Portrait of an executioner: The molecular mechanism of Fas/APO-1-induced apoptosis

Seminars in Immunology

Volumn 9, Issue 1, 1997, Pages 69-76

  Chinnaiyan, Arul M ^a   Dixit, Vishva M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; CD95 (Fas APO 1) FLICE; Signal transduction

Indexed keywords

CELL SURFACE RECEPTOR; FAS ANTIGEN; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; CELL DEATH; DOWN REGULATION; IMMUNOREGULATION; LIGAND BINDING; MOUSE; NONHUMAN; T LYMPHOCYTE;

EID: 0031079805     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1996.0055     Document Type: Article

References (84)

1. 1. Stellar H (1995) Mechanisms and genes of cellular suicide. Science 267:1445-1449
2. 2. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462
3. 3. Nagata S, Golstein P (1995) The Fas death factor. Science 267:1449-1456
4. 4. Tartaglia LA, Goeddel DV (1992) Two TNF receptors. Immunol Today 13:151-153
5. 5. Smith CA, Davis T, Anderson D, Solam L, Beckmann MP, Jerzy R, et al (1990) A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248:1019-1023
6. 6. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S-I, Sameshima M, et al (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233-243
7. 7. Trauth BC, Klas C, Peters AMJ, Matzku S. Moller P, Falk W, et al (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301-305
8. 8. Tartaglia LA, Ayres TM, Wong GHW, Goeddel DV (1993) A novel domain within the 55 kd TNF receptor signals cell death. Cell 74:845-853
9. 9. Itoh N, Nagata S (1993) A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 268:10932-10937
10. 10. Golstein P, Marguet D, Depraetere V (1995) Homology between reaper and the cell death domains of Fas and TNFR1 [letter]. Cell 81:185-186
11. 11. White K, Grether ME, Abrams JM, Young L, Farrell K, Steller H (1994) Genetic control of programmed cell death in Drosophila. Science 264:677-683
12. 12. White K, Tahaoglu E, Stellar H (1996) Cell killing by the Drosophila gene reaper. Science 271:805-807
13. 13. Watanabe-Fukunaga R, Brannan CI, Itoh N, Yonehara S, Copeland NG, Jenkins NA, et al (1992) The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol 148:1274-1279
14. 14. Krammer PH, Behrmann I, Daniel P, Dhein J, Debatin KM (1994) Regulation of apoptosis in the immune system. Curr Opin Immunol 6:279-289
15. 15. Leithauser F, Dhein J, Mechtersheimer G, Koretz K, Bruderlein S, Henne C, et al (1993) Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab Invest 69:415-429
16. 16. Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS, et al (1992) Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med 176:1645-1656
17. 17. Krammer PH, Dhein J, Walczak H, Behrmann I, Mariani S, Matiba B, et al (1994) The role of APO-1-mediated apoptosis in the immune system. Immunol Rev 142:175-191
18. 18. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314-317
19. 19. Mariani SM, Matiba B, Armandola EA, Krammer PH (1994) The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice. Eur J Immunol 24:3119-3123
20. 20. Cohen PL, Eisenberg RA (1992) The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane [published erratum appears in Immunol Today 1993 14:97] Immunol Today 13:427-428
21. 21. Singer GG, Abbas AK (1994) The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365-371
22. 22. Russell JH, Rush B, Weaver C, Wang R (1993) Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci USA 90:4409-4413
23. 23. Fisher GH, Rosenberg FJ, Straus SE, Dale JK, Middleton LA, Lin AY, et al (1995) Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81:935-946
24. 24. Rieux-Laucat E, Le Deist F, Hivroz C, Roberts IA, Debatin KM, Fischer A, et al (1995) Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268:1347-1349
25. 25. Sneller MC, Straus SE, Jaffe ES, Jaffe JS, Fleisher TA, Stetler-Stevenson M et al (1992) A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease. J Clin Invest 90:334-341
26. 26. Westendorf MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, et al (1995) Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp 120. Nature 375:497-500
27. 27. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA (1995) Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 181:2029-2036
28. 28. Stricker K, Knipping E, Benner A. Krammer PH, Debatin KM (1995) Anti-APO-1 (CD95) autoantibodies and T cell deletion in HIV-1 infected children. Submitted
