Reconstitution of T cell-specific transcription directed by composite NFAT/Oct elements

Journal of Immunology

Volumn 165, Issue 10, 2000, Pages 5646-5655

  Bert, A G ^a   Burrows, J ^a   Hawwari, A ^a   Vadas, M A ^a   Cockerill, P N ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TISSUE SPECIFICITY;

EID: 0034670028     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.10.5646     Document Type: Article

References (60)

1. Combinatorial gene regulation by eukaryotic transcription factors
2. Combinatorial transcription factors
3. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
4. NF-ATp: A transcription factor required for the coordinate induction of several cytokine genes
5. Transcription factors of the NFAT family: Regulation and function
6. Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NFAT) complex
7. 2+, calcineurin, and NF-AT
8. Expression of lymphokine genes in T cells
9. The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A sensitive enhancer
10. Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c
11. Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome
12. The enhanceosome and transcriptional synergy
13. Hemopoietic cell growth factors and their receptors
14. Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T cell transcription factor NFAT
15. The human granulocyte-macrophage colony-stimulating factor gene is autonomously regulated in vivo by an inducible tissue-specific enhancer
16. A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNaseI-hypersensitive site
17. Identification of DNaseI hypersensitive sites within nuclei
18. Generation of an improved luciferase reporter gene plasmid that employs a novel mechanism for high copy replication
19. Luciferase reporter gene vectors for analysis of promoters and enhancers
20. Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
21. Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from an enhancer position in non-lymphoid (HeLa) cells
22. NF-AT-driven interleukin-4 transcription potentiated by NIP45
23. Redox regulation of Brn-2/N-Oct-3 POU domain DNA binding activity and proteolytic formation of N-Oct-5 during melanoma cell nuclear extraction
24. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeobox subdomain
25. Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes
26. cDNA cloning of human N-Oct-3, a nervous-system specific POU domain transcription factor binding to the octamer motif
27. In vivo and in vitro expression of octamer binding proteins in human melanoma metastases, brain tissue and fibroblasts
28. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B
29. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins
30. A B cell coactivator of octamer-binding transcription factors
31. Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells
32. The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene expression
33. CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation
34. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)
35. Coactivation by OCA-B: Definition of critical regions and synergism with general factors
36. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription
37. The binding of a Fos/Jun heterodimer can completely disrupt the structure of a nucleosome
38. Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells
39. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation
40. Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor
41. Coordinate and cooperative roles for NF-AT and AP-I in the regulation of the murine IL-4 gene
42. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
43. Multiple closely linked NFAT/octamer and HMGI(Y) binding sites are part of the interleukin-4 promoter
44. Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein
45. The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2
46. Octamer factors exert a dual effect on the IL-2 and IL-4 promoters
47. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: Roles for NF-Y and NF-ATc
48. Transcriptional regulation during B cell development
49. An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity
50. The BOB.1/OBF.1 co-activator is essential for octamer-dependent transcription in B cells
51. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells
52. 1 progression and for proliferation
53. Octamer-binding proteins in diverse hemopoietic cells
54. Combinatorial regulation of transcription II: The immunoglobulin μ heavy chain gene
55. Transcriptional control during T-cell development
56. Transcriptional regulation of T lymphocyte development and function
57. Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3
58. Regulation of GM-CSF gene transcription by core-binding factor
59. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
60. Nuclear factor of activated T cells contributes to the function of the CD28 response region of the granulocyte-macrophage colony-stimulating factor promoter