CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation

Immunity

Volumn 10, Issue 5, 1999, Pages 515-524

  Avots, Andris ^a   Buttmann, Mathias ^a   Chuvpilo, Sergei ^a   Escher, Cornelia ^a   Smola, Ute ^b   Bannister, Andrew J ^c   Rapp, Ulf R ^b   Kouzarides, Tony ^c   Serfling, Edgar ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE; NUCLEAR PROTEIN; ONCOPROTEIN; RAF PROTEIN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; EMBRYO; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION;

EID: 0033137045     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80051-5     Document Type: Article

References (51)

1. Aramburu, J., Garcia-Cozar, F., Raghavan, A., Okamura, H., Rao, A., and Hogan, P.G. (1998). Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol. Cell 1, 627-637.
2. Baniahmad, A., Köhne, A.C., and Renkawitz, R. (1992). A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor. EMBO J. 11, 1015-1023.
3. Bannister, A.J., and Kouzarides, T. (1996). The CBP co-activator is a histone acetyltransferase. Nature 384, 641-643.
4. Bannister, A.J., Oehler, T., Wilhelm, D., Angel, P., and Kouzarides, T. (1995). Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11, 2509-2514.
5. Beals, C.R., Sheridan, C.M., Turck, C.W., Gardner, P., and Crabtree, G.R. (1997). Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275, 1930-1933.
6. Bownell, J.E., Zhou, J.X., Allis, C.D., and Berger, S.L. (1996). Tetrahymena histone acetyltransferase A: A homolog to yeast GCN5 linking histone acetylation to gene activation. Cell 84, 843-851.
7. Boyle, W.J., van der Geer, P., and Hunter, T. (1991). Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201, 110-149.
8. Bryan, R.G., Li, Y., Lai, J.H., Van, M., Rice, N.R., Rich, R.R., and Tan, T.H. (1994). Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Mol. Cell. Biol. 14, 7933-7942.
9. Cantrell, D. (1996). T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14, 259-274.
10. 2-terminal kinase pathway. Science 280, 1945-1949.
11. Chow, C.W., Rincon, M., Cavanagh, J., Dickens, M., and Davis, R.J. (1997). Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 278, 1638-1641.
12. Chuvpilo, S., Zimmer, M., Kerstan, A., Glöckner, J., Avots, A., Escher, C., Fischer, C., Iniashkina, I., Jankevics, E., Berberich-Siebelt, F., et al. (1999). Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells. Immunity 10, 261-269.
13. Eckner, R. (1996). p300 and CBP as transcriptional regulators and targets of oncogenic events. Biol. Chem. 377, 685-688.
14. Eckner, R., Yao, T.-P., Olread, E., and Livingston, D.M. (1996). Interaction and functional collaboration of p300/CBP and bHLH protein in muscle and B-cell differentiation. Genes Dev. 10, 2478-2490.
15. Garcia-Rodriguez, C., and Rao, A. (1998). Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J. Exp. Med. 187, 2031-2036.
16. Genot, E., Cleverley, S., Henning, S., and Cantrell, D. (1996). Multiple p21ras effector pathways regulate nuclear factor of activated T cells. EMBO J. 15, 3923-3933.
17. Gu, W., and Roeder, R.G. (1997). Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606.
18. Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M. (1993). Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135-2148.
19. Hodge, M.R., Ranger, A.M., de la Brousse, F.C., Hoey, T., Grusby, M.J., and Glimcher, L.H. (1996). Hyperproliferation and dysregulation of IL-4 expression in NF-ATp deficient mice. Immunity 4, 397-405.
20. Hoffmeyer, A., Avots, A., Flory, E., Weber, C., Serfling, E., and Rapp, U.R. (1998). The GABP responsive element of the interleukin-2 enhancer is regulated by JNK/SAPK activating pathways in T lymphocytes. J. Biol. Chem. 273, 10112-10119.
21. Imhoff, A., Yang, X.-J., Ogryzko, V.V., Nakatani, Y., Wolffe, M.R., and Ge, H. (1997). Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol. 7, 689-692.
22. Jacinto, E., Werlen, G., and Karin, M. (1998). Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity 8, 31-41.
23. Janknecht, R., and Nordheim, A. (1996a). MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem. Biophys. Res. Commun. 228, 831-837.
24. Janknecht, R., and Nordheim, A. (1996b) Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene 12, 1961-1969.
25. Kortenjann, M., Thomae, O., and Shaw, P.E. (1994). Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2. Mol.Cell. Biol. 14, 4815-4824.
26. Kwok, R.P.S., Lundblad, J.R., Chrivia, J.C., Richards, J.P., Bächinger, H.P., Brennan, R.G., Roberts, S.G.E., Green, M.R., and GoodMan, R.H. (1994). Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370, 223-226.
