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Pathways from hematopoietic stem cells to thymocytes
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Rodewald, H.R.1
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of special interest. A detailed review on the stem cell progenitors marking T lymphocyte lineage commitment.
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of special interest Shortman K, Wu L. Early T lymphocyte progenitors. Annu Rev Immunol. 14:1996;29-47 A detailed review on the stem cell progenitors marking T lymphocyte lineage commitment.
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Annu Rev Immunol
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Shortman, K.1
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Leiden JM. Transcriptional regulation of T cell receptor genes. Annu Rev Immunol. 11:1993;539-570.
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0031170879
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+ T cells from a common precursor
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of special interest. A review that summarizes the current state of understanding of how T-cell receptor (TCR) gene rearrangement and expression could influence αβ versus γδ cell-fate decisions during T-cell development.
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+ T cells from a common precursor. Semin Immunol. 9:1997;171-179 A review that summarizes the current state of understanding of how T-cell receptor (TCR) gene rearrangement and expression could influence αβ versus γδ cell-fate decisions during T-cell development.
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Semin Immunol
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Kang, J.1
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Kisielow, P.1
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6
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Early αβ T cell development in the thymus of normal and genetically altered mice
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of outstanding interest. An excellent overview that focuses on the events that follow the entry of the T-cell progenitors into the thymus, with particular emphasis on the role of the pre-T-cell receptor complex in mediating β chain selection.
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of outstanding interest Fehling HJ, Von Boehmer H. Early αβ T cell development in the thymus of normal and genetically altered mice. Curr Opin Immunol. 9:1997;263-275 An excellent overview that focuses on the events that follow the entry of the T-cell progenitors into the thymus, with particular emphasis on the role of the pre-T-cell receptor complex in mediating β chain selection.
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Curr Opin Immunol
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Fehling, H.J.1
Von Boehmer, H.2
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0029954710
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Transcriptional control of lymphoid development lessons from gene targeting
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of outstanding interest. A comprehensive overview of gene disruption studies on transcription factors relevant to lymphoid development
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of outstanding interest Clevers HC, Grosschedl R. Transcriptional control of lymphoid development lessons from gene targeting. Immunol Today. 17:1996;336-343 A comprehensive overview of gene disruption studies on transcription factors relevant to lymphoid development.
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Immunol Today
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Clevers, H.C.1
Grosschedl, R.2
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0029876726
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The transcriptional control of hematopoiesis
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of special interest. A description of representative gene disruption analyses on transcription factors, which impair hematopoiesis to various extents.
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of special interest Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis. Blood. 87:1996;4025-4039 A description of representative gene disruption analyses on transcription factors, which impair hematopoiesis to various extents.
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Blood
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Shivdasani, R.A.1
Orkin, S.H.2
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10
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0030993348
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Transcription factors required for lymphoid lineage commitment
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of outstanding interest. Similar to [8], an overview of gene disruption studies on transcription factors relevant to lymphoid development, with special emphasis on factors involved in the process or lymphoid cell commitment.
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of outstanding interest Georgopoulos K. Transcription factors required for lymphoid lineage commitment. Curr Opin Immunol. 9:1997;222-227 Similar to [8], an overview of gene disruption studies on transcription factors relevant to lymphoid development, with special emphasis on factors involved in the process or lymphoid cell commitment.
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Curr Opin Immunol
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Georgopoulos, K.1
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11
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0030044364
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The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse
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Molnár A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG, Jenkins NA, Bruns G, Georgopoulos K. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol. 156:1996;585-592.
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Molnár, A.1
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Scherer, S.5
Copeland, N.G.6
Jenkins, N.A.7
Bruns, G.8
Georgopoulos, K.9
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12
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0028001362
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The Ikaros gene is required for the development of all lymphoid lineages
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Georgopoulos K, Bigby M, Wang J-H, Molnar A, Wu P, Winandy S, Sharpe A. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 79:1994;143-156.
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Wu, P.5
Winandy, S.6
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13
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0028866897
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A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
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Winandy S, Wu P, Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell. 83:1995;289-299.
