-
1
-
-
0025139357
-
Inhibition of monoamine oxidases A and by simple isoquinoline alkaloids; racemic and optimally active 1,2,3,4-tetrahydro-3,4-dihydro-, and fully aromatic isoquinolines
-
Bembenek, M. E., Abell, C. W., Chrisey, L. A., Rozwadoeska, M. D., Gesner, W. and Brossi, A. (1990) Inhibition of monoamine oxidases A and by simple isoquinoline alkaloids; racemic and optimally active 1,2,3,4-tetrahydro-3,4-dihydro-, and fully aromatic isoquinolines. J. Med. Chem., 33: 147-152.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 147-152
-
-
Bembenek, M.E.1
Abell, C.W.2
Chrisey, L.A.3
Rozwadoeska, M.D.4
Gesner, W.5
Brossi, A.6
-
2
-
-
0021276089
-
Metabolism of the neurotoxic amine, MPTP by brain monoamine oxidase
-
Chiba , K., Trevor, A. J., and Castagnoli, N. (1984) Metabolism of the neurotoxic amine, MPTP by brain monoamine oxidase. Biochem. Biophys. Res. Commun., 120: 574-578.
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.120
, pp. 574-578
-
-
Chiba, K.1
Trevor, A.J.2
Castagnoli, N.3
-
3
-
-
0023922163
-
Oxidative decarboxylation of salsolinol-1-carboxylic acid to 1,2-dehydrosalsolinol: Evidence for exclusive catalysis by particular factors in rat kidney
-
Collins, M. A. and Cheng B. Y. (1988) Oxidative decarboxylation of salsolinol-1-carboxylic acid to 1,2-dehydrosalsolinol: Evidence for exclusive catalysis by particular factors in rat kidney. Arch. Biochem. Biophys., 263: 86-96.
-
(1988)
Arch. Biochem. Biophys.
, vol.263
, pp. 86-96
-
-
Collins, M.A.1
Cheng, B.Y.2
-
4
-
-
0029099568
-
Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatography
-
Deng, Y., Maruyama, W., Dostert, P., Takahashi, T., M. Kawai and Naoi, M. (1995) Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatography. J. Chromatogr. B., 670: 47-54.
-
(1995)
J. Chromatogr. B
, vol.670
, pp. 47-54
-
-
Deng, Y.1
Maruyama, W.2
Dostert, P.3
Takahashi, T.4
Kawai, M.5
Naoi, M.6
-
5
-
-
0023690768
-
Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases
-
Dostert, P., Strolin Benedetti, M. and Dordain, G. (1988) Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases. J. Neural Transm., 74: 61-74.
-
(1988)
J. Neural Transm.
, vol.74
, pp. 61-74
-
-
Dostert, P.1
Strolin Benedetti, M.2
Dordain, G.3
-
6
-
-
0021224694
-
Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine by monoamine oxidase inhibitor
-
Heikkila, R. E., Manzino, L., Cabbat, F. S. and Duvoisin, R. C. (1984) Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine by monoamine oxidase inhibitor. Nature 311: 467-469.
-
(1984)
Nature
, vol.311
, pp. 467-469
-
-
Heikkila, R.E.1
Manzino, L.2
Cabbat, F.S.3
Duvoisin, R.C.4
-
7
-
-
0023263919
-
Biochemical pathophysiology of Parkinson's disease
-
Homykiewicz, O. and Kish, S. (1986) Biochemical pathophysiology of Parkinson's disease. Adv. Neurol., 45: 19-32.
-
(1986)
Adv. Neurol.
, vol.45
, pp. 19-32
-
-
Homykiewicz, O.1
Kish, S.2
-
8
-
-
0026753805
-
N-Methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains; in vivo microdialysis
-
Maruyama, W., Nakahara, D., Ota, M., Takahashi, T., Takahashi, T., Nagatsu, T. and Naoi, M. (1992) N-Methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains; in vivo microdialysis. J. Neurochem., 59: 395-400.
