Clonal expansion is a characteristic feature of the B-cell repertoire of patients with rheumatoid arthritis

Arthritis Research

Volumn 2, Issue 1, 2000, Pages 50-58

  Itoh, K ^a   Patki, V ^a   Furie, R A ^a   Chartash, E K ^a   Jain, R I ^a   Lane, L ^a   Asnis, S E ^a   Chiorazzi, N ^a  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

Author keywords

B lymphocyte repertoire; Complementarity determining region; Immunoglobulin variable region gene; Rheumatoid arthritis; Synovial tissue

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; ASSAY; AUTOIMMUNITY; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BLOOD; COMPLEMENTARITY DETERMINING REGION; DNA FINGERPRINTING; GENE REARRANGEMENT; GENOME; HUMAN; HUMAN TISSUE; HYPOTHESIS; IMMUNOPATHOGENESIS; LYMPHOCYTE CLONE; MEMORY CELL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; TIME;

ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; CLONE CELLS; DNA; DNA FINGERPRINTING; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; POLYMERASE CHAIN REACTION; RNA; SYNOVIAL FLUID; SYNOVIAL MEMBRANE;

EID: 0034351578     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar68     Document Type: Article

References (32)

1. Rheumatoid arthritis. Pathophysiology and implications for therapy
2. Rheumatoid arthritis
3. How important are T cells in chronic rheumatoid synovitis?
4. + subset in normal human subjects
5. + T cells in rheumatoid arthritis
6. + CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity
7. Clonal dominance among T-lymphocyte infiltrates in arthritis
8. Structure of T cell antigen receptor beta chain in synovial fluid cells from patients with rheumatoid arthritis
9. Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis
10. Evidence for the effects of a superantigen in rheumatoid arthritis
11. CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response
12. + T cell population of rheumatoid arthritis patients
13. Evidence for oligoclonal B cell expansion in the peripheral blood of patients with rheumatoid arthritis
14. Immunoglobulin G3 sub-class production by rheumatoid synovial tissue cultures
15. Synthesis of specific IgG idiotypes by rheumatoid synovium
16. The humoral immune response of the rheumatoid synovium
17. IgG and IgM rheumatoid factor synthesis in rheumatoid synovial membrane cell cultures
18. Analysis of immunoglobulin gamma heavy chain expression in synovial tissue of a patient with rheumatoid arthritis
19. Analysis of immunoglobulin gamma heavy chains from rheumatoid arthritis synovium. Evidence of antigen-driven selection
20. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis
21. CDR3 fingerprinting of immunoglobulin kappa light chains expressed in rheumatoid arthritis. Evidence of antigenic selection or dysregulation of gene rearrangement in B cells
22. B-cell activation and development within chronically inflamed synovium in rheumatoid and reactive arthritis
23. Immunoglobulin gene 'fingerprinting': An approach to analysis of B lymphoid clonality in lymphoproliferative disorders
24. Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias
25. Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification
26. Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells
27. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
28. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
29. Sequential appearance of three different anti-fluorescein combining sites in hyperimmunized rabbits: Characterization by circular dichroism and binding studies
30. Molecular events during maturation of the immune response to oxazolone
31. Affinity maturation in the arsonate system: Lack of dominance of high- affinity antibody subpopulations
32. The identification of germinal centres and follicular dendritic cell networks in rheumatoid synovial tissue