Cell cycle-regulated transcription by the human immunodeficiency virus type 1 Tat transactivator

Journal of Virology

Volumn 74, Issue 2, 2000, Pages 652-660

  Kashanchi, Fatah ^a   Agbottah, Emmanuel T ^a   Pise Masison, Cynthia A ^a   Mahieux, Renaud ^a   Duvall, Janet ^a   Kumar, Ajit ^b   Brady, John N ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

ARTICLE; BINDING SITE; CELL CYCLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL;

CELL CYCLE; CELL EXTRACTS; EPITOPES; G1 PHASE; G2 PHASE; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAT; GENE PRODUCTS, VPR; HELA CELLS; HEMAGGLUTININS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 0033987568     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.2.652-660.2000     Document Type: Article

References (92)

1. Allday, M. J., G. J. Inman, D. H. Crawford, and P. J. Farrell. 1995. DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective. EMBO J. 14:4994-5005.
2. Apone, L. M., C. M. Virbasius, J. C. Reese, and M. R. Green. 1996. Yeast TAF(II)90 is required for cell-cycle progression through G2/M hut not for general transcription activation. Genes Dev. 10:2368-2380.
3. Balotta, C., P. Lusso, R. Crowley, R. C. Gallo, and G. Franchini. 1993. Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages. J. Virol. 67:4409-4414.
4. 2 accumulation by a mechanism which differs from DNA damage checkpoint control. J. Virol. 70:2324-2331.
5. Berkhout, B., and K. T. Jeang. 1991. Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains. Nucleic Acids. Res. 19:6169-6176.
6. Berkhout, B., R. H. Silverman, and K. T. Jeang. 1989. Tat trans-activates the human immunodeficiency virus through a nascent RNA target. Cell 59:273-282.
7. Biswas, D. K., M. A. Tius, J. Zhuo, and A. B. Pardee. 1996. Canventol inhibits HIV-1 replication by Tat-induced Tar-independent mechanism. J. Acquir. Immune Delic. Syndr. Hum. Retrovirol. 12:120-127.
8. Bohan, C. A., F, Kashanchi, B. Ensoli, L. Buonaguro, K. A. Boris-Lawrie, and J. N. Brady. 1992. Analysis of Tat transactivatiori of human immuno-deficiency virus transcription in vitro. Gene Exp. 2:391-407.
9. Brother, M. B., H. K. Chang, J. Lisziewicz, D. Su, L. C. Murty, and B. Ensoli. 1996. Block of Tat-mediated transactivation of tumor necrosis factor beta gene expression by polymeric-TAR decoys. Virology 222:252-256.
10. Buonaguro, L., G. Barillari, H. K. Chang, C. A. Bohan, V. Kao, R. Morgan, R. C. Gallo, and B. Ensoli. 1992. Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines. J. Virol. 66:7159-7167.
11. Chen, P. L., D. J. Riley, Y. Chen, and W. H. Lee. 1996. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10:2794-2804.
12. Chesebro, B., J. Nishio, S. Perryman, A. Cann, W. O'Brien, I. S. Y. Chen, and K. Wehrly. 1991. Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophages. J. Virol. 65:5782-5789.
13. Chiang, C.-M., and R. G. Roeder. 1995. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. Science 267: 531-534.
14. Churcher, M. J., C. Lamont, F. Hamy, C. Dingwall, S. M. Green, A. D. Lowe, J. G. Butler, M. J. Gait, and J. Karn. 1993. High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region. J. Mol. Biol. 230:90-110.
15. Churcher, M. J., A. D. Lowe, M. J. Gait, and J. Karn. 1995. The RNA element encoded by the trans-activation-responsive region of human immunodeficiency virus type 1 is functional when displaced downstream of the start of transcription. Proc:. Natl. Acad. Sci. USA 92:2408-2412.
16. Cullen, B. R. 1991. Regulation of HIV-1 gene expression. FASEB J. 5:2361-2368.
17. Dyson, N. 1994. pRB, p107 and the regulation of the E2F transcription factor. J. Cell Sci. 18:81-87.
18. Feinberg, M. B., D. Baltimore, and A. D. Frankel. 1991. The role of Tat in the Human Immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation. Proc. Natl. Acad. Sci. USA 88:4045-4049.
19. Feng, S., and E. C. Holland. 1988. HIV-1 tat trans-activation requires the loop sequence within tar. Nature 334:165-167.
20. Fujinaga, K., T. P. Cujec, J. Peng, J. Garriga, D. H. Price, X. Grana, and B. M. Peterlin. 1998. The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. J. Virol. 72:7154-7159.
