.J., Cui H., Ettinger R., el-Khatib M., Sherr D.H., Stanger B.Z., and Marshak-Rothstein A. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation (see comments). Nature (London) 373 (1995) 444-448
96. Kamens J., Paskind M., Hugunin M., Talanian R.V., Allen H., Banach D., Bump N., Hackett M., Johnston C.G., Li P., et al. Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cystein proteases. J. Biol. Chem. 270 (1995) 15250-15256
97. Kamita S.G., Mijima K., and Maeda S. Identification and characterization of the p35 gene of Bombyx mori nuclear polyhedrosis virus that prevents virus-induced apoptosis. J. Virol. 67 (1993) 455-463
98. Kane D.J., Sarafian T.A., Anton R., Hahn H., Gralla E.B., Vallentine J.S., Ord T., and Bredesen D.E. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science 262 (1993) 1274-1277
99. Katsikis P.D., Wunderlich E.S., Smith C.A., Herzenberg L.A., and Herzenberg L.A. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J. Exp. Med. 181 (1995) 2029-2036
100. Kaufmann S.H., Desnoyers S., Ottaviano Y., Davidson N.E., and Poirier G.G. Specific proteolytic cleavage of poly(ADP-ribose)polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Res. 53 (1993) 3976-3985
101. Kaufmann S.H. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note. Cancer Res. 49 (1989) 5870-5878
102. Kerr J.F., Winterford C.M., and Harmon B.V. Apoptosis. Its significance in cancer and cancer therapy (review). Cancer (Philadelphia) 73 (1994) 2013-2026
103. Kiefer M.C., Brauer M.J., Powers V.C., Wu J.J., Umansky S.R., Tomei L.D., and Barr P.J. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature (London) 374 (1995) 736-739
104. Kinoshita T., Yokota T., Arai K., and Miyajima A. Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells. Oncogene 10 (1995) 2207-2212
105. Kiplesund K.M., Halgunset J., Fjosne H.E., and Sunde A. Light microscopic morphometric analysis of castration effects in the different lobes of the rat prostate. Prostate 13 (1988) 221-232
106. Kolesnick R., and Fuks Z. Ceramide: A signal for apoptosis or mitogenesis? (comment) (review). J. Exp. Med. 181 (1995) 1949-1952
107. Korsmeyer S.J., Shutter J.R., Veis D.J., Merry D.E., and Oltvai Z.N. Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death (review). Semin. Cancer Biol. 4 (1993) 327-332
108. Krajewski S., Bodrug S., Gascoyne R., Berean K., Krajewska M., and Reed J.C. Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes. Am. J. Pathol. 145 (1994) 515-525
109. Krajewski S., Bodrug S., Krajewska M., Shabaik A.a.^R., Berean K., and Reed J.C. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am. J. Pathol. 146 (1995) 1309-1319
110. Krajewski S., Krajewska M., Shabaik A., Miyashita T., Wang H.G., and Reed J.C. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am. J. Pathol. 145 (1994) 1323-1336
111. Krajewski S., Krajewska M., Shabaik A., Wang H.G., Irie S., Fong L., and Reed J.C. Immunohistochemical analysis of in vivo patterns of Bcl-x expression. Cancer Res. 54 (1994) 5501-5507
112. Kuida K., Lippke J.A., Ku G., Harding M.W., Livingston D.J., Su M.S., and Flavell R.A. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267 (1995) 2000-2003
113. Kumar S., Kinoshita M., Noda M., Copeland N.G., and Jenkins N.A. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev. 8 (1994) 1613-1626
114. Lahti J.M., Xiang J., Heath L.S., Campana D., and Kidd V.J. PITSLRE protein kinase activity is associated with apoptosis. Mol. Cell. Biol. 15 (1995) 1-11
115. Laster S.M., Wood J.G., and Gooding L.R. Tumor necrosis factor can induce both apoptotic and necrotic forms of cell death. J. Immunol. 141 (1988) 2629-2634
116. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., and Earnshaw W.C. Cleavage of poly(ADP-ribose)polymerase by a proteinase with properties like ICE. Nature (London) 371 (1994) 346-347
117. Li P., Allen H., Banerjee S., Franklin S., Herzog L., Johnston C., McDowell J., Paskind M., Rodman L., Salfeld J., et al. Mice deficient in IL-1 betaconverting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell (Cambridge, Mass.) 80 (1995) 401-411
