New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite

Journal of Medicinal Chemistry

Volumn 42, Issue 16, 1999, Pages 3163-3166

  Takaya, Yoshiaki ^a   Tasaka, Hidehisa ^a   Chiba, Tomoyuki ^a   Uwai, Koji ^a   Tanitsu, Masa Aki ^a   Kim, Hye Sook ^b   Wataya, Yusuke ^b   Miura, Masatomo ^c   Takeshita, Mitsuhiro ^c   Oshima, Yoshiteru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [HYDROXYL 4,4 DIMETHYL 2 OXO 3 QUINOLIZIDYL] 4 QUINAZOLINE; ANTIMALARIAL AGENT; ARTEMISIN; CHLOROQUINE; FEBRIFUGINE; FEBRIFUGINE DERIVATIVE; ISOFEBRIFUGINE; QUINOLIZIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG ISOLATION; DRUG METABOLISM; DRUG STRUCTURE; INTRAPERITONEAL DRUG ADMINISTRATION; MALARIA FALCIPARUM; MALE; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PLANT ROOT; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; DRUGS, CHINESE HERBAL; MALARIA; MALE; MICE; MICE, INBRED ICR; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERIDINES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; QUINAZOLINES; QUINAZOLINONES; QUINOLIZINES;

EID: 0033549898     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990131e     Document Type: Article

References (10)

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