-
(1992)
J. Neurochem.
, vol.59
, pp. 395-400
-
-
Maruyama, W.1
Nakahara, D.2
Ota, M.3
Takahashi, T.4
Takahashi, T.5
Nagatsu, T.6
Naoi, M.7
-
9
-
-
0027391546
-
Selective release of serotonin by endogenous alkaloids, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, (R)- and (S)salsolinol, in the rat striatum; in vivo microdialysis study
-
Maruyama, W., Nakahara, D. Dostert, P., Hashiguchi, H. Ohta, S., Hirobe, M., Takahashi, A., Nagatsu, T. and Naoi, M. (1993) Selective release of serotonin by endogenous alkaloids, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, (R)- and (S)salsolinol, in the rat striatum; in vivo microdialysis study. Neurosci. Lett., 149: 115-118.
-
(1993)
Neurosci. Lett.
, vol.149
, pp. 115-118
-
-
Maruyama, W.1
Nakahara, D.2
Dostert, P.3
Hashiguchi, H.4
Ohta, S.5
Hirobe, M.6
Takahashi, A.7
Nagatsu, T.8
Naoi, M.9
-
10
-
-
0028341108
-
Inhibition of tyrosine hydroxylase by a dopamine neurotoxin, 1-methyl-4-phenylpyridinium ion: Depletion of allostery to the biopterin cofactor
-
Maruyama, W. and Naoi, M. (1994) Inhibition of tyrosine hydroxylase by a dopamine neurotoxin, 1-methyl-4-phenylpyridinium ion: Depletion of allostery to the biopterin cofactor. Life Sci., 55: 207-212.
-
(1994)
Life Sci.
, vol.55
, pp. 207-212
-
-
Maruyama, W.1
Naoi, M.2
-
11
-
-
0002151546
-
Dopamine-derived isoquinolines as dopaminergic neurotoxins and oxidative stress
-
J. Hanin, M. Yoshida and A. Fisher (Eds.), Plenum, New York and London
-
Maruyama, W., Nakahara, D., Dostert, P., Takahashi, T. and Naoi, M. (1995a) Dopamine-derived isoquinolines as dopaminergic neurotoxins and oxidative stress. In: Alzheimer's and Parkinson's Diseases; Recent Advances. J. Hanin, M. Yoshida and A. Fisher (Eds.), Plenum, New York and London, pp. 575-581.
-
(1995)
Alzheimer's and Parkinson's Diseases; Recent Advances
, pp. 575-581
-
-
Maruyama, W.1
Nakahara, D.2
Dostert, P.3
Takahashi, T.4
Naoi, M.5
-
12
-
-
0028988538
-
Dopamine-derived 1-methyl-6,7-dihydroxyisoquinolines as hydroxyl radical promoters and scavengers in the rat brain: In vivo and in vitro studies
-
Maruyama W., Dostert, P. and Naoi, M. (1995b) Dopamine-derived 1-methyl-6,7-dihydroxyisoquinolines as hydroxyl radical promoters and scavengers in the rat brain: In vivo and in vitro studies. J Neurochem., 64: 2635-2643.
-
(1995)
J Neurochem.
, vol.64
, pp. 2635-2643
-
-
Maruyama, W.1
Dostert, P.2
Naoi, M.3
-
13
-
-
0029019124
-
N-Methyl(R)salsolinol produces hydroxyl radicals; Involvement to neurotoxicity
-
Maruyama, W., P. Dostert, P., Matsubara, K. and Naoi, M. (1995c) N-Methyl(R)salsolinol produces hydroxyl radicals; Involvement to neurotoxicity. Free Rad. Biol. Med., 19: 67-75.
-
(1995)
Free Rad. Biol. Med.