118. Linette G.P., and Korsmeyer S.J. Differentiation and cell death: Lessons from the immune system. Curr. Opin. Curr. Biol 6 (1994) 809-815
119. Los M., Van de Craen M., Penning L.C., Schenk H., Westendorp M., Baeuerle P.A., Droge W., Krammer P.H., Fiers W., and Schulze-Osthoff K. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature (London) 375 (1995) 81-83
120. L and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone. Cell Growth Differ. 6 (1995) 647-653
121. Martin S.J., Lennon S.V., Bonham A.M., and Cotter T.G. Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis. J. Immunol. 145 (1990) 1859-1867
122. Martin S.J., O'Brien G.A., Nishioka W.K., McGahon A.J., Mahboubi A., Saido T.C., and Green D.R. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J. Biol. Chem. 270 (1995) 6425-6428
123. Mashima T., Naito M., Kataoka S., Kawai H., and Tsuruo T. Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells. Biochem. Biophys. Res. Commun. 209 (1995) 907-915
124. McConkey D.J., Hartzell P., Nicotera P., Wyllie A.H., and Orrhenius S. Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress. Toxicol Lett. 42 (1988) 123-130
125. Mekori Y.A., Oh C.K., and Metcalfe D.D. The role of c-kit and its ligand, stem cell factor, in mast cell apoptosis (review). Int. Arch. Allergy Immunol. 107 (1995) 136-138
126. Miura M., Zhu H., Rotello R., Hartwieg E.A., and Yuan J. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell (Cambridge, Mass.) 75 (1993) 653-660
127. Mixter P.F., Russell J.Q., and Budd R.C. Delayed kinetics of T lymphocyte anergy and deletion in lpr mice. J. Autoimmun. 7 (1994) 697-710
128. Motoyama N., Wang F., Roth K.A., Sawa H., Nakayama K., Negishi I., Senju S., Zhang Q., Fujii S., and Loh D.Y. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267 (1995) 1506-1510
129. rel III, members of the ICE/CED-3 family of cysteine proteases. J. Biol. Chem. 270 (1995) 15870-15876
130. Muzio M., Chinnaiyan A.M., Kischkel F.C., O'Rourke K., Shevchenko A., Ni J., Scaffidi C., Bretz J.D., Zhang M., Gentz R., Mann M., Krammer P.H., Peter M.E., and Dixit V.M. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85 (1996) 817-827
131. Nagata S., and Suda T. Fas and Fas ligand: lpr and gld mutations (review). Immunol. Today 16 (1995) 39-43
132. Nagata S. Mutations in the Fas antigen gene in lpr mice (review). Semin. Immunol. 6 (1994) 3-8
133. Nakajima H., Golstein P., and Henkart P.A. The target cell nucleus is not requried for cell-mediated granzyme- or Fas-based cytotoxicity. J. Exp. Med. 181 (1995) 1905-1909
134. Neamati N., Fernandez A., Wright S., Kiefer J., and McConkey D.J. Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei. J. Immunol. 154 (1995) 3788-3795
135. Nguyen M., Branton P.E., Walton P.A., Oltvai Z.N., Korsmeyer S.J., and Shore G.C. Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus. J. Biol. Chem. 269 (1994) 16521-16524
136. Ni R., Tomita Y., Matsuda K., Ichihara A., Ishimura K., Ogasawara J., and Nagata S. Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp. Cell Res. 215 (1994) 332-337
137. Nicholson D.W., Ali A., Thornberry N.A., Vaillancourt J.P., Ding C.K., Gallant M., Gareau Y., Griffin P.R., Labelle M., Lazebnik Y.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis (see comments). Nature (London) 376 (1995) 37-43
138. Nishimura Y., Ishii A., Kobayashi Y., Yamasaki Y., and Yonehara S. Expression and function of mouse Fas antigen on immature and mature T cells. J. Immunol. 154 (1995) 4395-4403
139. Obeid L.M., Linardic C.M., Karolak L.A., and Hannun Y.A. Programmed cell death induced by ceramide. Science 259 (1993) 1769-1771
140. Oehm A., Behrmann I., Falk W., Pawlita M., Maier G., Klas C., Li-Weber M., Richards S., Dhein J., Trauth B.C., Ponstingl H., and Krammer P.H. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily.Sequence identity with the Fas antigen. J. Biol. Chem. 267 (1992) 10709-10715
141. Ogasawara J., Suda T., and Nagata S. Selective apoptosis of CD4+CD8+thymocytes by the anti-Fas antibody. J. Exp. Med. 181 (1995) 485-491