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Winandy, S.1
Wu, P.2
Georgopoulos, K.3
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14
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0029831978
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Zing finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development
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of special interest. This paper demonstrates that interactions between Ikaros isoforms with an intact DNA-binding domain are required for their functional activity, whereas interactions between isoforms with and without a DNA-binding domain result in a dimeric complex that cannot bind DNA and cannot activate transcription.
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of special interest Sun L, Liu A, Georgopoulos K. Zing finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J. 15:1996;5358-5369 This paper demonstrates that interactions between Ikaros isoforms with an intact DNA-binding domain are required for their functional activity, whereas interactions between isoforms with and without a DNA-binding domain result in a dimeric complex that cannot bind DNA and cannot activate transcription.
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EMBO J
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Sun, L.1
Liu, A.2
Georgopoulos, K.3
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15
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0030498975
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Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation
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of outstanding interest. A study that investigates the consequences of a deletion at the carboxyl terminus of the Ikaros gene (null mutation) on the development of fetal and adult lymphocytes. This study, in comparison to a previously reported results with a dominant-negative mutation [12], indicates that the action of Ikaros is partially redundant with that of other factor(s) during postnatal thymic cell development.
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of outstanding interest Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity. 5:1996;537-549 A study that investigates the consequences of a deletion at the carboxyl terminus of the Ikaros gene (null mutation) on the development of fetal and adult lymphocytes. This study, in comparison to a previously reported results with a dominant-negative mutation [12], indicates that the action of Ikaros is partially redundant with that of other factor(s) during postnatal thymic cell development.
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(1996)
Immunity
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Wang, J.H.1
Nichogiannopoulou, A.2
Wu, L.3
Sun, L.4
Sharpe, A.H.5
Bigby, M.6
Georgopoulos, K.7
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16
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0030972497
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Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
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of outstanding interest. A description of the structural organization, heterodimerization properties and profiles of gene expression of Aiolos, an Ikaros homolog.
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of outstanding interest Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16:1997;2004-2013 A description of the structural organization, heterodimerization properties and profiles of gene expression of Aiolos, an Ikaros homolog.
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EMBO J
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Morgan, B.1
Sun, L.2
Avitahl, N.3
Andrikopoulos, K.4
Ikeda, T.5
Gonzales, E.6
Wu, P.7
Neben, S.8
Georgopoulos, K.9
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17
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0028136726
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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
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Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 265:1994;1573-1577.
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Science
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Scott, E.W.1
Simon, M.C.2
Anastasi, J.3
Singh, H.4
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18
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0242549003
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Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
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of outstanding interest. Description of a second PU.1 knockout mutation (the first was [17]) which yields living neonates. This study reports the effects of the mutation on postnatal hematopoiesis.
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of outstanding interest McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15:1996;5647-5658 Description of a second PU.1 knockout mutation (the first was [17]) which yields living neonates. This study reports the effects of the mutation on postnatal hematopoiesis.
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(1996)
EMBO J
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McKercher, S.R.1
Torbett, B.E.2
Anderson, K.L.3
Henkel, G.W.4
Vestal, D.J.5
Baribault, H.6
Klemsz, M.7
Feeney, A.J.8
Wu, G.E.9
Paige, C.J.10
Maki, R.A.11
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20
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0029087975
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Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis
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Pandolfi PP, Roth ME, Karis A, Leonard MW, Dzierzak E, Grosveld FG, Engel JD, Lindenbaum MH. Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nature Genet. 11:1995;40-44.
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Nature Genet
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Pandolfi, P.P.1
Roth, M.E.2
Karis, A.3
Leonard, M.W.4
Dzierzak, E.5
Grosveld, F.G.6
Engel, J.D.7
Lindenbaum, M.H.8
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21
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0027215522
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RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development
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Chen J, Lansford R, Stewart V, Young F, Alt FW. RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development. Proc Natl Acad Sci USA. 90:1993;4528-4532.
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Chen, J.1
Lansford, R.2
Stewart, V.3
Young, F.4
Alt, F.W.5
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23
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0029788072
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Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus
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Hattori N, Kawamoto H, Fujimoto S, Kuno K, Katsura Y. Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus. J Exp Med. 184:1996;1137-1147.