29. 29. Brunner T, Mogil RJ. LaFace D, Yoo NJ, Mahboubi A, Echeverri F, et al. (1995) Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373:441-444
30. 30. Ju ST, Panka DJ, Cui H, Ettinger R, el-Khatib M, Sherr DH, et al (1995) Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444-448
31. 31. Dhein J, Walczak H, Baumler C, Debatin KM, Krammer PH (1995) Autocrine T-cell suicide mediated by APO-1 (Fas/ CD95) [see comments]. Nature 373:438-441
32. 32. Galle PR, Hofmann WJ, Walczak H, Schaller H, Otto G. Stremmel W. et al (1996) Involvement of CD95 (APO-1/Fas) receptor and ligand in liver damage. JEM 182:1223-1230
33. 33. Friesen C, Herr I, Krammer PH, Debatin K-M (1996) Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nature Med 2:574-577
34. 34. Berke G (1995) The CTL's kiss of death. Cell 81:9-12
35. 35. Berke G (1995) Unlocking the secrets of CTL and NK cells. Immunol Today 16:343-346
36. 36. Smyth MJ, Trapani JA (1995) Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol Today 16:202-206
37. 37. Kagi D, Vignaux F, Ledermann B, Burki K, Depraetere V, Nagata S, et al (1994) Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity. Science 265:528-530
38. 38. Lowin B, Hahne M, Mattmann C, Tschopp J (1994) Cytolytic T-cell cytotoxicity is mediated through perforin and Fas. Nature 370:650-652
39. 39. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA (1995) Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270:1189-1192
40. 40. Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC (1995) A role for CD95 ligand in preventing graft rejection. Nature 377:630-632
41. 41. Ellis HM, Horvitz HR (1986) Genetic control of programmed cell death in the nematode Caenorhabditis elegans. Cell 44:817-829
42. 42. Yuan JY, Horvitz HR (1990) The Caenorhabditis elegans genes ced-3 and ced4 act cell autonomously to cause programmed cell death. Dev Biol 138:33-41
43. 43. Yaan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993) The C. elegans Cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75:641-652
44. 44. Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J (1993) Induction of Apoptosis in fibroblasts by IL-1β converging enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75:653-660
45. 45. Williams MS, Henkart PA (1994) Apoptotic cell death induced by intracellular proteolysis. J Immunol 4247-4255
46. 46. Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA (1994) Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev 8:1613-1626
47. 47. Wang L, Miura M, Bergeron L, Zhu H, Yuan J (1994) Ich-1, an ICE-ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78:739-750
48. 48. Fernandes-Alnemri T, Litwack G, Alnemri ES (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme. J Biol Chem 269:30761-30764
49. 49. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, et al (1995) Identification and inhibition of the ICE/ CED-3 protease necessary for mammalian apoptosis. Nature 376:37-43
50. 50. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, et al (1995) Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81:801-809
51. 51. Munday NA, Vaillancourt JP, Ali A, Casano FJ, Miller DK, Molineaux SM, et al (1995) Molecular cloning and proapoptotic activity of ICEreIII and ICEreIIII, members of the ICE/CED-3 family of cysteine proteases. J Biol Chem 270:15870-15876
52. 52. Faucheu C, Diu A, Chan AW, Blanchet AM, Miossec C, Herve F, et al (1995) A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells. EMBO J 14:1914-1922
53. 53. Kamens J, Paskind M, Hugunin M, Talanian RV, Allen H, Banach D, et al (1995) Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases. J Biol Chem 270:15250-15256
54. 54. Fernandes-Alnemri T, Litwack G, Alnemri ES (1995) Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res 55:2737-2742
55. 55. Duan H, Chinnaiyan AM, Hudson PL, Wing JP, He W, Dixit VM (1996) ICE-LAP3, a novel mammalian homolog of the Caenorhabditis elegans cell death protein CED-3 is activated during Fas-and tumor necrosis factor-induced apoptosis. J Biol Chem 271:35013-35035
56. 56. Lippke JA, Gu Y, Samecki C, Caron PR, Su MS-S (1996) Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. J Biol Chem 271:1825-1828
57. 57. Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, et al (1995) Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res 55:6045-6052
58. 58. Duan H, Orth K, Chinnaiyan A, Poirier G, Froelich CJ, He W-W, et al (1996) ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. JBC, in press