21. Garber, M. E., P. Wei, V. N. KewalRamani, T. P. Mayall, C. H. Herrmann, A. P. Rice, D. R. Liltman, and K. A. Jones. 1998. The interaction between HIV-1 Tat and human cyclin t requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. Genes Dev. 12:3512-3527.
22. Garcia, J. A., D. Harrich, E. Soultanakis, F. Wu, R. Mitsuyasu, and R. B. Gaynor. 1989. Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulation. EMBO J. 8:765-778.
23. Gebara, M. M., M. H. Sayre, and J. L. Corden. 1997. Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription. J. Cell Biochem. 64:390-402.
24. Goh, W. C., M. E. Rogel, C. M. Kinsey, S. F. Michael, P. N. Fultz, M. A. Nowak, B. H. Hahn, and M. Emerman. 1998. HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nat. Med. 4:65-71.
25. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyl transferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
26. Gottesfeld, J. M., V. J. Wolf, T. Dang, D. J. Forbes, and P. Hartl. 1994. Mitotic repression of RNA polymerase II transcription in vitro mediated by phosphorylation of a TFIIB component. Science 263:81-84.
27. Harrich, D., G. Mavankal, A. Mette-Snider, and R. B. Gaynor. 1995. Human immunodeficiency virus type 1 TAR element revertant viruses define RNA structures required for efficient viral gene expression and replication. J. Virol. 69:4906-4913.
28. Hattori, N., F. Michaels, K. Fargnoli, L. Marcon, R. C. Gallo, and G. Franchini. 1990. The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages. Proc. Natl. Acad. Sci. USA 87:8080-8084.
29. Hauber, J., and B. R. Cullen. 1988. Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat. J. Virol. 62:673-679.
30. Herrmann, C., and A. P. Rice. 1995. Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carhoxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. J. Virol. 69:1612-1620.
31. Herrmann, C. H., R. G. Carroll, P. Wei, K. A. Jones, and A. P. Rice. 1998. Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell lines. J. Virol. 72:9881-9888.
32. Herrmann, C. H., M. O. Gold, and A. P. Rice. 1996. Viral transactivators specifically target distinct cellular protein kinases that phosphorylate the RNA polymerase II C-terminal domain. Nucleic Acids Res. 24:501-508.
33. Hisatake, K., S. Hasegawa, R. Takada, Y. Nakatani, M. Horikoshi, and R. G. Roeder. 1993. The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1. Nature 362:179-181.
34. Jaumot, M., N. Agell, and O. Bachs. 1996. Putative nuclear cdk2 substrates in normal and transformed cells. Biochem. Biophys. Res. Commun. 219:560-564.
35. Jeang, K. T., Y. Chang, B. Berkhout, M. L. Hammarskjold, and D. Rekosh. 1991. Regulation of HIV expression: mechanisms of action of Tat and Rev. AIDS 5(Suppl. 2):S3-S14.
36. Jones, K. A. 1989. HIV trans-activation and transcription control mechanisms. New Biol. 1:127-135.
37. 2 + M phase of the cell cycle. J. Virol. 69:6304-6313.
38. Kashanchi, F., J. F. Duvall, and J. N. Brady. 1992. Electroporation of viral transactivator proteins into lymphocyte suspension cells. Nucleic Acids Res. 20:4673-4674.
39. Kashanchi, F., S. N. Khleif, J. F. Duvall, M. R. Sadaie, M. F. Radonovich, M. Cho, M. A. Martin, S.-Y. Chen, R. Weinmann, and J. N. Brady. 1996. Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex. J. Virol. 70:5503-5510.
40. Kashanchi, F., G. Piras, M. F. Radonovich, J. F. Duvall, A. Fattaey, C.-M. Chiang, R. G. Roeder, and J. N. Brady. 1994. Interaction of human TFIID with the HIV-1 transactivator Tat. Nature 367:295-299.
41. Kashanchi, F., R. I. Shibata, E. K. Ross, J. N. Brady, and M. A. Martin. 1994. Second-site long terminal repeat (LTR) revertants of replication-defective human immunodeficiency virus: effects of revertant TATA box motifs on virus infectivity, LTR-directed expression, in vitro RNA synthesis, and binding of basal transcription factors TFIID and TFIIA. J. Virol. 68: 3298-3307.
42. Kato, H., H. Sumimoto, P. Pognonec, C. Chen, C. A. Rosen, and R. G. Roeder. 1992. HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. Genes Dev. 6:655-666.