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J Exp Med
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Hattori, N.1
Kawamoto, H.2
Fujimoto, S.3
Kuno, K.4
Katsura, Y.5
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24
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-
0030810155
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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
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of special interest. This study reports the selective expression of GATA-3 in Th2 lineage cells. In addition, it demonstrates that expression of Th2-cytokine genes is dependent on GATA-3, as tested by inhibition in a Th2 cell clone by antisense GATA-3 or activation in developing Th1 cells by a constitutively expressed GATA-3 transgene.
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of special interest Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 89:1997;587-596 This study reports the selective expression of GATA-3 in Th2 lineage cells. In addition, it demonstrates that expression of Th2-cytokine genes is dependent on GATA-3, as tested by inhibition in a Th2 cell clone by antisense GATA-3 or activation in developing Th1 cells by a constitutively expressed GATA-3 transgene.
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(1997)
Cell
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Zheng, W.1
Flavell, R.A.2
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25
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0030764961
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Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
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of special interest. This study complements [24], focusing on the analysis of GATA-3 dependent IL5 gene expression in Th2 lineage cells.
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of special interest Zhang DH, Cohn L, Ray P, Bottomly K, Ray A. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem. 272:1997;21597-21603 This study complements [24], focusing on the analysis of GATA-3 dependent IL5 gene expression in Th2 lineage cells.
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(1997)
J Biol Chem
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Zhang, D.H.1
Cohn, L.2
Ray, P.3
Bottomly, K.4
Ray, A.5
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26
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0028985161
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An HMG-box-containing T-cell factor required for thymocyte differentiation
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Verbeek S, Izon D, Hofhuis F, Robanus-Maandag E, Te Riele H, van de Wetering M, Oosterwegel M, Wilson A, MacDonald HR, Clevers HC. An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature. 374:1995;70-74.
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Nature
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Verbeek, S.1
Izon, D.2
Hofhuis, F.3
Robanus-Maandag, E.4
Te Riele, H.5
Van De Wetering, M.6
Oosterwegel, M.7
Wilson, A.8
MacDonald, H.R.9
Clevers, H.C.10
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27
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0030025439
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Selectively impaired development of intestinal T cell receptor γδ + cells and liver CD4+ NK1+ T cell receptor αβ + cells in T cell factor-1-deficient mice
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Ohteki T, Wilson A, Verbeek S, MacDonald HR, Clevers HC. Selectively impaired development of intestinal T cell receptor γδ + cells and liver CD4+ NK1+ T cell receptor αβ + cells in T cell factor-1-deficient mice. Eur J Immunol. 26:1996;351-355.
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Ohteki, T.1
Wilson, A.2
Verbeek, S.3
MacDonald, H.R.4
Clevers, H.C.5
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28
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0027945654
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Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
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Van Genderen C, Okamura RM, Farinas I, Quo R, Parslow TG, Bruhn L, Grosschedl R. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 8:1994;2691-2703.
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Van Genderen, C.1
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Farinas, I.3
Quo, R.4
Parslow, T.G.5
Bruhn, L.6
Grosschedl, R.7
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29
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0028880729
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Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene
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Bories JC, Willerford DM, GrÄvin D, Davidson L, Camus A, Martin P, StÄhelin D, Alt FW. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature. 377:1995;635-638.
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Bories, J.C.1
Willerford, D.M.2
Grävin, D.3
Davidson, L.4
Camus, A.5
Martin, P.6
Stähelin, D.7
Alt, F.W.8
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30
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0028864666
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Muthusamy N, Barton K, Leiden JM. Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature. 377:1995;639-642.
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Muthusamy, N.1
Barton, K.2
Leiden, J.M.3
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31
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0030752361
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E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
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Bain G, Engel I, Robanus Maandag EC, te Riele HP, Voland JR, Sharp LL, Chun J, Huey B, Pinkel D, Murre C. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol. 17:1997;4782-4791.