, vol.19
, pp. 67-75
-
-
Maruyama, W.1
Dostert, P.2
Matsubara, K.3
Naoi, M.4
-
14
-
-
0027252719
-
Potential bioactivated neurotoxins, N-methylated β-carbolinium tons, are present in human brain
-
Matsubara, K., Collins, M. A., Akane, A., Ikebuchi, J., Neafsey, E. J., Kagawa, M. and Shiono, H. (1993) Potential bioactivated neurotoxins, N-methylated β-carbolinium tons, are present in human brain. Brain Res., 610: 90-96.
-
(1993)
Brain Res.
, vol.610
, pp. 90-96
-
-
Matsubara, K.1
Collins, M.A.2
Akane, A.3
Ikebuchi, J.4
Neafsey, E.J.5
Kagawa, M.6
Shiono, H.7
-
15
-
-
0024359987
-
An N-methyltransferase in human brain catalyzes N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion
-
Naoi, M., Matsuura, S., Takahashi, T. and Nagatsu, T. (1989) An N-methyltransferase in human brain catalyzes N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion. Biochem. Biophys. Res. Commun., 161: 1213-1219.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.161
, pp. 1213-1219
-
-
Naoi, M.1
Matsuura, S.2
Takahashi, T.3
Nagatsu, T.4
-
16
-
-
0027354025
-
N-Methylated tetrahydroisoquinolines as dopaminergic neurotoxins
-
Naoi, M., Dostert, P., Yoshida, M. and Nagatsu T. (1993a) N-Methylated tetrahydroisoquinolines as dopaminergic neurotoxins. Adv. Neurol., 60: 212-217.
-
(1993)
Adv. Neurol.
, vol.60
, pp. 212-217
-
-
Naoi, M.1
Dostert, P.2
Yoshida, M.3
Nagatsu, T.4
-
17
-
-
13144259588
-
Multi-electrode detection system for determination of neurotransmitters
-
S. H. Parvez, M. Naoi, T. Nagatsu and S. Parvez (Eds.), Elsevier, Amsterdam
-
Naoi, M., Maruyama, W., Acworth, I. N., Nakahara, D. and Parvez, H. (1993b) Multi-electrode detection system for determination of neurotransmitters. In: Methods in Neurotransmitter and Neuropeptide Research, Part 1. S. H. Parvez, M. Naoi, T. Nagatsu and S. Parvez (Eds.), Elsevier, Amsterdam, pp. 1-39.
-
(1993)
Methods in Neurotransmitter and Neuropeptide Research, Part 1
, pp. 1-39
-
-
Naoi, M.1
Maruyama, W.2
Acworth, I.N.3
Nakahara, D.4
Parvez, H.5
-
18
-
-
0028267697
-
Binding of 1,2(N)-dimethyl-6,7-dihydroxy-isoquinolinium ion to melanin: Effects of ferrous and ferric ion on the binding
-
Naoi, M., Maruyama, W. and Dostert, P. (1994a) Binding of 1,2(N)-dimethyl-6,7-dihydroxy-isoquinolinium ion to melanin: effects of ferrous and ferric ion on the binding. Neurosci. Lett., 171: 9-12.
-
(1994)
Neurosci. Lett.
, vol.171
, pp. 9-12
-
-
Naoi, M.1
Maruyama, W.2
Dostert, P.3
-
19
-
-
0028182781
-
Novel toxins and Parkinson's disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin
-
Naoi, M., Maruyama, W., Niwa, T. and Nagatsu, T. (1994b) Novel toxins and Parkinson's disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin. J. Neural Transm. [Suppl.], 41: 197-205.