43. Laspia, M. F., A. P. Rice, and M. B. Mathews. 1989. HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation. Cell 59:283-292.
44. Laspia, M. F., P. Wendel, and M. B. Mathews. 1993. HIV-1 Tat overcomes inefficient transcriptional elongation in vitro. J. Mol. Biol. 232:732-746.
45. Leake, R. 1996. The cell cycle and regulation of cancer cell growth. Ann. N. Y. Acad. Sci. 784:252-262.
46. Lu, H., L. Zawel, L. Fisher, J. M. Egly, and D. Reinberg. 1992. Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II. Nature 358:641-645.
47. Luo, Y., and B. M. Peterlin. 1993. Juxtaposition between activation and basic domains of human immunodeficiency virus type 1 Tat is required for optimal interactions between Tat and TAR. J. Virol. 67:3441-3445.
48. Mancebo, H. S., G. Lee, J. Flygare, J. Tomassini, P. Luu, Y. Zhu, J. Peng, C. Blau, D. Hazuda, D. Price, and O. Flores. 1997. P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev. 11:2633-2644.
49. Manley, J. L., A. Fire, A. Cano, P. A. Sharp, and M. L. Gefter. 1980. DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract. Proc. Natl. Acad. Sci. USA 77:3855-3859.
50. Marciniak, R. A., B. J. Calnan, A. D. Frankel, and P. A. Sharp. 1990. HIV-1 Tat protein trans-activates transcription in vitro. Cell 63:791-802.
51. Marciniak, R. A., and P. A. Sharp. 1991. HIV-1 Tat protein promotes formation of more-processive elongation complexes. EMBO J. 10:4189-4196.
52. McCloskey, T. W., M. Ott, E. Tribble, S. A. Khan, S. Teichberg, M. O. Paul, S. Pahwa, E. Verdin, and N. Chirmule. 1997. Dual role of HIV Tat in regulation of apoptosis in T cells. J. Immunol. 158:1014-1019.
53. Naeve, G. S., A. Sharma, and A. S. Lee. 1991. Temporal events regulating the early phases of the mammalian cell cycle. Curr. Opin. Cell Biol. 3:261-268.
54. Nekhai, S., R. R. Shukla, and A. Kumar. 1997. A human primary T-lymphocyte-dcrived HlV-1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity. J. Virol. 71:7436-7441.
55. Nevins, J. R. 1992. Transcriptional regulation. A closer look at E2F. Nature 358:375-376.
56. Nigg, E. A. 1996. Cydin-dependent kinase 7: at the cross-roads of transcription. DNA repair and cell cycle control? Curr. Opin. Cell. Biol. 8:312-317.
57. Parada, C. A., and R. G. Roeder. 1996. Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. Nature 384:375-384.
58. Pfeifer, K., M. Bachmann, H. C. Schroder, B. A. Weiler, D. Ugarkovic, T. Okamoto, and W. E. G. Muller. 1991. Formation of a small ribonucleoprotein particle between Tat protein and trans-acting response element in human immunodeficiency virus-infected cells. J. Biol. Chem. 268:14620-14626.
59. Planelles, V., F. Bachelerie, J. B. M. Jowett, A. Haislip, Y. Xie, B. Peyman, T. Masuda, and I. S. Y. Chen. 1995. Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vpr. J. Virol. 69:5883-5889.
60. Planelles, V., J. B. M. Jowett, Q.-X. Li, Y. Xie, B. Hahn, and I. S. Y. Chen. 1996. Vpr-induced cell cycle arrest is conserved among primate lentiviruses. J. Virol. 70:2516-2524.
61. Pocsik, E., R. I. Mihalik, M. Penzes, H. Loetscher, H. Gallati, and B. B. Aggarwal. 1995. Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors. J. Cell. Biochem. 59:303-316.
62. Puri, R. K., and B. B. Aggarwal. 1992. Human immunodeficiency virus type 1 tat gene up-regulates interleukin 4 receptors on a human B-lymphoblastoid cell line. Cancer Res. 52:3787-3790.
63. Purvis, S. F., J. W. Jacobberger, R. M. Sramkoski, A. H. Patki, and M. M. Lederman. 1995. HIV type 1 Tat protein induces apoptosis and death in Jurkat cells. AIDS Res. Hum. Retrovir. 11:443-450.
64. Rautonen, J., N. Rautonen, N. L. Martin, and D. W. Wara. 1994. HIV type 1 Tat protein induces immunoglobulin and interleukin 6 synthesis by uninfected peripheral blood mononuclear cells. AIDS Res. Hum. Retrovir. 10: 781-785.
65. Reed, S. I., E. Bailly, V. Dulic, L. Hengst, D. Resnitzky, and J. Slingerland. 1994. G1 control in mammalian cells. J. Cell Sci. Suppl. 188:69-73.
66. Rounseville, M. P., and A. Kumar. 1992. Binding of a host cell nuclear protein to the stem region of human immunodeficiency virus type 1 trans-activation-responsive RNA. J. Virol. 66:1688-1694.
