Circulating human B cells that express surrogate light chains and edited receptors

Nature Immunology

Volumn 1, Issue 3, 2000, Pages 207-213

  Meffre, Eric ^a,b   Davis, Eric ^c   Schiff, Claudine ^d   Cunningham Rundles, Charlotte ^e   Ivashkiv, Lionel B ^f   Staudt, Louis M ^c   Young, James W ^g   Nussenzweig, Michel C ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^e MOUNT SINAI MEDICAL CENTER   (United States)

^f HOSPITAL FOR SPECIAL SURGERY   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN J CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MESSENGER RNA; NUCLEAR PROTEIN; RAG 1 PROTEIN; RAG-1 PROTEIN; RAG2 PROTEIN, HUMAN; V(D)J RECOMBINATION ACTIVATING PROTEIN 2;

AGAMMAGLOBULINEMIA; ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; BLOOD; BONE MARROW TRANSPLANTATION; GENE REARRANGEMENT; GENETIC LINKAGE; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RNA EDITING; X CHROMOSOME;

AGAMMAGLOBULINEMIA; AUTOANTIBODIES; B-LYMPHOCYTES; BASE SEQUENCE; BONE MARROW TRANSPLANTATION; DNA-BINDING PROTEINS; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOGLOBULIN J-CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LINKAGE (GENETICS); MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; RNA EDITING; RNA, MESSENGER; X CHROMOSOME;

EID: 0034278588     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/79739     Document Type: Article

References (63)