-
(1994)
J. Neural Transm. [Suppl.]
, vol.41
, pp. 197-205
-
-
Naoi, M.1
Maruyama, W.2
Niwa, T.3
Nagatsu, T.4
-
20
-
-
0042520270
-
Metabolic bioactivation of endogenous isoquinolines as dopaminergic neurotoxins to elicit Parkinson's disease
-
I. Hanin, M. Yoshida and A. Fisher (eds.), Plenum Publishing, New York and London
-
Naoi, M., Maruyama, W., Dostert, P., Nakahara, D., Takahashi, T. and Nagatsu, T. (1995a) Metabolic bioactivation of endogenous isoquinolines as dopaminergic neurotoxins to elicit Parkinson's disease. In: Alzheimer's and Parkinson's Diseases: Recent Advances, I. Hanin, M. Yoshida and A. Fisher (eds.), Plenum Publishing, New York and London, pp. 553-559.
-
(1995)
Alzheimer's and Parkinson's Diseases: Recent Advances
, pp. 553-559
-
-
Naoi, M.1
Maruyama, W.2
Dostert, P.3
Nakahara, D.4
Takahashi, T.5
Nagatsu, T.6
-
21
-
-
0029124292
-
Enzymatic oxidation of the dopaminergic neurotoxin, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, into 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion
-
Naoi, M., Maruyama, W., Zhang, J. P., Takahashi, T., Deng, Y. and Dostert, P. (1995b) Enzymatic oxidation of the dopaminergic neurotoxin, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, into 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion. Life Sci., 11: 1061-1066.
-
(1995)
Life Sci.
, vol.11
, pp. 1061-1066
-
-
Naoi, M.1
Maruyama, W.2
Zhang, J.P.3
Takahashi, T.4
Deng, Y.5
Dostert, P.6
-
22
-
-
0029594138
-
Dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines; oxidation and neurotoxicity
-
Naoi, M., Maruyama, W. and Dosiert, P. (1995c) Dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines; oxidation and neurotoxicity. Progress Brain Res., 106:227-239.
-
(1995)
Progress Brain Res.
, vol.106
, pp. 227-239
-
-
Naoi, M.1
Maruyama, W.2
Dosiert, P.3
-
23
-
-
0030060483
-
Dopamine-derived endogenous 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: Biochemical, pathological and behavioral studies
-
in press
-
Naoi, M., Maniyama, W., Dostert P., Hashizume, Y., Nakahara, D., Takahashi, T. and Ota, M. (1996) Dopamine-derived endogenous 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies. Brain Res., in press.
-
(1996)
Brain Res.
-
-
Naoi, M.1
Maniyama, W.2
Dostert, P.3
Hashizume, Y.4
Nakahara, D.5
Takahashi, T.6
Ota, M.7
-
24
-
-
0025740995
-
Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains
-
Niwa, T., Takeda, N., Yoshizumi, H., Tatematsu, A. Yoshida, M., Dostert, P., Naoi, M. and Nagatsu, T. (1991) Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains. Biochem. Biophys. Res. Commun., 177: 603-609.
-
(1991)
Biochem. Biophys. Res. Commun.
, vol.177
, pp. 603-609
-
-
Niwa, T.1
Takeda, N.2
Yoshizumi, H.3
Tatematsu, A.4
Yoshida, M.5
Dostert, P.6
Naoi, M.7
Nagatsu, T.8
-
26
-
-
0024557734
-
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
-
Riederer, P., Sofic, E., Rausch, W.-D., Schmidt, B., Reynolds, G. P., Jellinger, K. and Youdim, M. B. H. (1989) Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J. Neurochem., 52: 515-520.
-
(1989)
J. Neurochem.
, vol.52
, pp. 515-520
-
-
Riederer, P.1
Sofic, E.2
Rausch, W.-D.3
Schmidt, B.4
Reynolds, G.P.5
Jellinger, K.6
Youdim, M.B.H.7
-
27
-
-
0028109999
-
Determination of total dopamine, R - and S-salsolinol in human plasma by cyclodextrin bonded-phase liquid chromatography with electrochemical detection
-
Sällström Baum, S. and Rommelspracher, H. (1994) Determination of total dopamine, R - and S-salsolinol in human plasma by cyclodextrin bonded-phase liquid chromatography with electrochemical detection. J. Chromatogr. B., 660: 235-241.