67. Sastry, K. J., M. C. Marin, P. N. Nehete, K. McConnell, A. K. el-Naggar, and T. J. McDonnell. 1996. Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells. Oncogene 13:487-493.
68. Segil, N., M. Guermah, A. Hoffmann, R. G. Roeder, and N. Heintz. 1996. Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization. Genes Dev. 10:2389-2400.
69. Sekiguchi, T., E. Noguchi, T. Hayashida, T. Nakashima, H. Toyoshima, T. Nishimoto, and T. Hunter. 1996. D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/ TAFII250 mutant cells arrest in G1 at the restrictive temperature. Genes Cells 1:687-705.
70. Serizawa, H., T. P. Makela, J. W. Conaway, R. C. Conaway, R. A. Weinberg, and R. A. Young. 1995. Association of Cdk-activating kinase subunits with transcription factor TFIIH. Nature 37-1:280-282.
71. Seroz, T., J. R. Hwang, V. Moncollin, and J. M. Egly. 1995. TFIIH: a link between transcription, DNA repair and cell cycle regulation. Curr. Opin. Genet. Dev. 5:217-221.
72. Shiekhattar, R., F. Mermelstein, R. P. Fisher, R. Drapkin, B. Dynlacht, H. C. Wessling, D. O. Morgan, and D. Reinberg. 1995. Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374: 283-287.
73. 1 cell state. Mol. Cell. Biol. 16:6965-6976.
74. Southgate, C., M. L. Zapp, and M. R. Green. 1990. Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein. Nature 345:640-642.
75. Southgate, C. D., and M. A. Green. 1991. The HIV-1 Tat protein activates transcription from an upstream DNA-binding site: implications for Tat function. Genes Dev. 5:2496-2507.
76. 1 at the nonpermissive temperature. Mol. Cell. Biol. 17:3284-3294.
77. Vacca, A., M. Farina, M. Maroder, E. Alesse, I. Screpanti, L. Frati, and A. Gulino. 1994. Human immunodeficiency virus type-1 Tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif. Biochem. Biophys. Res. Commun. 205:467-474.
78. Veschambre, P., P. Simard, and P. Jalinot. 1995. Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo. J. Mol. Biol. 250:169-180.
79. Wang, E. H., and R. Tjian. 1994. Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFI1250. Science 263:811-814.
80. Westendorp, M. O., M. Li-Weber, R. W. Frank, and P. H. Krammer. 1994. Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells. J. Virol. 68:4177-4185.
81. White, R. J., T. M. Gottlieb, C. S. Downes, and S. P. Jackson. 1995. Mitotic regulation of a TATA-binding-protein-containing complex. Mol. Cell. Biol. 15:1983-1992.
82. White, R. J., T. M. Gottlieb, C. S. Downes, and S. P. Jackson. 1995. Cell cycle regulation of RNA polymerase III transcription. Mol. Cell. Biol. 15:6653-6662.
83. Wu-Baer, F., W. S. Lane, and R. B. Gaynor. 1995. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. EMBO J. 14:5995-6009.
84. Wu-Baer, F., D. Sigman, and R. B. Gaynor. 1995. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. Proc. Natl. Acad. Sci. USA 92:7153-7157.
85. Yee, A. S., P. Raychaudhuri, L. Jakoi, and J. R. Nevins. 1989. The adeno-virus-inducible factor E2F stimulates transcription after specific DNA binding. Mol. Cell. Biol. 9:578-585.
86. Yonaha, M., T. Chibazakura, S. Kitajima, and Y. Yasukochi. 1995. Cell cycle-dependent regulation of RNA polymerase II basal transcription activity. Nucleic Acids Res. 23:4050-4054.
87. Yu, L., P. M. Loewenstein, Z. Zhang, and M. Green. 1995. In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP. J. Virol. 69:3017-3023.
88. Zhou, Q., T. G. Boyer, and A. J. Berk. 1993. Factors (TAFs) required for activated transcription interact with TATA box-binding protein conserved core domain. Genes Dev. 7:180-187.
89. Zhou, Q., D. Chen, E. Pierstorff, and K. Luo. 1998. Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages. EMBO J. 17:3681-3691.
90. Zhou, Q., and P. A. Sharp. 1995. Novel mechanism and factor for regulation by HIV-1 Tat. EMBO J. 14:321-328.
91. Zhou, Q., and P. A. Sharp. 1996. Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 tat. Science 274:605-610.
92. Zhu, Y., T. Pe'ery, J. Peng, Y. Ramanathan, N. Marshall, T. Marshall, B. Amendt, M. B. Mathews, and D. H. Price. 1997. Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. Genes Dev. 11:2622-2632.