142. Ogasawara J., Watanabe-Fukunaga R., Adachi M., matsuzawa A., Kasugai T., Kitamura Y., Itoh N., Suda T., and Nagata S. Lethal effect of the anti-Fas antibody in mice. Nature (London) 364 (1993) 806-809
143. Ohta H., Sweeney E.A., Masamune A., Yatomi Y., Hakomori S., and Igarashi Y. Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res. 55 (1995) 691-697
144. Ohta H., Yatomi Y., Sweeney E.A., Hakomori S., and Igarashi Y. A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils. FEBS Lett. 355 (1994) 267-270
145. Oltvai Z.N., Milliman C.L., and Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell (Cambridge, Mass.) 74 (1993) 609-619
146. Orchansky P.L., and Teh H.S. Activation-induced cell death in proliferating T cells is associated with altered tyrosine phosphorylation of TCR/CD3 subunits. J. Immunol. 153 (1994) 615-622
147. Oshimi Y., and Miyazaki S. Fas antigen-mediated DNA fragmentation and apoptotic morphologic changes are regulated by elevated cytosolic Ca2+ level. J. Immunol. 154 (1995) 599-609
148. Owen-Schaub L.B., Zhang W., Cusack J.C., Angelo L.S., Santee S.M., Fujiwara T., Roth J.A., Deisseroth A.B., Zhang W.W., Kruzel E., and Radinsky R. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol. Cell. Biol. 15 (1995) 3032-3040
149. Passarelli A.L., and Miller L.K. Identification and transcriptional regulation of the baculovirus lef-6 gene. J. Virol. 68 (1994) 4458-4467
150. Pircher H., Muller K.P., Kyewski B.A., and Hengartner H. Thymocytes can tolerize thymocytes by clonal deletion in vitro. Int. Immunol. 4 (1992) 1065-1069
151. Quintans J., Kilkus J., McShan C.L., Gottschalk A.R., and Dawson G. Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem. Biophys. Res. Commun. 202 (1994) 710-714
152. Quirk S.M., Cowan R.G., Joshi S.G., and Henrikson K.P. Fas antigenmediated apoptosis in human granulosa/luteal cells. Biol. Reprod. 52 (1995) 279-287
153. Rabizadeh S., LaCount D.J., Friesen P.D., and Bredesen D.E. Expression of the baculovirus p35 gene inhibits mammalian neural cell death. J. Neurochem. 61 (1993) 2318-2321
154. Ray C.A., Black R.a., Kronheim S.R., Greenstreet T.A., Sleath P.R., and Salvesen G.S. Pickup DJ. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β-converting enzyme. Cell (Cambridge, Mass.) 69 (1992) 597-604
155. Reynolds J.E., Yang T., Qian L., Jenkinson J.D., Zhou P., Eastman A., and Craig R.W. Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells. Cancer Res. 54 (1994) 6348-6352
156. Richardson B.C., Lalwani N.D., Johnson K.J., and Marks R.M. Fas ligation triggers apoptosis, in macrophages but not endothelial cells. Eur. J. Immunol. 24 (1994) 2640-2645
157. Robaye B., Doskeland A.P., Suarez-Huerta N., Doskeland S.O., and Dumont J.E. Apoptotic cell death analyzed at the molecular level by two-dimensional gel electrophoresis. Electrophoresis 15 (1994) 503-510
158. Rothstein T.L., Wang J.K., Panka D.J., Foote L.C., Wang Z., Stanger B., Cui H., Ju S.T., and Marshak-Rothstein A. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature (London) 374 (1995) 163-165
159. Sabourin J.C., Martin A., Baruch J., Truc J.B., Gompel A., and Poitout P. Bcl-2 expression in normal breast tissue during the menstrual cycle. Int. J. Cancer 59 (1994) 1-6
160. Sambrano G.R., and Steinberg D. Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: Role ofmembrane phosphatidylserine. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 1396-1400
161. Sarin A., Nakajima H., and Henkart P.A. A protease-dependent TCR-induced death pathway in mature lymphocytes. J. Immunol. 154 (1995) 5806-5812
162. Sato T., Hanada M., Bodrug S., et al. Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 9238-9242
163. Sato T., Irie S., Kitada S., and Reed J.C. FAP-1: A protein tyrosine phosphatase that associates with Fas. Science 268 (1995) 411-415
164. Schlegel J., Peters I., and Orrenius S. Isolation and partial characterization of a protease involved in Fas-induced apoptosis. FEBS Lett. 364 (1994) 139-142
165. Schulze-Osthoff K., Krammer P.H., and Droge W. Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological death. EMBO. J. 13 (1994) 4587-4596