-
(1994)
J. Chromatogr. B
, vol.660
, pp. 235-241
-
-
Sällström Baum, S.1
Rommelspracher, H.2
-
28
-
-
0015926907
-
Tetrahydroisoquinoline alkaloids; in vivo metabolites of L-DOPA in man
-
Sandler, M., Carter, S. B., Hunter, K. R. and Stem, G. M. (1973) Tetrahydroisoquinoline alkaloids; in vivo metabolites of L-DOPA in man. Nature, 241: 439-443.
-
(1973)
Nature
, vol.241
, pp. 439-443
-
-
Sandler, M.1
Carter, S.B.2
Hunter, K.R.3
Stem, G.M.4
-
29
-
-
0023224837
-
Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
Singer, T. P., Castagnoli Jr., J. N. Ramsay, R. R. and Trevor, A. J. (1987) Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J. Neurochem., 49: 1-8.
-
(1987)
J. Neurochem.
, vol.49
, pp. 1-8
-
-
Singer, T.P.1
Castagnoli Jr., J.N.2
Ramsay, R.R.3
Trevor, A.J.4
-
30
-
-
0020487344
-
Brain salsolinol levels in alcoholism
-
Sjöquist, B., Eriksson, A. and Winblad, B. (1982a) Brain salsolinol levels in alcoholism. Lancet, i: 675-676.
-
(1982)
Lancet
, vol.1
, pp. 675-676
-
-
Sjöquist, B.1
Eriksson, A.2
Winblad, B.3
-
31
-
-
0020024217
-
Salsolinol and catecholamines in human brain and their relation to alcoholism
-
Sjöquist, B., Eriksson, A. and Winblad, B. (1982b) Salsolinol and catecholamines in human brain and their relation to alcoholism. Prog. Clin. Biol. Res., 90: 56-67.
-
(1982)
Prog. Clin. Biol. Res.
, vol.90
, pp. 56-67
-
-
Sjöquist, B.1
Eriksson, A.2
Winblad, B.3
-
32
-
-
0024314553
-
Ratio of the R and S enantiomers of salsolinol in food and human urine
-
Strolin Benedetti, M., Bellotti, V., Poanezola, E., Carminati, P. and Dostert, P. (1989) Ratio of the R and S enantiomers of salsolinol in food and human urine. J. Neural Transm., 77: 47-53.
-
(1989)
J. Neural Transm.
, vol.77
, pp. 47-53
-
-
Strolin Benedetti, M.1
Bellotti, V.2
Poanezola, E.3
Carminati, P.4
Dostert, P.5
-
33
-
-
0028576861
-
Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system
-
Takahashi, T., Y. Deng, Maruyama, W., Dostert, P., Kawai, M. and Naoi, M. (1994). Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system. J. Neural Transm. [GenSect], 98: 107-118.
-
(1994)
J. Neural Transm. [GenSect]
, vol.98
, pp. 107-118
-
-
Takahashi, T.1
Deng, Y.2
Maruyama, W.3
Dostert, P.4
Kawai, M.5
Naoi, M.6
-
34
-
-
0015382059
-
Alkaloids in mammalian tissue U. Synthesis of (+) and (-) substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolanes
-
Teitel, S., O'Brien, J. and Brossi, A. (1972) Alkaloids in mammalian tissue U. Synthesis of (+) and (-) substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolanes. J. Med. Chem., 15: 845-846.
-
(1972)
J. Med. Chem.
, vol.15
, pp. 845-846
-
-
Teitel, S.1
O'Brien, J.2
Brossi, A.3
-
35
-
-
0027504297
-
Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
-
Tipton, K. F. and Singer T. P. (1993). Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem., 61: 1191-1206.
-
(1993)
J. Neurochem.
, vol.61
, pp. 1191-1206
-
-
Tipton, K.F.1
Singer, T.P.2
|