The mechanism of 8-Cl-cAMP action

Journal of Experimental and Clinical Cancer Research

Volumn 17, Issue 3, 1998, Pages 269-275

  Juranic Z ^a   Radulovic S ^b   Joksimovic J ^b   Juranic I ^b  

^a INSTITUTE FOR ONCOLOGY AND RADIOLOGY OF SERBIA   (Serbia)

^b NONE

Author keywords

8 Cl cAMP; Dipyridamol; HeLa cells; Human serum; IBMX; PDE

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 8 CHLOROADENOSINE 3',5' PHOSPHATE; ANTINEOPLASTIC AGENT; DIPYRIDAMOLE; ENZYME INHIBITOR; INOSINATE DEHYDROGENASE; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; TIAZOFURIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; HEAT TREATMENT; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LEUKEMIA CELL; MELANOMA CELL; NONHUMAN; PRIORITY JOURNAL; SERUM;

EID: 0032463331     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Krebs E.G.: Protein kinase. Curr. Top. Cell Regul. 5: 99-133, 1972.
2. Gill G.N., Garren L.D.: Role of the receptor in the mechanism of action of adenosine 3′,5′-cyclic monophosphate. Proc. Natl. Acad. Sci. USA 68: 786-790, 1971.
3. Beebe S.J., Corbin J.D.: Cyclic nucleotide-dependent protein kinases. In: Boyer P.D., ed. The Enzymes, Orlando FL: Academic Press, Inc., 1986, Ed. 3, Vol. 17, pp. 43-111.
4. Fossberg T.M., Doskeland S.O., Ueland P.M.: Protein kinase in human renal cell carcinoma and renal cortex. Arch. Biochem. Biophys. 189: 372-381, 1978.
5. Yasui W., Sumiyoshio H., Ochiai A., Yamahara M.S., Tahara E.: Type I and II cyclic adenosine 3′,5′-monophosphate-dependent protein kinase in human gastric mucosa and carcinomas. Cancer Res. 45: 1565-1568, 1985.
6. Bradbury A.W., Carter D.C., Miller W.R., Cho-Chung Y.S. Clair T.: Protein kinase A (PK-A) regulatory subunit expression in colorectal cancer and related mucosa, Br. J. Cancer 69: 38-742, 1994.
7. Eppenberger U., Biedermann K., Handschin J.C., et al.: Cyclic AMP-dependent protein kinase type I and type II and cyclic AMP binding in human mammary tumours. Adv. Cyclic Nucleotide Res. 12: 123-128, 1980.
8. Gordge P.C., Hulme M.J., Clegg R.A., Miller W.R.: Elevation of protein kinase A activity in malignant as compared with normal human breast tissue, British Journal of Cancer 73: 2.4, 10, 1996.
9. Handschin J.C., Handloser K., Takahashi A., Eppeberger U.: Cyclic adenosinee 3′,5′-monophosphate receptor proteins in dysplastic and neoplastic human breast tissue cytosol and their inverse relationship with estrogen receptors. Cancer Res. 43: 2947-2954, 1983.
10. Weber W., Schwoch G., Schroder H., Hilz H.: Analysis of cAMP, dependent protein kinases by immunotitration: multiple forms-multiple functions? Cold Spring Harbor Conf. Cell proliferation 8: 125-140, 1981.
11. Katsaros D., Tortora G., Tagliaferri P., et al.: Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth. FEBS Lett. 223: 97-103, 1987.
12. Cho-Chung Y.S.: Site-Selective 8-Chloro-Cyclic Adenosine 3′,5′-Monophosphate as a Biologic Modulator of Cancer: Restoration of Normal Control Mechanisms. J. Natl. Cancer Inst. 81: 982-989, 1989.
13. Gentleman S., Hemmings B.A., Russell P., Chader G.J.: Abnormal expression of the RI subunit of cAMP-dependent proteinkinase in Y-79 retinoblastoma cells. Exp. Eye Res. 48: 497-507, 1989.
14. Thompson E.W., Reich R., Shima T.B., et al: Differential regulation of growth and invasiveness of MCF-7 breast caner cells by antiestrogens. Cancer Res. 48: 6764-6768, 1988.
15. Yokozaki H., Budillon A., Tortora G., et al.: An Antiense Oligodeoxynucleotide That Depletes RI Subunit of Cyclic AMP-dependent Protein Kinase Induces Growth Inhibition in Human Cancer Cells. Cancer Research 53: 868-872, 1993.
16. Simpson B.J.B., Burns D.J., Langdon S.P., Miller W.R.: Growth inhibition by antisense oligos against the RIα regulatory subunit of protein kinase a in the MCF-7 breast caner cell line. British Journal of Cancer 73(Suppl. 26): 62, 1996.
17. Tortora G., Yokozaki H., Pepe S., Clair T., and Cho-Chung Y.S.: Differentiation of HL-60 leukemia by type I regulatory subinit antisense oligodeoxynucleotice of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 88: 2011-2015, 1991.
18. Hulme M.J., Bartlett J.M.S., MacCallum J., et al.: Changes in R1 alpha mRNA expression in breast cancer patients treated with tamoxifen. British Journal of Cancer 73: 76, 1996.
19. Cho-Chung Y.S., Clair T., Tagliaferri P., et al.: Basic science review: site-selective cyclic AMP analogs as new biological tools in growth control, differentiation and proto-oncogene regulation. Cancer Invest. 7: 161-177, 1989.