166. Schulze-Osthoff K., Walczak H., Droge W., and Krammer P.H. Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell. Biol. 127 (1994) 15-20
167. Selvakumaran M., Lin H.K., Miyashita T., Wang H.G., Krajewski S., Reed J.C., Hoffman B., and Liebermann D. Immediate early up-regulation of bax expression by p53 but not TGF beta 1: A paradigm for distinct apoptotic pathways. Oncogene 9 (1994) 1791-1798
168. Sentman C.S., Shutter J.R., Hockenberg D., Kanagawa O., and Korsmeyer S.J. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell (Cambridge, Mass.) 67 (1991) 879-888
169. Shen Y., and Shenk T.E. Viruses and apoptosis (review). Curr. Opin. Genet. Dev. 5 (1995) 105-111
170. Shi L., Kam C.M., Powers J.C., Aebersold R., and Greenberg A.H. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J. Exp. Med. 176 (1992) 1521-1529
171. l . Nature (London) 374 (1995) 811-813
172. Singer G.G., Carrera A.C., Marshak-Rothstein A., Martinez C., and Abbas A.K. Apoptosis, Fas and systemic autoimmunity: The MRL-lpr/lpr model (review). Curr. Opin. Immunol. 6 (1994) 913-920
173. Sobel E.S., Kakkanaiah V.N., Rapoport R.G., Eisenberg R.a., and Cohen P.L. The abnormal lpr double-negative T cell fails to proliferate in vivo. Clin. Immunol. Immunopathol. 74 (1995) 177-184
174. Stanger B.Z., Leder P., Lee T.H., Kim E., and Seed B. A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell (Cambridge, Mass.) 81 (1995) 513523
175. Steinberg A.D. MRL-lpr/lpr disease: Theories meet Fas (review). Semin. Immunol. 6 (1994) 55-69
176. Steller H. Mechanisms and genes of cellular suicide. Science 267 (1995) 1445-1449
177. Su X., Zhou T., Wang Z., Yang P., Jope R.S., and Mountz J.D. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cell blocks Fas-mediated apoptosis. Immunity 2 (1995) 353-362
178. Suda T., and Nagata S. Purification and characterization of the Fas-ligand that induces apoptosis. J. Exp. Med. 179 (1994) 873-879
179. Suda T., Okazaki T., Naito Y., Yokota T., Arai N., Ozaki S., Nakao K., and Nagata S. Expression of the Fas ligand in cells of T cell lineage. J. Immunol. 154 (1995) 3806-3813
180. Sugimoto A., Friesen P.D., and Rothman J.H. Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans. EMBO J. 13 (1994) 2023-2028
181. Takahashi T., Tanaka M., Inazawa J., Abe T., Suda T., and Nagata S. Human Fas ligand: Gene structure, chromosomal location and species specificity. Int. Immunol. 6 (1994) 1567-1574
182. Takayama S., Sato T., Krajewski S., Kochel K., Irie S., Millan J.A., and Reed J.C. Cloning functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity. Cell (Cambridge, Mass.) 80 (1995) 279-284
183. Takizawa T., Fukuda R., Miyawaki T., Ohashi K., and Nakanishi T. Activation of the apoptotic Fas antigen-encoding gene upon influenza virus infection involving spontaneously produced beta-interferon. Virology 209 (1995) 288-296
184. Tamura A., and Yui K. Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice. J. Immunol. 155 (1995) 499-507
185. Tanaka M., Ito H., Adachi S., Akimoto H., Nishikawa T., Kasajima T., Marumo F., and Hiroe M. Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ. Res. 75 (1994) 426-433
186. Tanaka M., Suda T., Takahashi T., and Nagata S. Expression of the functional soluble form of human fas ligand in activated lymphocytes. EMBO J. 14 (1995) 1129-1135
187. Tartaglia L.A., Ayres T.M., Wong G.H., and Goeddel D.V. A novel domain within the 55 kD TNF receptor signals cell death. Cell (Cambridge, Mass.) 74 (1993) 845-853
188. Tewari M., Beidler D.R., and Dixit V.M. CrmA-inhibitable cleavage of the 70kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis, factor inducedapoptosis. J. Biol. Chem. 270 (1995) 18738-18741
189. Tewari M., and Dixit V.M. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem. 270 (1995) 3255-3260
190. Tewari M., Quan L.T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D.R., Poirier G.G., Salvesen G.S., and Dixit V.M. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose)polymerase. Cell (Cambridge, Mass.) 81 (1995) 801-809