59. 59. Muzio M, Chinnaiyan AM, Kischkel KC, O'Rourke K, Shevchenko A, Ni J, et al (1996) FLICE, A novel FADD homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/ APO-1) death-inducing signaling complex. Cell 85:817-827
60. 60. Boldin MP, Goncharov TM, Goltsev YV, Wallach D (1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/ APO-1-and TNF receptor-induced cell death. Cell 85:803-815
61. 61. Fernandes-Alnemri T, Armstrong RC, Krebs J. Srinivasula SM, Wang L, Bullrich F et al (1996) In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cyteine protease containing two FADD-like domains. PNAS 93:7464-7469
62. 62. Wang S, Miura M, Jung Y-K, Zhu H, Gagliardini V, Lianfa S, et al (1996) Identification and characterization of Ich-3, a member of the interleukin-1b converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. JBC 271:20580-20587
63. 63. Orth K, Chinnaiyan AM, Garg M, Froelich CJ, Dixit VM (1996) The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. JBC 271:16443-16446
64. 64. Chinnaiyan AM, Orth K, O'Rourke K, Duan H, Poirier GG, Dixit VM (1996) Molecular ordering of the cell death pathway: bcl-2 and bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem 271:4573-4576
65. 65. Schlegel J, Peters I, Orrenius S, Miller DK, Thornberry NA, Yamin T-T, et al (1996) CPP32/ Apopain is the key interleukin-1β converting enzyme-like protease involved in Fas-mediated apoptosis. J Biol Chem 271:1841-1844
66. 66. Tewari M, Dixit (1995) Fas-and tumor necrosis factor-induced apoptotis is inhibited by the poxvirus crmA gene product. J Biol Chem 270:3255-3260
67. 67. Los M, Van de Craen M, Penning LC, Schenk H, Westendorp M, Baeuerle PA, et al (1995) Requirement of an ICE/CED-3 protease for Fas/ APO-1-mediated apoptosis. Nature 375:81-83
68. 68. Enari M, Hug H, Nagata S (1995) Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375:78-81
69. 69. Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS, et al (1997) Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme. Cell 69:597-604
70. 70. Beidler DR, Tewari MT, Friesen PD, Poirier G, Dixit VM (1995) The Baculovirus p35 protein inhibits Fas-and tumor necrosis factor-induced apoptosis. J Biol Chem 270:16526-16528
71. 71. Xue D, Horvitz HR (1995) Inhibition of the Caenorhabditis elegans cell death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377:248-251
72. 72. Pronk GJ, Ramer K, Amiri P, Williams LT (1996) Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER. Science 271:808-810
73. 73. Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM (1995) FADD, a novel death domain-containing protein. interacts with the death domain of Fas and initiates apoptosis. Cell 81:505-512
74. 74. Cleveland JL, Ihle JN (1995) Contenders in FasL/TNF signaling. Cell 81:479-482
75. 75. Hsu H, Xiong J, Goeddel DV (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81:495-504
76. 76. Stanger BZ, Leder P, Lee TH, Kim E, Seed B (1995) RIP: a novel protein containing a death domain that interacts with Fas/ APO-1 (CD95) in yeast and causes cell death. Cell 81:513-523
77. 77. Boldin MP, Varfolomeev EE, Pancer Z, Mett IL, Camonis JH, Wallach D (1995) A novel protein that interacts with the death domain of Fas/ APO1 contains a sequence motif related to the death domain. J Biol Chem 270:7795-7798
78. 78. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, et al (1995) Cytoxicity-dependent APO-1(FaS/ CD95)-associated proteins (CAP) form a death-inducing signalling complex (DISC) with the receptor. EMBO 14:5579-5588
79. 79. Hsu H, Shu H-B, Pan M-P, Goeddel DV (1996) TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways. Cell 84:299-308
80. 80. Hsu H, Huang J, Shu H-B, Baichwal V, Goeddel DV (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4:387-396
81. 81. Chinnaiyan AM, Tepper CG, Seidin MF, O'Rourke K, Kischkel FC, Hellbardt S, et al (1996) FADD/MORT1 is a common mediator of CD95 (Fas/ APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 271:4961-4965
82. 82. Wilm M, Shevchenko A, Houthaeve T, Breit S, Schweigerer L, Fotsis T, et al (1996) Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature 379:466-469
83. 83. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS-S, et al (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267:2000-2003
84. 84. Enari M, Talanian R, Wong W, Nagata S (1996) Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380:723-726