Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli

FEBS Letters

Volumn 397, Issue 2-3, 1996, Pages 210-214

  Blake, Jennifer A R ^a   Pritchard, Mike ^a   Ding, Shaohong ^a   Smith, Graeme C M ^a,b   Burchell, Brian ^a   Wolf, C Roland ^a   Friedberg, Thomas ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Bioreactors; Drug metabolism; E. coli; Heterologous expression; Human; Recombinant cytochrome P450

Indexed keywords

CYTOCHROME P450 REDUCTASE; ERYTHROMYCIN; NIFEDIPINE; TESTOSTERONE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; DRUG METABOLISM; ESCHERICHIA COLI; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

BASE SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; HYDROXYLATION; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; NADH, NADPH OXIDOREDUCTASES; NADPH-FERRIHEMOPROTEIN REDUCTASE; NIFEDIPINE; OXIDATION-REDUCTION; PLASMIDS; RECOMBINANT PROTEINS; TESTOSTERONE;

ESCHERICHIA COLI;

EID: 0030592712     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(96)01196-9     Document Type: Article

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