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Bain, G.1
Engel, I.2
Robanus Maandag, E.C.3
Te Riele, H.P.4
Voland, J.R.5
Sharp, L.L.6
Chun, J.7
Huey, B.8
Pinkel, D.9
Murre, C.10
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32
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Impairment of T cell development in δeF1 mutant mice
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Higashi Y, Moribe H, Takagi T, Sekido R, Kawakami K, Kikutani H, Kondoh H. Impairment of T cell development in δEF1 mutant mice. J Exp Med. 185:1997;1467-1479.
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J Exp Med
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Higashi, Y.1
Moribe, H.2
Takagi, T.3
Sekido, R.4
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0030820417
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+ thymocytes
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+ thymocytes. Immunity. 7:1997;243-254.
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(1997)
Immunity
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Penninger, J.M.1
Sirard, C.2
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Chidgey, A.4
Kozieradzki, I.5
Nghiem, M.6
Hakem, A.7
Kimura, T.8
Timms, E.9
Boyd, R.10
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35
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0030925372
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Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB
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Boothby MR, Mora AL, Scherer DC, Brockman JA, Ballard DW. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB. J Exp Med. 185:1997;1897-1907.
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J Exp Med
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Boothby, M.R.1
Mora, A.L.2
Scherer, D.C.3
Brockman, J.A.4
Ballard, D.W.5
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36
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0031159039
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Abnormal T lymphocyte development induced by targeted overexpression of IκBα
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Esslinger CW, Wilson A, Sordat B, Beermann F, Jongeneel CV. Abnormal T lymphocyte development induced by targeted overexpression of IκBα J Immunol. 158:1997;5075-5078.
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J Immunol
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Esslinger, C.W.1
Wilson, A.2
Sordat, B.3
Beermann, F.4
Jongeneel, C.V.5
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37
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0030823769
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LKLF: A transcriptional regulator of single-positive T cell quiescence and survival
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-/- T cells are shown to have a spontaneously activated phenotype and to be highly susceptible to apoptosis.
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-/- T cells are shown to have a spontaneously activated phenotype and to be highly susceptible to apoptosis.
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Science
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Kuo, C.T.1
Veselits, M.L.2
Leiden, J.M.3
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Developmental regulation of VDJ recombination and lymphocyte differentiation
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Willerford DM, Swat W, Alt FW. Developmental regulation of VDJ recombination and lymphocyte differentiation. Curr Opin Genet Dev. 6:1996;603-609.
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Curr Opin Genet Dev
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Willerford, D.M.1
Swat, W.2
Alt, F.W.3
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39
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0030966099
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Recent advances in understanding V(D)J recombination
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of special interest. The most current extensive overview on the process of V(D)J gene recombination. It discusses in depth the molecular aspects of the recombination reaction.
-
of special interest Gellert M. Recent advances in understanding V(D)J recombination. Adv Immunol. 64:1997;39-64 The most current extensive overview on the process of V(D)J gene recombination. It discusses in depth the molecular aspects of the recombination reaction.
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(1997)
Adv Immunol
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Gellert, M.1
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40
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0029983727
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Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
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of special interest. A detailed review on the control of antigen receptor gene rearrangement and of the role of transcriptional regulatory elements in this process.
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of special interest Sleckman BP, Gorman JR, Alt FW. Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements. Annu Rev Immunol. 14:1996;459-481 A detailed review on the control of antigen receptor gene rearrangement and of the role of transcriptional regulatory elements in this process.
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Annu Rev Immunol
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Sleckman, B.P.1
Gorman, J.R.2
Alt, F.W.3
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41
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0029819322
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Gene-targeted deletion and replacement mutations of the T-cell receptor β-chain enhancer: The role of enhancer elements in controlling V(D)J recombinational accessibility
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of outstanding interest. Along with [42], this study provides evidence that the TCR β-chain gene enhancer is required for TCR β-chain gene rearrangement, germline transcription and αβ T-cell development.
