Methyl-substituted dispiro-1,2,4,5-tetraoxanes: Correlations of structural studies with antimalarial activity

Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2000, Pages 1246-1249

  McCullough, Kevin J ^a   Wood, James K ^b   Bhattacharjee, Apurba K ^d   Dong, Yuxiang ^c   Kyle, Dennis E ^d   Milhous, Wilbur K ^d   Vennerstrom, Jonathan L ^c  

^a HERIOT WATT UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1,10,10 TETRAMETHYL 7,8,15,16 TETRAOXADISPIRO[5.2.5.2]HEXADECANE; 1,5,10,14 TETRAMETHYL 7,8,15,16 TETRAOXADISPIRO[5.2.5.2]HEXADECANE; 7,8,15,16 TETRAOXODISPIRO[5.5.5.2]HEXADECANE; ANTIMALARIAL AGENT; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONFORMATION; DRUG SYNTHESIS; ELECTRON TRANSPORT; MOLECULAR MODEL; NONHUMAN; PLASMODIUM FALCIPARUM; STEREOSPECIFICITY; X RAY CRYSTALLOGRAPHY;

ALKANES; ANIMALS; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034704733     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990530+     Document Type: Article

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