1. Goodnow, C. C. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc. Natl Acad. Sci. USA 93, 2264-71 (1996).
2. Nemazee, D. Does immunological tolerance explain the waste in the B-lymphocyte immune system? Experiment and theory. Ann. NY Acad. Sci. 764, 397-401 (1995).
3. Radic, M. Z. & Weigert, M. Origins of anti-DNA antibodies and their implications for B-cell tolerance. Ann. NY Acad. Sci. 764, 384-96 (1995).
4. + bone marrow B cells in vitro. Immunity 6, 429-436 (1997).
5. Melamed, D., Benschop, R. J., Cambier, J. C. & Nemazee, D. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 92, 173-82 (1998).
6. Gay, D., Saunders, T., Camper, S. & Weigert, M. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177, 999-1008 (1993).
7. Radic, M. Z., Erickson, J., Litwin, S. & Weigert, M. B lymphocytes may escape tolerance by revising their antigen receptors. J. Exp. Med. 177, 1165-1173 (1993).
8. Tiegs, S. L., Russell, D. M. & Nemazee, D. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020 (1993).
9. Chen, C., Prak, E. L. & Weigert, M. Editing disease-associated autoantibodies. Immunity 6, 97-105 (1997).
10. Pelanda, R. et al. Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity 7, 765-75 (1997).
11. Xu, H., Li, H., Suri-Payer, E., Hardy, R. R. & Weigert, M. Regulation of anti-DNA B cells in recombination-activating gene-deficient mice. J. Exp. Med. 188, 1247-54 (1998).
12. H joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature 322, 840-2 (1986).
13. Chen, C., Nagy, Z., Prak, E. L. & Weigert, M. Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3, 747-55 (1995).
14. H region of the immunoglobulin heavy chain locus. Eur. J. Immunol. 25, 1888-96 (1995).
15. Prak, E. L. & Weigert, M. Light chain replacement: a new model for antibody gene rearrangement. J. Exp. Med. 182, 541-8 (1995).
16. Retter, M. W. & Nemazee, D. Receptor editing occurs frequently during normal B cell development. J. Exp. Med. 188, 1231-8 (1998).
17. Wilson, P. C. et al. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J. Exp. Med. 191, 1881-94 (2000).
18. k-joints and κ/λ ratios in naive versus memory B-cell subsets to identify traces of receptor editing processes. Curr. Top. Microbiol. Immunol. 246, 141-6 (1999).
19. Giachino, C., Padovan, E. & Lanzavecchia, A. Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes. Eur. J. Immunol. 28, 3506-13 (1998).
20. de Wildt, R. M., Hoet, R. M. A., van Venrooij, W. J., Tomlinson, I. M. & Winter, G. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J. Mol. Biol. 285, 895-901 (1999).
21. Brard, F., Shannon, M., Prak, E. L., Litwin, S. & Weigert, M. Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice. J. Exp. Med. 190, 691-704 (1999).
22. Dorner, T., Foster, S.J., Farner, N.L. & Lipsky, P.E. Immunoglobulin κ chain receptor editing in systemic lupus erythematosus. J. Clin. Invest. 102, 688-94 (1998).
23. Dorner, T., Farner, N. L. & Lipsky, P. E. Ig λ and heavy chain gene usage in early untreated systemic lupus erythematosus suggests intensive B cell stimulation. J. Immunol. 163, 1027-36 (1999).
24. Meffre, E. et al. Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells. J. Exp. Med. 188, 765-72 (1998).
25. Wang, Y. H., Nomura, J., Faye-Petersen, O. M. & Cooper, M. D. Surrogate light chain production during B cell differentiation: differential intracellular versus cell surface expression. J. Immunol. 161, 1132-9 (1998).
26. +mu) proB complex: cell surface expression and biochemical structure of a putative transducing receptor. Blood 93, 4336-46 (1999).
27. Uckun, F. M. Regulation of human B-cell ontogeny. Blood 76, 1908-23 (1990).
28. Pascual, V. et al. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180, 329-339 (1994).
29. + germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts. Immunity 4, 603-13 (1996).
30. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188, 1679-89 (1998).
31. Yu, W. et al. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 400, 682-7 (1999).
32. Monroe, R. et al. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity 11, 201-212 (1999).
33. Tangye, S. G., Liu, Y. J., Aversa, G., Phillips, J. H. & de Vries, J. E. Identification of functional human splenic memory B cells by expression of CD148 and CD27. J. Exp. Med. 188, 1691-703 (1998).
34. Conley, M. E. B cells in patients with X-linked agammaglobulinemia. J. Immunol. 134, 3070-4 (1985).
35. Lassoued, K. et al. Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell 73, 73-86 (1993).
36. Guelpa-Fonlupt, V., Tonnelle, C., Blaise, D., Fougereau, M. & Fumoux, F. Discrete early pro-B and pre-B stages in normal human bone marrow as defined by surface pseudo-light chain expression. Eur. J. Immunol. 24, 257-64 (1994).
37. Ghia, P. et al. Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain loci. J. Exp. Med. 184, 2217-2229 (1996).
38. H gene families display remarkably little polymorphism. EMBO J. 8, 3741-8 (1989).
39. Yamada, M. et al. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J. Exp. Med. 173, 395-407 (1991).
40. + B cells. J. Clin. Invest. 99, 2488-501 (1997).
41. Corbett, S. J., Tomlinson, I. M., Sonnhammer, E. L. L., Buck, D. & Winter, G. Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J. Mol. Biol. 270, 587-97 (1997).
42. Meek, K. D., Hasemann, C. A. & Capra, J. D. Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversity. J. Exp. Med. 170, 39-57 (1989).
43. H rearrangements in newborn autoimmune MRL mice. J. Immunol. 162, 1566-72 (1999).
44. Ichiyoshi, Y. & Casali, P. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. J. Exp. Med. 180, 885-95 (1994).
45. Crouzier, R., Martin, T. & Pasquali, J. L. Heavy chain variable region, light chain variable region, and heavy chain CDR3 influences on the mono- and polyreactivity and on the affinity of human monoclonal rheumatoid factors. J. Immunol. 154, 4526-35 (1995).
46. Han, S., Zheng, B., Schatz, D. G., Spanopoulou, E. & Kelsoe, G. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science 274, 2094-7 (1996).
47. Hikida, M. et al. Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B cells. Science 274, 2092-2094 (1996).
48. Han, S. et al. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 278, 301-305 (1997).
49. Hikida, M., Mori, M., Kawabata, T., Takai, T. & Ohmori, H. Characterization of B cells expressing Recombination Activating Genes in germinal centers of immunized mouse lymph nodes. J. Immunol. 158, 2509-2512 (1997).
50. Papavasiliou, F. et al V(D)J Recombination in Mature B cells a New Mechanism for Diversification of Antibody Responses. Science 278, 298-301 (1997).
51. Hertz, M., Kouskoff, V., Nakamura, T. & Nemazee, D. V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signaling. Nature 394, 292-5 (1998).
52. + B cells. J. Clin. Invest. 99, 1614-27 (1997).
53. Schable, K. F. & Zachau, H. G. The variable genes of the human immunoglobulin kappa locus. Biol. Chem. Hoppe Seyler 374, 1001-22 (1993).
54. Victor, K. D. et al. Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes. J. Clin. Invest. 87, 1603-13 (1991).
55. Bridges, S.L. Jr et al. Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals. J. Clin. Invest. 96, 831-41 (1995).
56. Randen, I., Mellbye, O. J., Forre, O. & Natvig, J. B. The identification of germinal centres and follicular dendritic cell networks in rheumatoid synovial tissue. Scand J. Immunol. 41, 481-6 (1995).
57. H repertoire selection and cell signaling at the preB cell stage. J. Immunol. 162, 41-50 (1999).
58. Mian, I. S., Bradwell, A. R. & Olson, A. J. Structure, function and properties of antibody binding sites. J. Mol. Biol. 217, 133-51 (1991).
59. Manheimer-Lory, A. J., Zandman-Goddard, G., Davidson, A., Aranow, C. & Diamond, B. Lupus-specific antibodies reveal an altered pattern of somatic mutation. J. Clin. Invest. 100, 2538-46 (1997).
60. Erikson, J. et al. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349, 331-4 (1991).
61. Goodnow, C. C., Crosbie, J., Jorgensen, H., Brink, R. A. & Basten, A. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342, 385-391 (1989).
62. Paramithiotis, E. & Cooper, M. D. Memory B lymphocytes migrate to bone marrow in humans. Proc. Natl Acad. Sci. USA 94, 208-12 (1997).
63. Meffre, E. et al. A human non-XLA immunodeficiency disease characterized by blockage of B cell development at an early proB cell stage. J. Clin. Invest. 98, 1519-26 (1996).