-
of outstanding interest Bories JC, Demengeot J, Davidson L, Alt FW. Gene-targeted deletion and replacement mutations of the T-cell receptor β-chain enhancer: the role of enhancer elements in controlling V(D)J recombinational accessibility. Proc Natl Acad Sci USA. 93:1996;7871-7876 Along with [42], this study provides evidence that the TCR β-chain gene enhancer is required for TCR β-chain gene rearrangement, germline transcription and αβ T-cell development.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7871-7876
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Bories, J.C.1
Demengeot, J.2
Davidson, L.3
Alt, F.W.4
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42
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-
0029842562
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Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development
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of outstanding interest. Along with [41], this study provides evidence that the T-cell receptor (TCR) β-chain gene enhancer is required for TCR β-chain gene rearrangement, germline transcription and αβ T-cell development.
-
of outstanding interest Bouvier G, Watrin F, Naspetti M, Verthuy C, Naquel P, Ferrier P. Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development. Proc Natl Acad Sci USA. 93:1996;7877-7881 Along with [41], this study provides evidence that the T-cell receptor (TCR) β-chain gene enhancer is required for TCR β-chain gene rearrangement, germline transcription and αβ T-cell development.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7877-7881
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Bouvier, G.1
Watrin, F.2
Naspetti, M.3
Verthuy, C.4
Naquel, P.5
Ferrier, P.6
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43
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0030663194
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Function of the TCRα enhancer in αβ and γδ T cells
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of outstanding interest. In this report, the authors demonstrate the requirement of the T-cell receptor (TCR) α-chain gene enhancer element for the germline transcription and rearrangement of the TCR-Jα gene cluster. In addition, the authors show that this element is also involved in TCR α-chain gene expression in mature γδ T cells.
-
of outstanding interest Sleckman BP, Bardon CG, Ferrini R, Davidson L, Alt FW. Function of the TCRα enhancer in αβ and γδ T cells. Immunity. 7:1997;505-515 In this report, the authors demonstrate the requirement of the T-cell receptor (TCR) α-chain gene enhancer element for the germline transcription and rearrangement of the TCR-Jα gene cluster. In addition, the authors show that this element is also involved in TCR α-chain gene expression in mature γδ T cells.
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(1997)
Immunity
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, pp. 505-515
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Sleckman, B.P.1
Bardon, C.G.2
Ferrini, R.3
Davidson, L.4
Alt, F.W.5
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44
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0030273709
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Selective defect in rearrangement of the most 5′ TCR-Jα gene segments evidenced by targeted deletion of the TEA (T early α) element: Implications for regulation of DNA accessibility within the TCR-α locus
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of outstanding interest. This study demonstrates that a regulatory element, endowed with germline transcription promoter activity, controls a narrow window of gene segment recombination at the T-cell receptor (TCR) α-chain gene locus.
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of outstanding interest Villey I, Caillol D, Selz F, Ferrier P, De Villartay JP. Selective defect in rearrangement of the most 5′ TCR-Jα gene segments evidenced by targeted deletion of the TEA (T early α) element: implications for regulation of DNA accessibility within the TCR-α locus. Immunity. 5:1996;331-342 This study demonstrates that a regulatory element, endowed with germline transcription promoter activity, controls a narrow window of gene segment recombination at the T-cell receptor (TCR) α-chain gene locus.
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(1996)
Immunity
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Villey, I.1
Caillol, D.2
Selz, F.3
Ferrier, P.4
De Villartay, J.P.5
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45
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0030045374
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Regulation of T cell receptor α gene rearrangement by c-Myb
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of outstanding interest. Along with [46], this report demonstrates that point mutations in binding sites for transcription factors in the TCR δ - chain gene enhancer selectively impair V(D)J gene recombination events within a transgenic recombination substrate.
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of outstanding interest Hernández-Munain C, Lauzurica P, Kranoel MS. Regulation of T cell receptor α gene rearrangement by c-Myb. J Exp Med. 183:1996;289-293 Along with [46], this report demonstrates that point mutations in binding sites for transcription factors in the TCR δ - chain gene enhancer selectively impair V(D)J gene recombination events within a transgenic recombination substrate.
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(1996)
J Exp Med
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Hernández-Munain, C.1
Lauzurica, P.2
Kranoel, M.S.3
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46
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0030984563
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Regulation of T cell receptor δ gene rearrangement by CBF/PEBP2
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of outstanding interest. Along with [45], this report demonstrates that point mutations in binding sites for transcription factors in the TCR δ - chain gene enhancer selectively impair V(D)J gene recombination events within a transgenic recombination substrate.