20. Cho-Chung Y.S.: Role of Cyclic AMP Receptor Proteins in Growth, Differentiation, and Suppression of Malignancy: New Approaches to Therapy. Cancer Reseach 50: 093-7100, 1990.
21. Ally S., Tortora G., Clair T., Cho-Chung Y.S.: Selective modulation of protein kinase isozymes by site selective 8-Cl-cAMP provides a biological means for control of human colon cancer cell growth. Proc. Natl. Acad. Sci. USA 85: 6319-6322, 1988.
22. Tagliaferri P., Katsaros D., Clair T. et al.: Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues. Cancer Res 48: 1642-50, 1988.
23. Tortora G., Tagliaferi P., Clair T., et al.: Site-selective cAMP analogs at micromolar concentrations induce growth arrest and differentiation of acute promyelocytic, chronic myelocytic, and acute lymphocytic human leukemia cell lines. Blood 71: 230-233, 1988.
24. Langeveld C.H., Jongenelen C.A.M., Heimans J.J., Stoof J.C.: 8-Chloro-cyclic Adenosine Monophosphate, a Novel Cyclic AMP Analog That Inhibits Human Glioma Cell Growth in Concentrations That Do Not Induce Differentiation. Experimental Neurology 117: 196-203, 1992.
25. Tortora G., Ciardiekko F., Ally S., Clair T., Salomon S., Cho-Chung Y.S.: Site-selective 8-chloroadenosine 3′,5′-cyclic monophosphate inhibits transformation and transforming growth factor a production in Ki-ras-transformed rat fibroblasts. FEBS Lett. 242: 363-367, 1989.
26. Langdon S.P., Ritchie A.A., Muir M., Dodds M., Howie A.F., Miller W.R.: Antitumour Activity and Schedule dependency of 8-chloro-cAMP in human tumour xenografts. British Journal of Cancer 73: 8, 1996.
27. Ramage A.D., Langdon S.P., Ritchie A.A., Burns D.J., Miller W.R.: Growth inhibition by 8-chloro cyclic AMP of human HT29 colorectal and ZR-75-1 breast carcinoma xenografts is associated with selective modulation of protein kinase A isoenzymes, Eur. J. Cancer 31A: 969-73, 1995.
28. Mednieks M.I., Yokozaki H., Merlo G.R. et al.: Site-selective 8-Cl-cAMP which causes growth inhibition and differentiation increases DNA (CRE)-binding activity in cancer cells. Cancer Research 254: 83-88, 1990.
29. Van Lockeren Campagne M.M., Diaz F.V., Jastroff B. et al.: 8-Chloroadenosine 3′,5′-monophosphate inhibits the growth of chinese hamster ovary and MOLT-4 cells through its adenosine metabolite. Cancer Res. 51: 1600-5, 1991.
30. Langeveld C.H., Jongenlen C.A.M., Heimans J.J. et al.: Growth inhibition of human glioma cells induced by chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3′,5′-monophosphate. Cancer Res. 52: 3994-9, 1992.
31. Taylor C.W., Yeoman L.C.: Inhibition of colon tumour cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine. Anti-Cancer Drugs 3: 485-91, 1992.
32. Borselino N., Crescimanno M., Leonardi V., et al.: Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug-resistant tumour cell lines. Pharmacol. Res. 30: 81-90, 1994.
33. Cummings J., Langdon S.P., Ritchie A.A., et al.: Pharmacokinetics, metabolism and tumor disposition of 8-chloradenosine 3′,5′-monophosphate in breast cancer patients and xenograft bearing mice, Annals of Oncology 7: 291-296, 1996.
34. Bennett Jr L.L., Chang C-H., Allan P.W., et al.: Metabolism and metabolic effects of halopurine nucleoside in tumour cells in culture. Nucleosides and Nucleotides 4: 107-16, 1985.
35. Lange-Carter C.A., Vuillequez J.J., Malkinson A.M.: 8-Chloroadenosine Mediates 8-Chloro-Cyclic AMP-induced Down-Regulation of Cyclic AMP-dependent Protein Kinase in Normal and Neoplastic Mouse Lung Epithelial Cells by a Cyclic AMP-independent Mechanism. Cancer Research 5: 393-400, 1993.
36. Cummings J., Leonard R.C.F., Miller W.R.: Preclinical pharmaceutical analysis and preliminary clinical pharmacokinetics of the signal transduction pathway modulator, 8-Cl cAMP. Ann Oncol 5: 178, 1994.
37. Saunders M.P., Salisbury A.J., Harris A.L., et al.: Phase I study of the protein kinase A regulator 8-chloro cyclic AMP. Proc Am Assoc Cancer Res 36: 241, 1995.
38. Mosmann T.: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63, 1983.
39. Ohno M., Abe T.: Rapid colorimetric assay for the quantification of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6). J. Immunol. Methods 145: 199-203, 1991.
40. Rohlff C., Safa B., Rahman A., Cho-Chung Y.S., Klecker R.W., Glazer R.I.: Reversal of Resistance to Adriamycin by 8-Chloro-Cyclic AMP in Adriamycin-Resistant HL-60 Leukemia Cells is Associated with Reduction of Type I Cyclic AMP-Dependent Protein Kinase and Cyclic AMP Response Element-Binding Protein DNA-Binding Activities. Molecular Pharmacology 43: 372-379, 1992.
41. 1 /S Transition in Mammary Carcinoma Cells (MCF-7)*, Copyright 1995 by The Endocrine Society, Vol. 136, No. 6.