Peptide nucleic acids: Versatile tools for gene therapy strategies

Advanced Drug Delivery Reviews

Volumn 44, Issue 2-3, 2000, Pages 81-95

  Dean, David A ^a,b  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antisense; Gene therapy; Gene transfer; Nuclear import; Peptide nucleic acid; PNA; Transcription; Triplex

Indexed keywords

DNA; GENETIC ENGINEERING; MUTAGENESIS; POLYAMIDES; PROTEINS; RNA;

ANTISENSE; GENE THERAPY; NUCLEASE DIGESTION; PEPTIDE NUCLEIC ACID (PNA); PROTEASE DIGESTION;

POLYPEPTIDES;

ANTISENSE OLIGODEOXYNUCLEOTIDE; CELL EXTRACT; DOUBLE STRANDED DNA; LIGAND; NUCLEASE; OLIGONUCLEOTIDE; PEPTIDE NUCLEIC ACID; POLYAMIDE; PROTEINASE; RNA; SINGLE STRANDED DNA;

BINDING AFFINITY; CELL NUCLEUS; CHROMOSOME; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG STABILITY; DRUG STRUCTURE; GENE ACTIVATION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENETIC TRANSCRIPTION AND TRANSLATION; HUMAN; MUTAGENESIS; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SERUM;

EID: 0034670055     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00087-9     Document Type: Article

References (72)

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2. NMIR solution structure of a peptide nucleic acid complexed with RNA
3. DNA-like double helix formed by peptide nucleic acid
4. PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules
5. Evidence for (PNA)2IDNA triplex structure upon binding of PNA to dsDNA by strand displacement
6. Efficient pH-independent sequence-specific DNA binding by pseudoisocytosine-containing bis-PNA
7. Antisense and antigene properties of peptide nucleic acids
8. Piptide nucleic acid (PHA) binding-mediated induction of human [gamma]-globin gene expression
9. Nuclear import of plasmid DNA in digitonin-permeabilized cells requires both cytoplasmic factors and specific DNA sequences
10. Evaluation of pyrimidine PNA binding to ssDNA targets from nonequilibrium melting experiments
11. Gene chemistry: functionally and conformationally intact fluorescent plasmid DNA
12. Stability of peptide nucleic acids in human serum and cellular extracts
13. Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease 51
14. Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism
15. An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers
16. Enzymatic amplification of translation inhibition of rabbit beta-globin mRNA mediated by anti-messenger 27 oligodeoxynucleotides covalently linked to intercalating agents
17. Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity
18. Antisense properties of duplex- and triplex-forming PNAs
19. Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression
20. A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons
21. Invasion of the CAG triplet repeats by a complementary peptide nucleic acid inhibits transcription of the androgen receptor and TATA-binding protein genes and correlates with refolding of an active nucleosome containing a unique AR gene sequence
22. Isolation of active genes containing GAG repeats by DNA strand invasion by a peptide nucleic acid
23. Inhibition of NFkappa B specific transcriptional activation by PNA strand invasion
24. Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA
25. Additive antisense effects of different PNAs on the in vitro translation of the PML/RARalpha gene
26. Synthesis and characterization of a specific peptide nucleic acid that inhibits expression of inducible NO synthase
27. Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA
28. In vitro transcription and translation inhibition by anti-promyelocytic leukemia (PML)/retinoic acid receptor alpha and anti-PML peptide nucleic acid
29. Inhibition of human telomerase activity by peptide nucleic acids
30. Efficient in vitro inhibition of HIV-1 gag reverse transcription by peptide nucleic acid (PNA) at minimal ratios of PNA/RNA
31. Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids
32. Inhibition of a DNA-helicase by peptide nucleic acids
33. Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells
34. Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair
35. Activation of human γ-globin gene expression via triplex-forming oligonucleotide (TFO)-directed mutations in the γ-globin gene 5 flanking region
36. Peptide nucleic acid. DNA strand displacement loops as artificial transcription promoters
37. Phospholipid membrane permeability of peptide nucleic acid
38. Transformed and immortalized cellular uptake of oligodeoxynucleoside phosphorothioates, 3'-alkylamino oligodeoxynucleotides, 2'-O-methyl oligoribonucleotides, oligodeoxynucleoside methylphosphonates, and peptide nucleic acids
39. Vector-mediated delivery of a polyamide ('peptide') nucleic acid analogue through the blood-brain barrier in vivo
40. Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo
41. PNA-dependent gene chemistry: stable coupling of peptides and oligonucleotides to plasmid DNA
42. The retro-inverso form of a homeobox-derived short peptide is rapidly internalised by cultured neurones: a new basis for an efficient intracellular delivery system
43. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent
44. In vivo protein transduction: delivery of a biologically active protein into the mouse
45. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein
46. A truncated HLV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
47. Cell penetration by transportan
48. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo
49. Trophoblast and ovarian cancer antigen LK26. Sensitivity and specificity in immunopathology and molecular identification as a folate-binding protein
50. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer
51. Optimization of folate-conjugated liposomal vectors for folate receptor-mediated gene therapy
52. Import of plasmid DNA into the nucleus is sequence specific
53. Sequence requirements for plasmid nuclear entry
54. Cell-specific nuclear import of plasmid DNA
55. Affinity capture of putative plasmid DNA shuttle proteins from the mammalian cell cytosol
56. Cellular and molecular barriers to gene transfer by a cationic lipid
57. Nuclear targeting of plasmid DNA in human comeal cells
58. High efficiency transformation by direct microinjection of DNA into cultured mammalian cells
59. Nucleocytoplasmic transport: the soluble phase
60. Transport between the cell nucleus and the cytoplasm
61. The nuclear localization sequence of the 5V40 T antigen promotes transgene uptake and expression in zebrafish embryo nuclei
62. Nuclear localization signal of SV40 T antigen directs import of plasmid DNA into sea urchin male pronuclei in vitro
63. Rapid targeting of plasmid DNA to zebrafish embryo nuclei by the nuclear localization signal of SV40 T antigen
64. Nuclear localization signals: a driving force for nuclear transport of plasmid DNA in zebrafish
65. Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells
66. DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA
67. Nuclear protein import using digitonin-permeabilized cells
68. Coupling of nuclear localization signals to plasmid DNA and specific interaction of the conjugates with importin alpha
69. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus
70. A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA
71. Peptide nucleic acid delivery to human mitochondria
72. DNA-protein conjugates can enter mitochondria via the protein import pathway