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of outstanding interest Lauzurica P, Zhong XP, Krangel MS, Roberts JL. Regulation of T cell receptor δ gene rearrangement by CBF/PEBP2. J Exp Med. 185:1997;1193-1201 Along with [45], this report demonstrates that point mutations in binding sites for transcription factors in the TCR δ - chain gene enhancer selectively impair V(D)J gene recombination events within a transgenic recombination substrate.
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(1997)
J Exp Med
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Lauzurica, P.1
Zhong, X.P.2
Krangel, M.S.3
Roberts, J.L.4
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47
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0031026910
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Developmental regulation of VDJ recombination by the core fragment of the T cell receptor α enhancer
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of outstanding interest. A similar analysis as in [45,46], on point mutations in binding sites for transcription factors, applied to transcription factor binding motifs within the TCR α-chain gene enhancer.
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of outstanding interest Roberts JL, Lauzurica P, Krangel MS. Developmental regulation of VDJ recombination by the core fragment of the T cell receptor α enhancer. J Exp Med. 185:1997;131-140 A similar analysis as in [45,46], on point mutations in binding sites for transcription factors, applied to transcription factor binding motifs within the TCR α-chain gene enhancer.
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(1997)
J Exp Med
, vol.185
, pp. 131-140
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Roberts, J.L.1
Lauzurica, P.2
Krangel, M.S.3
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48
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0025821494
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A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
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Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, Pietryga DW, Scott WJ Jr, Potter SS. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell. 65:1991;677-689.
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Mucenski, M.L.1
McLain, K.2
Kier, A.B.3
Swerdlow, S.H.4
Schreiner, C.M.5
Miller, T.A.6
Pietryga, D.W.7
Scott W.J., Jr.8
Potter, S.S.9
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49
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0030061554
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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
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Okuda T, Van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 84:1996;321-330.
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Cell
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Okuda, T.1
Van Deursen, J.2
Hiebert, S.W.3
Grosveld, G.4
Downing, J.R.5
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50
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0029918597
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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
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Wang O, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA. 93:1996;3444-3449.
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Wang, O.1
Stacy, T.2
Binder, M.3
Marin-Padilla, M.4
Sharpe, A.H.5
Speck, N.A.6
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51
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0031283286
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Tcf/Lef factors earn their wings
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of outstanding interest. A review that summarizes recent progress in the understanding of the Wingless/Wnt signal-transducing pathway, focusing on the role of members of the HMG box DNA-binding Tcf and Lef proteins in the expression of Wingless/Wnt target genes.
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of outstanding interest Clevers H, van de Wetering M. Tcf/Lef factors earn their wings. Trends Genet. 13:1997;485-498 A review that summarizes recent progress in the understanding of the Wingless/Wnt signal-transducing pathway, focusing on the role of members of the HMG box DNA-binding Tcf and Lef proteins in the expression of Wingless/Wnt target genes.
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Trends Genet
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Clevers, H.1
Van De Wetering, M.2
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52
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0030853591
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Notch in vertebrates
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of outstanding interest. A comprehensive review of the Notch signaling pathway, with particular emphasis on recent findings that have implicated Notch in both early and late T-cell development.
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of outstanding interest Robey E. Notch in vertebrates. Curr Opin Genet Dev. 7:1997;551-557 A comprehensive review of the Notch signaling pathway, with particular emphasis on recent findings that have implicated Notch in both early and late T-cell development.
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Robey, E.1
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0031883962
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Redundant regulation of T-cell differentiation and TCRα genes expression by the transcription factors LEF-1 and TCF-1
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Okamura RM, Sigvardsson M, Galceran J, Verbeek S, Clevers H, Grosschedl R. Redundant regulation of T-cell differentiation and TCRα genes expression by the transcription factors LEF-1 and TCF-1. Immunity. 8:1998;11-20.
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Immunity
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Okamura, R.M.1
Sigvardsson, M.2
Galceran, J.3
Verbeek, S.4
Clevers, H.5
Grosschedl, R.6
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