27. Lee, J.-S., Galvin, K.M., See, R.H., Eckner, R., Livingston, D., Moran, E., and Shi, Y. (1995). Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev. 9, 1188-1198.
28. Marengere, L.E.M., Wakeham, A.C., Bouchard, D., Kong, Y.-Y., OhTeki, T., Shahinian, A., Bachmann, M., Ohashi, P.S., Penninger, J.M., Crabtree, G.R., et al. (1998). The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 8, 115-124.
29. Martinez-Balbas, M.A., Bannister, A.J., Martin, K., Haus-Seuffert, P., Meisterernst, M., and Kouzarides, T. (1998). The acetyltransferase activity of CBP stimulates transcription. EMBO J. 17, 2886-2893.
30. Martinez-Martinez, S., Gomez del Arco, P., Armesilla, A.L., AramBuru, J., Luo, C., Rao, A., and Redondo, J.M. (1997). Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells. Mol. Cell Biol. 17, 6437-6447.
31. Musti, A.M., Treier, M., and Bohmann, D. (1997). Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases. Science 275, 400-402.
32. Nakajima, T., Fukamizu, A., Takahashi, J., Gage, F.H., Fischer, T., Blenis, J., and Montminy, M.R. (1996). The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell 86, 465-474.
33. Northrop, J.P., Ho, S.N., Chen, L., Thomas, D.J., Timmerman, L.A., Nolan, G.P., Admon, A., and Crabtree, G.R. (1994). NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369, 497-502.
34. Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., and Nakatani, Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959.
35. Park, J., Yaseen, N.R., Hogan, P.G., Rao, A., and Sharma, S. (1995). Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells. J. Biol. Chem. 270, 20653-20659.
36. Pfeuffer, I., Klein-Hessling, S., Heinfling, A., Chuvpilo, S., Escher, C., Brabletz, T., Hentsch, B., Schwarzenbach, H., Matthias, P., and Serfling, E. (1994). Octamer factors exert a dual effect on the IL-2 and IL-4 promoters. J. Immunol. 153, 5572-5585.
37. de la Pompa, J.L., Timmerman, L.A., Takimoto, H., Yoshida, H., Elia, A.J., Samper, A., Potter, J., Wakeham, L., Marengere, L., Langille, B.L., et al. (1998). Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 392, 182-186.
38. Ranger, A.M., Grusby, M.J., Hodge, M.R., Gravallese, E.M., de la Brousse, F.C., Hoey, T., Mickanin, C., Baldwin, H.S., and Glimcher, L.H. (1998a). The transcription factor NF-ATc is essential for cardiac valve formation. Nature 392, 186-190.
39. Ranger, A.M., Hodge, M.R., Gravallese, E.M., Oukka, M., Davidson, L., Alt, F.W., de la Brousse, F.C., Hoey, T., Grusby, M.J., and Glimcher, L.H. (1998b). Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 8, 125-134.
40. Rao, A., Luo, C., and Hogan, P.G. (1997). Transcription factors of the NFAT family: Regulation and function. Annu. Rev. Immunol. 15, 707-747.
41. Schmilz, M.L., and Baeuerle, P.A.. (1994). A vector, pHisGal, allowing bacterial production of proteins fused to a hexahistidine-tagged Gal4 DNA-binding domain. Biotechniques 17, 714-717.
42. Schuh, K., Kneitz, B., Heyer, J., Bommhardt, U., Jankevics, E., Siebelt, F., Pfeffer, K., Müller-Hermelink, H.-K., Schimpl, A., and SerfLing, E. (1998). Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice. Eur. J. Immunol. 28, 2456-2466.
43. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. (1994). JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77, 727-736.
44. Torchia, J., Glass, C., and Rosenfeld, M.G. (1998). Co-activators and co-repressors in the integration of transcriptional responses. Curr. Opin. Cell Biol. 10, 373-383.
45. Treisman, R. (1996). Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell Biol. 8, 205-215.
46. Whitehurst, C.E., Owaki, H., Bruder, J.T., Rapp, U.R., and Geppert, T.D. (1995). The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Raf binding in T cells. J. Biol. Chem. 270, 5594-5599.
47. Wisdom, R., Johnson, R.S., and Moore, C. (1999). c-Jun regulates cell cycle progression and apoptosis by different mechanisms. EMBO J. 18, 188-197.
48. Xanthoudakis, S., Viola, J.P.B., Shaw, K.T.Y., Luo, C., Wallace, J.D., Bozza, P.T., Curran, T., and Rao, A. (1996). An enhanced immune response in mice lacking the transcription factor NFAT1. Science 272, 892-895.
49. Yang, S.-H., Whitmarsh, A.J., Davis, R.J., and Sharrocks, A.D. (1998). Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J. 17, 1740-1749.
50. Yao, T.P., Oh, S.P., Fuchs, M., Zhou, N.-D., Ch'ng, L.E., Newsome, D., Bronson, R.T., Li, E., Livingston, D.M., and Eckner, R. (1998). Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 93, 361-372.
51. Zhu, J., Shibasaki, F., Price, R., Guillemot, J.-C., Yano, T., Dötsch, V., Wagner, G., Ferrara, P., and McKeon, F. (1998). Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase 1 and MEKK1. Cell 93, 851-861.