191. Thornberry N.A., and Bull H.G. The novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature (London) 356 (1992) 768
192. Tolstoy L.N. Anna Karenina (1912), Alfred Knopf, New York
193. Veis D.J., Sorenson C.M., Shutter J.R., and Korsmeyer S.J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell (Cambridge, Mass.) 75 (1993) 229-240
194. Vignaux F., Vivier E., Malissen B., Depraetere V., Nagata S., and Golstein P. TCR/CD3 coupling to Fas-based cytotoxicity. J. Exp. Med. 181 (1995) 781-786
195. Voelkel-Johnson C., Entingh A.J., Wold W.S., Gooding L.R., and Laster S.M. Activation of intracellular proteases is an early event in TNF-induced apoptosis. J. Immunol. 154 (1995) 1707-1716
196. Walker N.P., Talanian R.V., Brady K.D., Dang L.C., Bump N.J., Ferenz C.R., Franklin S., Ghayur T., Hackett M.C., Hammill L.D., et al. Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: A (p20/p10)2 homodimer. Cell (Cambridge, Mass.) 78 (1994) 343-352
197. Wang L., Miura M., Bergeron L., Zhu H., and Yuan J. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell (Cambridge, Mass.) 78 (1994) 739-750
198. Weller M., Frei K., Groscurth P., Krammer P.H., Yonekawa Y., and Fontana A. Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines. J. Clin. Invest. 94 (1994) 954-964
199. Westendorp M.O., Frank R., Ochsendauer C., Stricker K., Dhein J., Walczak H., Debatin K.M., and Krammer P.H. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp 120. Nature (London) 375 (1995) 497-500
200. Williams G.T., Smith C.A., Spooncer E., Dexter T.M., and Taylor D.R. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature (London) 343 (1990) 76-79
201. Williams M.S., and Henkart P.A. Apoptotic cell death induced by intracellular proteolysis. J. Immunol. 153 (1994) 4247-4255
202. Wong G.H., and Goeddel D.V. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J. Immunol. 152 (1994) 1751-1753
203. Wong M., and Smulson M. A relationship between nuclear poly(ADP ribosylation) and acetylation posttranslational modifications. 2. Histone studies. Biochemistry 23 (1984) 3272-3730
204. Wright S.C., Wei Q.S., Zhong J., Zheng H., Kinder D.H., and Larrick J.W. Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation. J. Exp. Med. 180 (1994) 2113-2123
205. Wright D.A., Futcher B., Ghosh P., and Geha R.S. Association of human Fas (CD95) with a ubiquitin conjugating enzyme (UBC-FAP). J. Biol. Chem. 27 (1996) 31037-31043
206. Wyllie A.H., Kerr J.F., and Currie A.R. Cell death: The significance of apoptosis (review). Int. Rev. Cytol. 68 (1980) 251-306
207. Wyllie A.H., Morris R.G., Smith A.L., and Dunop D. Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol. 142 (1984) 66-77
208. Xue D., and Horvitz H.R. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature (London) 377 (1995) 248-251
209. L and Bcl-2, displaces Bax and promotes cell death. Cell (Cambridge, Mass.) 80 (1995) 285-291
210. Yang T., Kozopas K.M., and Craig R.W. The intracellular distribution and pattern of expression of MCl-1 overlap with, but are not identical to, those of Bcl-2. J. Cell Biol. 128 (1995) 1173-1184
211. Yang Y., Mercep M., Ware C.F., and Ashwell J.D. Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: Inhibition of Fas ligand expression by retinoic acid and glucocorticoids. J. Exp. Med. 181 (1995) 1673-1682
212. Yao B., Zhang Y., Delikat S., Mathias S., Basu S., and Kolesnick R. Phosphorylation of Raf by ceramide-activated protein kinase. Nature (London) 378 (1995) 307-310
213. Yin, X-M., Oltvai, Z. N., and Korsmeyer, S. J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature (London) 369, 321-323.
214. Yonehara S., Nishimura Y., Kishil S., Yonehara M., Takazawa K., Tamatani T., and Ishii A. Involvement of apoptosis antigen Fas in clonal deletion of human thymocytes. Int. Immunol. 6 (1994) 1849-1856
215. Yuan J., Shaham S., Ledoux S., Ellis H.M., and Horvitz H.R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell (Cambridge, Mass.) 75 (1993) 641-652
216. s interaction. Biochem. Biophys. Res. Commun. 208 (1995) 950-956